| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $6,797,283 | -10.8% | 417 | -7 | $16,300 | $112,698,206 | 8 | 20th Century Fox International | false | false |
| 2 | - | The Princess and the Frog | $3,477,572 | - | 460 | - | $7,559 | $3,508,889 | - | Walt Disney Pictures | - | false |
| 3 | - | Astro Boy | $1,710,567 | - | 407 | - | $4,202 | $1,710,567 | 1 | Entertainment One | true | false |
| 4 | - | Invictus | $1,673,776 | - | 275 | - | $6,086 | $1,673,776 | 1 | Warner Bros. | true | false |
| 5 | 4 | Sherlock Holmes | $1,227,744 | -31.8% | 397 | -55 | $3,092 | $38,342,487 | 7 | Warner Bros. | false | false |
| 6 | 3 | Edge of Darkness | $1,203,198 | -34.5% | 412 | -11 | $2,920 | $4,153,590 | 2 | Icon Film Distribution | false | false |
| 7 | - | Youth in Revolt | $1,165,471 | - | 280 | - | $4,162 | $1,165,471 | 1 | Momentum Pictures | true | false |
| 8 | 2 | Alvin and the Chipmunks: The Squeakquel | $1,143,148 | -38.9% | 470 | -19 | $2,432 | $32,644,062 | 7 | 20th Century Fox International | false | false |
| 9 | 5 | It's Complicated | $878,214 | -34% | 412 | -35 | $2,131 | $12,985,772 | 5 | Universal Pictures International (UPI) | false | false |
| 10 | 6 | Up in the Air | $754,821 | -34.5% | 337 | +2 | $2,239 | $8,742,976 | 4 | Paramount Pictures International | false | false |
| 11 | 9 | Precious | $578,551 | +41.5% | 101 | +54 | $5,728 | $1,273,348 | 2 | Icon Film Distribution | false | false |
| 12 | 8 | The Book of Eli | $353,825 | -53.4% | 237 | -115 | $1,492 | $6,294,247 | 4 | Entertainment Film Distributors | false | false |
| 13 | 12 | A Prophet | $198,346 | -37.6% | 67 | -12 | $2,960 | $1,504,451 | 3 | Optimum Releasing | false | false |
| 14 | 10 | Daybreakers | $132,354 | -64.6% | 139 | -103 | $952 | $6,557,387 | 5 | Lionsgate | false | false |
| 15 | 11 | Brothers | $130,275 | -60.3% | 90 | -98 | $1,447 | $1,611,026 | 3 | Lionsgate | false | false |
