| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $532,163 | -6.4% | 19 | - | $28,008 | $10,596,263 | 6 | 20th Century Fox International | false | false |
| 2 | - | Old Dogs | $119,499 | - | 19 | - | $6,289 | $149,934 | 1 | Walt Disney Pictures | true | false |
| 3 | - | The Imaginarium of Doctor Parnassus | $112,027 | - | 13 | - | $8,617 | $154,220 | 1 | N/A | true | false |
| 4 | - | Alvin and the Chipmunks: The Squeakquel | $82,296 | - | 16 | - | $5,143 | $129,705 | 1 | 20th Century Fox International | true | false |
| 5 | 2 | Sherlock Holmes | $71,168 | -38.9% | 19 | -2 | $3,745 | $2,297,877 | 5 | Warner Bros. | false | false |
| 6 | 4 | Bodyguards and Assassins | $22,564 | -48% | 12 | -5 | $1,880 | $1,087,368 | 5 | N/A | false | false |
| 7 | 5 | Invictus | $22,243 | -47.3% | 17 | +1 | $1,308 | $109,385 | 2 | Warner Bros. | false | false |
| 8 | 3 | The Men Who Stare at Goats | $19,330 | -62.9% | 9 | - | $2,147 | $131,813 | 2 | N/A | false | false |
| 9 | 6 | Hachi: A Dog's Tale | $9,911 | -63.3% | 7 | -7 | $1,415 | $156,250 | 3 | 20th Century Fox International | false | false |
| 10 | - | The Hedgehog | $7,185 | - | 1 | - | $7,185 | $9,237 | 1 | N/A | true | false |
| 11 | 9 | Air Doll | $4,698 | -43.9% | 3 | - | $1,566 | $24,853 | 2 | N/A | false | false |
| 12 | 7 | Broken Embraces | $4,690 | -58.6% | 3 | -2 | $1,563 | $58,795 | 3 | N/A | false | false |
| 13 | - | Professor Layton and the Eternal Diva | $3,486 | - | 8 | - | $435 | $4,174 | 1 | N/A | true | false |
| 14 | - | Whip It | $3,407 | - | 7 | - | $486 | $4,251 | 1 | N/A | true | false |
| 15 | 12 | 20th Century Boys 3: Redemption | $2,107 | -68% | 2 | -4 | $1,053 | $15,176 | 2 | N/A | false | false |
| 16 | 14 | New York, I Love You | $1,661 | -56% | 1 | -1 | $1,661 | $115,285 | 5 | N/A | false | false |
| 17 | 11 | The Box | $1,006 | -84.8% | 2 | -8 | $503 | $58,890 | 3 | N/A | false | false |
| 18 | 8 | Bad Lieutenant: Port of Call New Orleans | $802 | -92% | 1 | -6 | $802 | $76,113 | 3 | N/A | false | false |
| 19 | 10 | Couples Retreat | $284 | -96.5% | 1 | -6 | $284 | $203,223 | 4 | United International Pictures | false | false |
