| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $177,796 | -4.1% | 8 | +1 | $22,224 | $1,705,093 | 9 | 20th Century Fox International | false | false |
| 2 | - | Valentine's Day | $67,806 | - | 5 | - | $13,561 | $67,806 | 1 | Warner Bros. | true | false |
| 3 | 2 | The Book of Eli | $40,618 | -14.2% | 8 | - | $5,077 | $149,393 | 3 | - | false | false |
| 4 | - | Percy Jackson & the Olympians: The Lightning Thief | $27,911 | - | 8 | - | $3,488 | $27,911 | 1 | 20th Century Fox International | true | false |
| 5 | 3 | Sherlock Holmes | $22,981 | -45.1% | 7 | -1 | $3,283 | $345,120 | 7 | Warner Bros. | false | false |
| 6 | 4 | It's Complicated | $21,519 | -31.1% | 6 | - | $3,586 | $57,029 | 2 | United International Pictures | false | false |
| 7 | - | Up in the Air | $19,944 | - | 5 | - | $3,988 | $19,944 | 1 | United International Pictures | true | false |
| 8 | 7 | Alvin and the Chipmunks: The Squeakquel | $14,415 | -11.1% | 4 | - | $3,603 | $122,872 | 8 | 20th Century Fox International | false | false |
| 9 | 5 | Triangle | $11,429 | -54.1% | 5 | - | $2,285 | $41,143 | 2 | N/A | false | false |
| 10 | 9 | Old Dogs | $10,662 | -20.9% | 4 | - | $2,665 | $96,436 | 6 | Walt Disney Pictures | false | false |
| 11 | 6 | Did You Hear About the Morgans? | $7,760 | -54.5% | 4 | -1 | $1,940 | $49,290 | 3 | Sony Pictures Releasing | false | false |
| 12 | 8 | Nine | $5,865 | -56.7% | 4 | - | $1,466 | $68,368 | 4 | N/A | false | false |
| 13 | 10 | The Princess and the Frog | $5,580 | -29.9% | 2 | - | $2,790 | $62,726 | 7 | Walt Disney Pictures | false | false |
| 14 | 12 | High Lane | $2,400 | -57.8% | 5 | - | $480 | $15,522 | 3 | N/A | false | false |
| 15 | 11 | 2012 | $2,274 | -61.5% | 4 | -2 | $568 | $1,096,494 | 14 | Sony Pictures Releasing | false | false |
| 16 | 13 | The Box | $2,172 | -33.4% | 3 | - | $724 | $29,352 | 5 | N/A | false | false |
| 17 | 15 | Cirque du Freak: The Vampire's Assistant | $2,115 | -7.7% | 2 | - | $1,057 | $39,629 | 10 | United International Pictures | false | false |
| 18 | 14 | The Ugly Duckling and Me! | $276 | -91% | 1 | -1 | $276 | $4,228 | 2 | N/A | false | false |
| 19 | 18 | Couples Retreat | $160 | +3.2% | 1 | - | $160 | $97,993 | 12 | United International Pictures | false | false |
