| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $7,621,815 | -8.2% | 424 | -4 | $17,975 | $101,942,002 | 7 | 20th Century Fox International | false | false |
| 2 | 3 | Alvin and the Chipmunks: The Squeakquel | $1,872,476 | -20.1% | 489 | -3 | $3,829 | $31,259,410 | 6 | 20th Century Fox International | false | false |
| 3 | - | Edge of Darkness | $1,837,551 | - | 423 | - | $4,344 | $1,837,551 | 1 | Icon Film Distribution | true | false |
| 4 | 2 | Sherlock Holmes | $1,800,486 | -31.5% | 452 | -26 | $3,983 | $36,311,662 | 6 | Warner Bros. | false | false |
| 5 | 5 | It's Complicated | $1,330,726 | -27.6% | 447 | +16 | $2,977 | $11,112,658 | 4 | Universal Pictures International (UPI) | false | false |
| 6 | 4 | Up in the Air | $1,152,203 | -40.7% | 335 | +7 | $3,439 | $7,261,473 | 3 | Paramount Pictures International | false | false |
| 7 | 6 | Toy Story 2 2009 Re-release | $1,081,435 | -26.2% | 261 | +21 | $4,143 | $2,870,682 | 2 | Walt Disney Pictures | false | false |
| 8 | 7 | The Book of Eli | $759,792 | -42.9% | 352 | -35 | $2,158 | $5,517,539 | 3 | Entertainment Film Distributors | false | false |
| 9 | - | Precious | $408,768 | - | 47 | - | $8,697 | $408,768 | 1 | Icon Film Distribution | true | false |
| 10 | 8 | Daybreakers | $374,176 | -44.7% | 242 | -76 | $1,546 | $6,211,071 | 4 | Lionsgate | false | false |
| 11 | 9 | Brothers | $328,115 | -44.4% | 188 | -26 | $1,745 | $1,246,643 | 2 | Lionsgate | false | false |
| 12 | 10 | A Prophet | $318,032 | -36.8% | 79 | +4 | $4,025 | $1,079,919 | 2 | Optimum Releasing | false | false |
| 13 | 11 | The Road | $263,999 | -35.9% | 169 | +13 | $1,562 | $3,641,286 | 4 | Icon Film Distribution | false | false |
| 14 | 13 | St Trinian's 2: The Legend of Fritton's Gold | $213,327 | -33% | 279 | -60 | $764 | $10,877,138 | 7 | Entertainment Film Distributors | false | false |
| 15 | - | Did You Hear About the Morgans? | $193,936 | - | 170 | - | $1,140 | $5,567,152 | - | Sony Pictures Releasing | - | false |
| 16 | - | Sex & Drugs & Rock & Roll | $100,801 | - | 88 | - | $1,145 | $1,038,699 | 4 | Entertainment Film Distributors | false | false |
