| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $528,661 | -19.8% | 117 | -19 | $4,518 | $12,130,101 | 8 | 20th Century Fox International | false | false |
| 2 | - | Percy Jackson & the Olympians: The Lightning Thief | $244,651 | - | 64 | - | $3,822 | $244,651 | 1 | 20th Century Fox International | true | false |
| 3 | 2 | The Wolfman | $203,113 | -42.8% | 65 | +7 | $3,124 | $676,264 | 2 | Universal Pictures International (UPI) | false | false |
| 4 | - | Toy Story 2 2009 Re-release | $188,965 | - | 29 | - | $6,516 | $188,965 | 1 | Walt Disney Pictures | true | false |
| 5 | 3 | Valentine's Day | $161,634 | -52.9% | 67 | +9 | $2,412 | $618,400 | 2 | Warner Bros. | false | false |
| 6 | 6 | Old Dogs | $98,283 | -21.9% | 67 | +2 | $1,466 | $1,319,402 | 5 | Walt Disney Pictures | false | false |
| 7 | - | The Lovely Bones | $94,119 | - | 54 | - | $1,742 | $94,119 | 1 | Paramount Pictures International | true | false |
| 8 | 4 | Sherlock Holmes | $92,037 | -36.7% | 90 | -5 | $1,022 | $2,588,881 | 6 | Warner Bros. | false | false |
| 9 | - | The Girl with the Dragon Tattoo | $89,125 | - | 23 | - | $3,875 | $89,125 | 1 | N/A | true | false |
| 10 | 7 | Invictus | $77,168 | -18.4% | 52 | +5 | $1,484 | $765,675 | 4 | Warner Bros. | false | false |
| 11 | - | Birds of Paradise | $69,145 | - | 41 | - | $1,686 | $69,145 | 1 | Sony Pictures Releasing | true | false |
| 12 | 12 | Alvin and the Chipmunks: The Squeakquel | $48,349 | -31.2% | 87 | -11 | $555 | $1,015,301 | 5 | 20th Century Fox International | false | false |
| 13 | 10 | Tooth Fairy | $47,873 | -37.7% | 54 | +8 | $886 | $407,473 | 3 | 20th Century Fox International | false | false |
| 14 | 9 | The Hurt Locker | $43,879 | -43.8% | 51 | +1 | $860 | $395,945 | 3 | Distribution Company | false | false |
| 15 | 11 | Precious | $41,486 | -45.5% | 26 | +1 | $1,595 | $146,320 | 2 | N/A | false | false |
| 16 | 8 | Law Abiding Citizen | $39,447 | -52.6% | 42 | - | $939 | $151,706 | 2 | Alfa Films | false | false |
| 17 | 14 | It's Complicated | $25,155 | -42.5% | 41 | -10 | $613 | $1,275,202 | 7 | Universal Pictures International (UPI) | false | false |
| 18 | 13 | Up in the Air | $24,603 | -45.6% | 41 | - | $600 | $687,166 | 5 | Paramount Pictures International | false | false |
| 19 | 15 | The Princess and the Frog | $24,204 | -40% | 44 | -23 | $550 | $1,898,911 | 7 | Walt Disney Pictures | false | false |
| 20 | 16 | An Education | $14,021 | -54.5% | 6 | -8 | $2,336 | $154,429 | 3 | Sony Pictures Releasing | false | false |
| 21 | - | The Wedding Song | $13,483 | - | 5 | - | $2,696 | $13,483 | 1 | Primer Plano Film Group | true | false |
| 22 | 19 | Astro Boy | $6,874 | -24.6% | 26 | +10 | $264 | $147,756 | 4 | Alfa Films | false | false |
| 23 | 20 | The Secret in Their Eyes | $5,747 | -23.5% | 15 | -1 | $383 | $9,226,787 | 28 | Distribution Company | false | false |
| 24 | 17 | Daybreakers | $5,454 | -70.3% | 14 | -12 | $389 | $372,979 | 5 | Distribution Company | false | false |
| 25 | 18 | Nine | $4,329 | -55.6% | 5 | -5 | $865 | $255,722 | 4 | Sony Pictures Releasing | false | false |
| 26 | 21 | Nora's Will | $1,958 | -58.3% | 3 | -3 | $652 | $44,656 | 4 | Primer Plano Film Group | false | false |
| 27 | 22 | The Young Victoria | $1,657 | -64.7% | 10 | +1 | $165 | $170,925 | 6 | Distribution Company | false | false |
| 28 | 28 | 2012 | $1,440 | -0.2% | 2 | -2 | $720 | $4,037,716 | 12 | Sony Pictures Releasing | false | false |
| 29 | 23 | Ninja Assassin | $1,132 | -62.5% | 6 | -2 | $188 | $125,876 | 7 | Warner Bros. | false | false |
| 30 | 26 | Zombieland | $1,003 | -43.9% | 3 | - | $334 | $90,947 | 4 | Sony Pictures Releasing | false | false |
| 31 | 35 | Le code a changé | $864 | +91.6% | 3 | +1 | $288 | $135,232 | 8 | Alfa Films | false | false |
| 32 | 29 | Paranormal Activity | $808 | -42% | 3 | - | $269 | $1,270,631 | 11 | Distribution Company | false | false |
| 33 | 25 | The Wind Journeys | $717 | -61.6% | 2 | - | $358 | $3,329 | 2 | Primer Plano Film Group | false | false |
| 34 | 33 | Departures | $482 | -13.5% | 2 | -1 | $241 | $19,661 | 6 | Alfa Films | false | false |
| 35 | 24 | Andres Doesn't Want to Take a Nap | $421 | -80.4% | 3 | -3 | $140 | $10,595 | 3 | Primer Plano Film Group | false | false |
| 36 | 27 | Jellyfish 2010 Re-release | $315 | -81.7% | 2 | -1 | $157 | $24,761 | 5 | N/A | false | false |
| 37 | 36 | Let it Rain | $234 | -12% | 1 | - | $234 | $139,840 | 11 | Alfa Films | false | false |
| 38 | 5 | Toy Story 2009 Re-release | $221 | -99.8% | 1 | -29 | $221 | $620,584 | 3 | Walt Disney Pictures | false | false |
| 39 | - | Spread | $193 | - | 1 | - | $193 | $121,929 | 8 | Impacto Cine | false | false |
| 40 | 30 | The Twilight Saga: New Moon | $135 | -89.4% | 3 | -4 | $45 | $3,302,723 | 14 | Alfa Films | false | false |
| 41 | 37 | Broken Embraces | $135 | -10.6% | 1 | - | $135 | $520,321 | 21 | Universal Pictures International (UPI) | false | false |
| 42 | 38 | Inglourious Basterds | $125 | -11.3% | 1 | - | $125 | $1,224,736 | 25 | Universal Pictures International (UPI) | false | false |
