| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $860,426 | -12.1% | 148 | +8 | $5,813 | $10,176,576 | 6 | 20th Century Fox International | false | false |
| 2 | - | Toy Story 2009 Re-release | $279,524 | - | 30 | - | $9,317 | $279,524 | 1 | Walt Disney Pictures | true | false |
| 3 | 2 | Sherlock Holmes | $278,761 | -5.5% | 97 | +10 | $2,873 | $2,193,194 | 4 | Warner Bros. | false | false |
| 4 | 3 | Old Dogs | $230,595 | -4.4% | 66 | -2 | $3,493 | $944,438 | 3 | Walt Disney Pictures | false | false |
| 5 | - | The Hurt Locker | $194,366 | - | 48 | - | $4,049 | $194,366 | 1 | Distribution Company | true | false |
| 6 | 4 | Invictus | $188,276 | -17.3% | 47 | +2 | $4,005 | $506,393 | 2 | Warner Bros. | false | false |
| 7 | - | Tooth Fairy | $173,566 | - | 49 | - | $3,542 | $173,566 | 1 | 20th Century Fox International | true | false |
| 8 | 5 | Alvin and the Chipmunks: The Squeakquel | $149,941 | -14.1% | 95 | +1 | $1,578 | $763,520 | 3 | 20th Century Fox International | false | false |
| 9 | 6 | Up in the Air | $112,211 | -16% | 50 | +1 | $2,244 | $570,149 | 3 | Paramount Pictures International | false | false |
| 10 | 7 | The Princess and the Frog | $100,700 | -16% | 101 | -2 | $997 | $1,755,803 | 5 | Walt Disney Pictures | false | false |
| 11 | 9 | It's Complicated | $83,983 | -16.4% | 58 | -5 | $1,447 | $1,154,775 | 5 | Universal Pictures International (UPI) | false | false |
| 12 | - | An Education | $77,520 | - | 15 | - | $5,168 | $77,520 | 1 | Sony Pictures Releasing | true | false |
| 13 | 8 | Nine | $65,352 | -39.8% | 25 | - | $2,614 | $214,007 | 2 | Sony Pictures Releasing | false | false |
| 14 | 10 | Daybreakers | $62,991 | -19.1% | 32 | -1 | $1,968 | $323,619 | 3 | Distribution Company | false | false |
| 15 | 11 | Astro Boy | $35,914 | -27.6% | 29 | - | $1,238 | $114,929 | 2 | Alfa Films | false | false |
| 16 | 12 | Zombieland | $20,416 | -50.3% | 18 | -2 | $1,134 | $80,676 | 2 | Sony Pictures Releasing | false | false |
| 17 | 14 | The Young Victoria | $11,163 | -25.6% | 14 | -5 | $797 | $158,541 | 4 | Distribution Company | false | false |
| 18 | 13 | Nora's Will | $9,537 | -42.9% | 11 | - | $867 | $32,228 | 2 | Primer Plano Film Group | false | false |
| 19 | 21 | The Secret in Their Eyes | $9,081 | +408.7% | 13 | +8 | $698 | $9,203,114 | 26 | Distribution Company | false | false |
| 20 | 16 | 2012 | $7,418 | -20.8% | 11 | -3 | $674 | $4,008,105 | 10 | Sony Pictures Releasing | false | false |
| 21 | 20 | Halloween II | $5,633 | +210.9% | 11 | +5 | $512 | $116,923 | 5 | Distribution Company | false | false |
| 22 | 15 | Ninja Assassin | $4,670 | -56.8% | 9 | -11 | $518 | $118,742 | 5 | Warner Bros. | false | false |
| 23 | 18 | Paranormal Activity | $4,543 | -28.4% | 8 | -5 | $567 | $1,264,299 | 9 | Distribution Company | false | false |
| 24 | 19 | Jellyfish 2010 Re-release | $3,800 | -28% | 4 | -1 | $950 | $20,535 | 3 | N/A | false | false |
| 25 | 17 | Easy Virtue | $3,501 | -47.7% | 8 | -1 | $437 | $94,229 | 4 | Sony Pictures Releasing | false | false |
| 26 | 24 | Departures | $1,055 | -15.1% | 4 | -1 | $263 | $17,902 | 4 | Alfa Films | false | false |
| 27 | 25 | Le code a changé | $1,039 | -11% | 2 | -1 | $519 | $133,882 | 6 | Alfa Films | false | false |
| 28 | 22 | Let the Right One In | $986 | -44.4% | 3 | - | $328 | $170,887 | 10 | Pachamama Cine | false | false |
| 29 | 23 | Spread | $970 | -28% | 1 | -1 | $970 | $120,734 | 6 | Impacto Cine | false | false |
| 30 | 29 | Two Lovers | $580 | +28.9% | 3 | - | $193 | $394,416 | 12 | Distribution Company | false | false |
| 31 | 26 | 500 Days of Summer | $424 | -33.4% | 3 | - | $141 | $358,052 | 12 | 20th Century Fox International | false | false |
| 32 | 30 | Planet 51 | $399 | +13.4% | 1 | -1 | $399 | $715,856 | 11 | CDI Films | false | false |
| 33 | 33 | The Twilight Saga: New Moon | $335 | +44.4% | 2 | - | $167 | $3,300,071 | 12 | Alfa Films | false | false |
| 34 | 28 | Let it Rain | $302 | -37% | 1 | -1 | $302 | $139,339 | 9 | Alfa Films | false | false |
| 35 | 34 | Broken Embraces | $177 | -13.7% | 1 | -1 | $177 | $519,922 | 19 | Universal Pictures International (UPI) | false | false |
| 36 | 35 | Inglourious Basterds | $99 | -47.9% | 1 | - | $99 | $1,224,323 | 23 | Universal Pictures International (UPI) | false | false |
| 37 | 32 | Acne | $91 | -62.1% | 1 | - | $91 | $3,699 | 5 | Primer Plano Film Group | false | false |
