| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Wolfman | $326,683 | - | 48 | - | $6,805 | $326,683 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | - | Percy Jackson & the Olympians: The Lightning Thief | $245,610 | - | 43 | - | $5,711 | $245,610 | 1 | 20th Century Fox International | true | false |
| 3 | - | Valentine's Day | $162,925 | - | 28 | - | $5,818 | $162,925 | 1 | Warner Bros. | true | false |
| 4 | 2 | Avatar | $152,437 | -17.1% | 64 | - | $2,381 | $4,798,697 | 9 | 20th Century Fox International | false | false |
| 5 | 1 | Old Dogs | $124,557 | -39.1% | 42 | - | $2,965 | $850,096 | 3 | Walt Disney Pictures | false | false |
| 6 | 3 | Invictus | $35,036 | -45.6% | 20 | - | $1,751 | $142,205 | 2 | Warner Bros. | false | false |
| 7 | 8 | I Hate Valentine's Day | $26,835 | -18.1% | 12 | - | $2,236 | $78,481 | 2 | N/A | false | false |
| 8 | 6 | All the Boys Love Mandy Lane | $24,811 | -44.9% | 14 | - | $1,772 | $92,321 | 2 | N/A | false | false |
| 9 | 4 | Tooth Fairy | $23,447 | -59% | 36 | - | $651 | $877,465 | 5 | 20th Century Fox International | false | false |
| 10 | 7 | Astro Boy | $19,146 | -56% | 25 | - | $765 | $194,530 | 3 | N/A | false | false |
| 11 | 5 | Armored | $16,720 | -69% | 26 | - | $643 | $90,896 | 2 | Sony Pictures Releasing | false | false |
| 12 | 18 | Ninja Assassin | $9,625 | +163.7% | 12 | - | $802 | $130,107 | 4 | Warner Bros. | false | false |
| 13 | 9 | El ratón Pérez 2 | $8,221 | -73.1% | 27 | - | $304 | $63,736 | 2 | Walt Disney Pictures | false | false |
| 14 | 10 | Up in the Air | $5,945 | -72.8% | 14 | - | $424 | $204,248 | 4 | Paramount Pictures International | false | false |
| 15 | 11 | The Imaginarium of Doctor Parnassus | $3,794 | -81% | 3 | -13 | $1,264 | $98,696 | 3 | Sony Pictures Releasing | false | false |
| 16 | 12 | Alvin and the Chipmunks: The Squeakquel | $1,704 | -87.4% | 50 | - | $34 | $1,392,055 | 7 | 20th Century Fox International | false | false |
| 17 | 21 | Funny People | $1,272 | -59.2% | 18 | - | $70 | $158,523 | 11 | Universal Pictures International (UPI) | false | false |
| 18 | 15 | Splinter | $1,246 | -83% | 10 | - | $124 | $63,992 | 3 | N/A | false | false |
| 19 | 13 | Sherlock Holmes | $892 | -92.7% | 48 | - | $18 | $798,823 | 6 | Warner Bros. | false | false |
| 20 | 20 | [Rec]² | $489 | -84.9% | 26 | - | $18 | $486,292 | 7 | N/A | false | false |
| 21 | 27 | I've Loved You So Long | $477 | -58.2% | 6 | - | $79 | $41,077 | 8 | N/A | false | false |
| 22 | 23 | Inside | $306 | -89.5% | 15 | - | $20 | $107,615 | 15 | N/A | false | false |
| 23 | - | Elegy | $246 | - | 9 | - | $27 | $46,624 | 24 | N/A | false | false |
| 24 | 22 | Paranormal Activity | $167 | -94.4% | 25 | - | $6 | $695,701 | 8 | N/A | false | false |
| 25 | 16 | The Stepfather | $147 | -97.4% | 1 | -2 | $147 | $112,104 | 5 | Sony Pictures Releasing | false | false |
