| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $5,648,045 | -9.6% | 592 | -43 | $9,540 | $73,949,766 | 6 | 20th Century Fox International | false | false |
| 2 | 2 | Sherlock Holmes | $2,934,961 | -44.2% | 444 | +16 | $6,610 | $9,137,034 | 2 | Warner Bros. | false | false |
| 3 | - | Up in the Air | $1,839,961 | - | 234 | - | $7,863 | $1,839,961 | 1 | Paramount Pictures International | true | false |
| 4 | - | Nine | $1,321,598 | - | 316 | - | $4,182 | $1,321,598 | 1 | DeAPlaneta | true | false |
| 5 | - | Tooth Fairy | $995,767 | - | 300 | - | $3,319 | $995,767 | 1 | 20th Century Fox International | true | false |
| 6 | - | The Valdemar Legacy | $792,061 | - | 298 | - | $2,657 | $792,061 | 1 | United International Pictures | true | false |
| 7 | 4 | Alvin and the Chipmunks: The Squeakquel | $638,292 | -26.9% | 313 | -30 | $2,039 | $12,383,884 | 5 | 20th Century Fox International | false | false |
| 8 | 3 | Did You Hear About the Morgans? | $601,054 | -48% | 332 | -14 | $1,810 | $4,112,235 | 3 | Sony Pictures Releasing | false | false |
| 9 | 6 | Cell 211 | $399,799 | -19.8% | 187 | -19 | $2,137 | $15,430,674 | 12 | Paramount Pictures International | false | false |
| 10 | 11 | The White Ribbon | $293,778 | +4.9% | 40 | +1 | $7,344 | $707,626 | 2 | Golem Distribución | false | false |
| 11 | 5 | My Sister's Keeper | $210,375 | -60.7% | 223 | -11 | $943 | $860,518 | 2 | TriPictures | false | false |
| 12 | 9 | It's Complicated | $180,278 | -57.3% | 125 | -123 | $1,442 | $6,465,619 | 5 | United International Pictures | false | false |
| 13 | 7 | Solomon Kane | $177,615 | -60.9% | 187 | -102 | $949 | $4,863,792 | 4 | - | false | false |
| 14 | 8 | Bad Lieutenant: Port of Call New Orleans | $167,651 | -62.8% | 172 | -52 | $974 | $1,774,032 | 3 | - | false | false |
| 15 | 10 | A Serious Man | $152,927 | -51.7% | 69 | -8 | $2,216 | $1,091,089 | 3 | United International Pictures | false | false |
| 16 | 14 | Planet 51 | $96,030 | -39.2% | 116 | -62 | $827 | $16,545,101 | 9 | DeAPlaneta | false | false |
| 17 | 12 | Hierro | $67,748 | -69.8% | 99 | -5 | $684 | $339,912 | 2 | Paramount Pictures International | false | false |
| 18 | 20 | The Hedgehog | $59,040 | -32.6% | 38 | -12 | $1,553 | $1,779,196 | 7 | Alta Films | false | false |
| 19 | 18 | Amreeka | $58,679 | -34.8% | 29 | - | $2,023 | $179,441 | 2 | N/A | false | false |
| 20 | 16 | Cloudy with a Chance of Meatballs | $55,428 | -42.8% | 82 | -33 | $675 | $6,894,751 | 8 | Sony Pictures Releasing | false | false |
| 21 | 21 | The Flight Before Christmas | $46,186 | -39.5% | 74 | -37 | $624 | $1,334,126 | 5 | Filmax | false | false |
| 22 | 22 | A Perfect Getaway | $14,300 | -75.7% | 25 | -5 | $572 | $87,872 | 2 | Sony Pictures Releasing | false | false |
| 23 | - | The Imaginarium of Doctor Parnassus | $4,720 | - | 3 | - | $1,573 | $1,331,594 | 14 | Sony Pictures Releasing | false | false |
