| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $1,140,074 | -27.1% | 406 | -25 | $2,808 | $40,161,397 | 8 | 20th Century Fox International | false | false |
| 2 | 2 | Tooth Fairy | $607,600 | -37.6% | 375 | -10 | $1,620 | $6,505,597 | 4 | 20th Century Fox International | false | false |
| 3 | 3 | The Book of Eli | $595,901 | -31.7% | 299 | -1 | $1,992 | $2,113,488 | 2 | Sony Pictures Releasing | false | false |
| 4 | 4 | It's Complicated | $553,147 | -26.8% | 346 | -4 | $1,598 | $1,976,818 | 2 | Universal Pictures International (UPI) | false | false |
| 5 | 7 | Up in the Air | $225,111 | -36% | 228 | -22 | $987 | $1,762,373 | 3 | Paramount Pictures International | false | false |
| 6 | 6 | Invictus | $223,267 | -36.9% | 170 | -31 | $1,313 | $1,520,717 | 3 | Warner Bros. | false | false |
| 7 | 5 | The Fourth Kind | $214,112 | -42.8% | 208 | -16 | $1,029 | $1,668,134 | 3 | Gussi Films | false | false |
| 8 | - | When in Rome | $204,174 | - | 203 | - | $1,005 | $204,612 | 1 | Walt Disney Pictures | true | false |
| 9 | 11 | Law Abiding Citizen | $192,811 | +28.8% | 190 | +61 | $1,014 | $1,909,822 | 5 | N/A | false | false |
| 10 | 15 | Did You Hear About the Morgans? | $172,130 | +79.8% | 146 | +50 | $1,178 | $1,356,347 | 4 | Sony Pictures Releasing | false | false |
| 11 | 8 | Sherlock Holmes | $139,895 | -59.8% | 238 | -129 | $587 | $11,286,109 | 6 | Warner Bros. | false | false |
| 12 | - | Bad Lieutenant: Port of Call New Orleans | $132,749 | - | 102 | - | $1,301 | $133,293 | 1 | Gussi Films | true | false |
| 13 | 9 | Astro Boy | $123,654 | -49.6% | 149 | - | $829 | $509,035 | 2 | N/A | false | false |
| 14 | 16 | Zombieland | $110,184 | +25.5% | 140 | +31 | $787 | $1,122,700 | 5 | Sony Pictures Releasing | false | false |
| 15 | 10 | Regresa | $87,627 | -57.1% | 128 | -102 | $684 | $945,830 | 3 | N/A | false | false |
| 16 | - | Armored | $80,586 | - | 80 | - | $1,007 | $81,470 | 1 | Sony Pictures Releasing | true | false |
| 17 | - | Franklyn | $72,213 | - | 100 | - | $722 | $72,213 | 1 | N/A | true | false |
| 18 | 13 | Paranormal Activity | $66,337 | -51.7% | 108 | -74 | $614 | $5,877,469 | 7 | Gussi Films | false | false |
| 19 | 12 | Alvin and the Chipmunks: The Squeakquel | $61,852 | -57.5% | 146 | -91 | $423 | $10,164,102 | 7 | 20th Century Fox International | false | false |
| 20 | 14 | All About Steve | $53,291 | -45.4% | 88 | -30 | $605 | $935,372 | 6 | 20th Century Fox International | false | false |
| 21 | 26 | Ninja Assassin | $52,821 | +104.2% | 89 | +62 | $593 | $323,178 | 4 | Warner Bros. | false | false |
| 22 | - | Mongol: The Rise of Genghis Khan | $46,367 | - | 35 | - | $1,324 | $46,367 | 1 | N/A | true | false |
| 23 | - | Paintball | $40,016 | - | 80 | - | $500 | $40,016 | 1 | N/A | true | false |
| 24 | 19 | Labor Pains | $30,577 | -41.4% | 68 | -4 | $449 | $633,158 | 5 | N/A | false | false |
| 25 | 28 | Pandorum | $29,742 | +126.1% | 71 | +39 | $418 | $220,036 | 4 | Gussi Films | false | false |
| 26 | 18 | Mutant Chronicles | $28,798 | -45.9% | 67 | -27 | $429 | $372,318 | 5 | Videocine | false | false |
| 27 | 21 | Everybody's Fine | $23,469 | -49.8% | 58 | -24 | $404 | $1,402,191 | 7 | Walt Disney Pictures | false | false |
| 28 | 23 | Departures | $16,793 | -46.6% | 15 | -5 | $1,119 | $71,881 | 2 | N/A | false | false |
| 29 | 17 | AAA, la película: Sin límite en el tiempo | $16,132 | -78.4% | 101 | -125 | $159 | $410,079 | 3 | Videocine | false | false |
| 30 | 25 | A Serious Man | $14,341 | -51.9% | 12 | -3 | $1,195 | $66,029 | 2 | Universal Pictures International (UPI) | false | false |
| 31 | 30 | New York, I Love You | $8,774 | -3.5% | 18 | -2 | $487 | $362,806 | 8 | N/A | false | false |
| 32 | 29 | Julie & Julia | $7,688 | -41.1% | 18 | -10 | $427 | $575,259 | 16 | Sony Pictures Releasing | false | false |
| 33 | 33 | Fame | $7,628 | +74.1% | 35 | +17 | $217 | $242,628 | 4 | N/A | false | false |
| 34 | 20 | Motherhood | $6,022 | -87.6% | 20 | -20 | $301 | $90,813 | 2 | Gussi Films | false | false |
| 35 | 24 | The Stepfather | $5,474 | -82.2% | 26 | -54 | $210 | $583,591 | 9 | Sony Pictures Releasing | false | false |
| 36 | 31 | Nikté | $4,565 | -13.5% | 18 | -4 | $253 | $1,329,775 | 8 | Universal Pictures International (UPI) | false | false |
| 37 | - | Easy Virtue | $2,924 | - | 7 | - | $417 | $70,741 | 10 | Sony Pictures Releasing | false | false |
| 38 | 35 | Opium: Diary of a Madwoman | $2,647 | -25.9% | 1 | -2 | $2,647 | $48,839 | 5 | N/A | false | false |
| 39 | 36 | The Milk of Sorrow | $2,517 | -12.2% | 4 | +2 | $629 | $39,978 | 4 | N/A | false | false |
| 40 | 38 | Lemon Tree | $213 | -73.8% | 1 | - | $213 | $52,284 | 7 | N/A | false | false |
