| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $5,050,393 | -10.6% | 526 | -66 | $9,601 | $81,900,413 | 7 | 20th Century Fox International | false | false |
| 2 | - | Invictus | $3,097,416 | - | 300 | - | $10,324 | $3,097,416 | 1 | Warner Bros. | true | false |
| 3 | 2 | Sherlock Holmes | $1,744,449 | -40.6% | 417 | -27 | $4,183 | $11,462,831 | 3 | Warner Bros. | false | false |
| 4 | - | Couples Retreat | $1,196,396 | - | 252 | - | $4,747 | $1,196,396 | 1 | United International Pictures | true | false |
| 5 | 3 | Up in the Air | $1,171,745 | -36.3% | 231 | -3 | $5,072 | $3,510,434 | 2 | Paramount Pictures International | false | false |
| 6 | 5 | Tooth Fairy | $835,040 | -16.1% | 301 | +1 | $2,774 | $1,967,272 | 2 | 20th Century Fox International | false | false |
| 7 | - | The Fourth Kind | $738,677 | - | 251 | - | $2,942 | $738,677 | 1 | Aurum Films | true | false |
| 8 | 4 | Nine | $717,196 | -45.7% | 321 | +5 | $2,234 | $2,430,718 | 2 | DeAPlaneta | false | false |
| 9 | 7 | Alvin and the Chipmunks: The Squeakquel | $492,962 | -22.8% | 302 | -11 | $1,632 | $13,127,620 | 6 | 20th Century Fox International | false | false |
| 10 | 6 | The Valdemar Legacy | $332,575 | -58% | 246 | -52 | $1,351 | $1,266,198 | 2 | United International Pictures | false | false |
| 11 | 9 | Cell 211 | $305,294 | -23.6% | 191 | +4 | $1,598 | $15,912,739 | 13 | Paramount Pictures International | false | false |
| 12 | - | The Hurt Locker | $248,359 | - | 67 | - | $3,706 | $248,359 | 1 | DeAPlaneta | true | false |
| 13 | 10 | The White Ribbon | $240,724 | -18.1% | 43 | +3 | $5,598 | $1,063,606 | 3 | Golem Distribución | false | false |
| 14 | 8 | Did You Hear About the Morgans? | $219,564 | -63.5% | 242 | -90 | $907 | $4,442,244 | 4 | Sony Pictures Releasing | false | false |
| 15 | - | Chéri | $208,947 | - | 82 | - | $2,548 | $208,947 | 1 | Alta Films | true | false |
| 16 | - | Krabat and the Legend of the Satanic Mill | $160,781 | - | 97 | - | $1,657 | $160,781 | 1 | N/A | true | false |
| 17 | 15 | A Serious Man | $75,298 | -50.8% | 49 | -20 | $1,536 | $1,225,085 | 4 | United International Pictures | false | false |
| 18 | 12 | It's Complicated | $69,342 | -61.5% | 59 | -66 | $1,175 | $6,613,329 | 6 | United International Pictures | false | false |
| 19 | 16 | Planet 51 | $62,993 | -34.4% | 87 | -29 | $724 | $16,584,809 | 10 | DeAPlaneta | false | false |
| 20 | 13 | Solomon Kane | $44,818 | -74.8% | 72 | -115 | $622 | $4,989,228 | 5 | Aurum Films | false | false |
| 21 | 20 | Cloudy with a Chance of Meatballs | $43,914 | -20.8% | 62 | -20 | $708 | $6,949,515 | 9 | Sony Pictures Releasing | false | false |
| 22 | 14 | Bad Lieutenant: Port of Call New Orleans | $35,065 | -79.1% | 72 | -100 | $487 | $1,862,824 | 4 | Aurum Films | false | false |
| 23 | 11 | My Sister's Keeper | $34,130 | -83.8% | 71 | -152 | $480 | $944,452 | 3 | TriPictures | false | false |
| 24 | 18 | The Hedgehog | $32,434 | -45.1% | 24 | -14 | $1,351 | $1,844,059 | 8 | Alta Films | false | false |
| 25 | 19 | Amreeka | $31,356 | -46.6% | 25 | -4 | $1,254 | $230,557 | 3 | N/A | false | false |
| 26 | 21 | The Flight Before Christmas | $30,558 | -33.8% | 70 | -4 | $436 | $1,407,669 | 6 | Filmax | false | false |
| 27 | - | Woman Without Piano | $23,518 | - | 8 | - | $2,939 | $23,518 | 1 | Avalon | true | false |
| 28 | - | Where the Wild Things Are | $17,149 | - | 29 | - | $591 | $1,431,385 | 7 | Warner Bros. | false | false |
| 29 | - | Agora | $15,826 | - | 26 | - | $608 | $30,401,564 | 17 | 20th Century Fox International | false | false |
| 30 | - | Everybody's Fine | $14,939 | - | 33 | - | $452 | $1,427,202 | 5 | Walt Disney Pictures | false | false |
| 31 | - | The Consul of Sodom | $12,918 | - | 23 | - | $561 | $412,438 | 4 | Aurum Films | false | false |
| 32 | - | Capitalism: A Love Story | $12,765 | - | 23 | - | $555 | $260,757 | 4 | Alta Films | false | false |
