| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $8,306,499 | -7.6% | 428 | -13 | $19,407 | $92,542,489 | 6 | 20th Century Fox International | false | false |
| 2 | 2 | Sherlock Holmes | $2,629,567 | -20.3% | 478 | -16 | $5,501 | $34,432,897 | 5 | Warner Bros. | false | false |
| 3 | 3 | Alvin and the Chipmunks: The Squeakquel | $2,342,964 | -6.7% | 492 | - | $4,762 | $29,906,916 | 5 | 20th Century Fox International | false | false |
| 4 | 5 | Up in the Air | $1,942,776 | -8% | 328 | +3 | $5,923 | $5,288,403 | 2 | Paramount Pictures International | false | false |
| 5 | 4 | It's Complicated | $1,837,738 | -13.1% | 431 | -8 | $4,263 | $8,696,074 | 3 | Universal Pictures International (UPI) | false | false |
| 6 | - | Toy Story 2 2009 Re-release | $1,464,625 | - | 240 | - | $6,102 | $1,464,625 | 1 | Walt Disney Pictures | true | false |
| 7 | 6 | The Book of Eli | $1,329,963 | -33.6% | 387 | +2 | $3,436 | $4,246,944 | 2 | Entertainment Film Distributors | false | false |
| 8 | 7 | Daybreakers | $676,976 | -48.3% | 318 | -59 | $2,128 | $5,674,171 | 3 | Lionsgate | false | false |
| 9 | - | Brothers | $590,124 | - | 214 | - | $2,757 | $590,124 | 1 | Lionsgate | true | false |
| 10 | - | A Prophet | $503,040 | - | 75 | - | $6,707 | $503,040 | 1 | Optimum Releasing | true | false |
| 11 | 8 | The Road | $411,609 | -46.2% | 156 | -1 | $2,638 | $3,229,177 | 3 | Icon Film Distribution | false | false |
| 12 | - | Did You Hear About the Morgans? | $320,495 | - | 228 | - | $1,405 | $5,380,498 | - | Sony Pictures Releasing | - | false |
| 13 | 10 | St Trinian's 2: The Legend of Fritton's Gold | $318,374 | -30.6% | 339 | -27 | $939 | $10,937,396 | 6 | Entertainment Film Distributors | false | false |
| 14 | - | Ninja Assassin | $301,732 | - | 224 | - | $1,347 | $301,732 | 1 | Warner Bros. | true | false |
| 15 | - | Veer | $239,122 | - | 46 | - | $5,198 | $239,122 | 1 | Eros Worldwide | true | false |
