| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Avatar | $54,401,446 | - | 3,285 | - | $16,560 | $504,868,451 | 5 | Twentieth Century Fox | false | false |
| 2 | - | The Book of Eli | $38,437,553 | - | 3,111 | - | $12,355 | $38,437,553 | 1 | Warner Bros. | true | false |
| 3 | - | The Lovely Bones | $19,910,348 | - | 2,563 | - | $7,768 | $20,377,011 | 6 | DreamWorks | false | false |
| 4 | - | Alvin and the Chipmunks: The Squeakquel | $15,305,808 | - | 3,296 | - | $4,643 | $196,397,651 | 4 | Twentieth Century Fox | false | false |
| 5 | - | The Spy Next Door | $12,877,043 | - | 2,924 | - | $4,403 | $12,877,043 | 1 | Lionsgate | true | false |
| 6 | - | Sherlock Holmes | $12,033,507 | - | 3,173 | - | $3,792 | $182,226,907 | 4 | Warner Bros. | false | false |
| 7 | - | It's Complicated | $9,622,810 | - | 2,670 | - | $3,604 | $90,174,635 | 4 | Universal Pictures | false | false |
| 8 | - | Leap Year | $7,071,470 | - | 2,512 | - | $2,815 | $18,772,640 | 2 | Universal Pictures | false | false |
| 9 | - | The Blind Side | $6,972,350 | - | 2,408 | - | $2,895 | $228,181,615 | 9 | Warner Bros. | false | false |
| 10 | - | Up in the Air | $6,530,101 | - | 2,107 | - | $3,099 | $63,903,119 | 7 | Paramount Pictures | false | false |
| 11 | - | Daybreakers | $6,132,472 | - | 2,523 | - | $2,430 | $25,320,873 | 2 | Lionsgate | false | false |
| 12 | - | The Princess and the Frog | $4,004,707 | - | 1,777 | - | $2,253 | $97,534,038 | 8 | Walt Disney Studios Motion Pictures | false | false |
| 13 | - | Youth in Revolt | $3,560,612 | - | 1,873 | - | $1,901 | $12,699,944 | 2 | - | false | false |
| 14 | - | The Imaginarium of Doctor Parnassus | $1,316,438 | - | 599 | - | $2,197 | $5,068,329 | 4 | Sony Pictures Classics | false | false |
| 15 | - | The Young Victoria | $1,153,976 | - | 418 | - | $2,760 | $6,308,737 | 5 | Apparition | false | false |
| 16 | - | The Twilight Saga: New Moon | $1,134,419 | - | 724 | - | $1,566 | $292,434,830 | 9 | Summit Entertainment | false | false |
| 17 | - | A Single Man | $996,546 | - | 219 | - | $4,550 | $3,473,046 | 6 | The Weinstein Company | false | false |
| 18 | - | Invictus | $992,925 | - | 602 | - | $1,649 | $35,161,677 | 6 | Warner Bros. | false | false |
| 19 | - | Crazy Heart | $858,369 | - | 47 | - | $18,263 | $2,285,965 | 5 | - | false | false |
| 20 | - | Nine | $724,241 | - | 422 | - | $1,716 | $18,291,144 | 5 | The Weinstein Company | false | false |
| 21 | - | 2012 | $544,017 | - | 373 | - | $1,458 | $164,767,722 | 10 | Sony Pictures Releasing | false | false |
| 22 | - | Planet 51 | $528,853 | - | 371 | - | $1,425 | $40,230,452 | 9 | Sony Pictures Releasing | false | false |
| 23 | - | Broken Embraces | $496,419 | - | 202 | - | $2,457 | $3,198,729 | 9 | Sony Pictures Classics | false | false |
| 24 | - | Did You Hear About the Morgans? | $463,365 | - | 521 | - | $889 | $29,353,372 | 5 | Sony Pictures Releasing | false | false |
| 25 | - | 3 Idiots | $374,515 | - | 120 | - | $3,120 | $6,102,795 | 4 | Reliance Big Pictures | false | false |
| 26 | - | Precious | $314,016 | - | 228 | - | $1,377 | $44,833,760 | 11 | Lionsgate | false | false |
| 27 | - | Fantastic Mr. Fox | $280,641 | - | 196 | - | $1,431 | $20,005,240 | 10 | Twentieth Century Fox | false | false |
| 28 | - | Old Dogs | $213,770 | - | 196 | - | $1,090 | $48,010,719 | 8 | Walt Disney Studios Motion Pictures | false | false |
| 29 | - | An Education | $175,322 | - | 73 | - | $2,401 | $8,414,860 | 15 | Sony Pictures Classics | false | false |
| 30 | - | Cloudy with a Chance of Meatballs | $173,161 | - | 192 | - | $901 | $124,758,315 | 18 | Sony Pictures Releasing | false | false |
| 31 | - | Brothers | $152,353 | - | 174 | - | $875 | $28,501,651 | 7 | Lionsgate | false | false |
| 32 | - | Ninja Assassin | $151,998 | - | 206 | - | $737 | $37,810,515 | 8 | Warner Bros. | false | false |
| 33 | - | The Road | $150,375 | - | 145 | - | $1,037 | $7,643,625 | 8 | - | false | false |
| 34 | - | The Horse Boy | $147,618 | - | 2 | - | $73,809 | $147,618 | 16 | Zeitgeist Films | false | false |
| 35 | - | Couples Retreat | $146,185 | - | 169 | - | $865 | $108,931,010 | 15 | Universal Pictures | false | false |
| 36 | - | Where the Wild Things Are | $136,007 | - | 185 | - | $735 | $77,013,927 | 14 | Warner Bros. | false | false |
| 37 | - | Chance Pe Dance | $130,160 | - | 68 | - | $1,914 | $130,160 | 1 | UTV Motion Pictures | true | false |
| 38 | - | Under the Sea 3D | $124,965 | - | 28 | - | $4,463 | $19,672,631 | 49 | Warner Bros. | false | false |
| 39 | - | A Christmas Carol | $109,557 | - | 171 | - | $640 | $137,752,895 | 11 | Walt Disney Studios Motion Pictures | false | false |
| 40 | - | The White Ribbon | $103,151 | - | 12 | - | $8,595 | $298,271 | 3 | Sony Pictures Classics | false | false |
| 41 | - | The Last Station | $94,093 | - | 3 | - | $31,364 | $94,093 | 1 | Sony Pictures Classics | true | false |
| 42 | - | The Men Who Stare at Goats | $83,091 | - | 142 | - | $585 | $32,303,929 | 11 | Overture Films | false | false |
| 43 | - | Law Abiding Citizen | $71,597 | - | 125 | - | $572 | $73,228,545 | 14 | Overture Films | false | false |
| 44 | - | The Boondock Saints II: All Saints Day | $36,408 | - | 50 | - | $728 | $10,150,172 | 12 | Apparition | false | false |
| 45 | - | Fish Tank | $32,619 | - | 2 | - | $16,309 | $32,619 | 1 | IFC Films | true | false |
| 46 | - | Bad Lieutenant: Port of Call New Orleans | $31,180 | - | 43 | - | $725 | $1,545,247 | 9 | First Look International | false | false |
| 47 | - | Me and Orson Welles | $30,836 | - | 20 | - | $1,541 | $1,070,524 | 8 | Freestyle Releasing | false | false |
| 48 | - | Sea Monsters: A Prehistoric Adventure | $25,777 | - | 8 | - | $3,222 | $22,776,201 | 120 | National Geographic Entertainment | false | false |
| 49 | - | Astro Boy | $20,230 | - | 54 | - | $374 | $19,548,064 | 13 | Summit Entertainment | false | false |
| 50 | - | The Secrets of Jonathan Sperry | $17,326 | - | 7 | - | $2,475 | $1,187,154 | 18 | Five & Two Pictures | false | false |
| 51 | - | House | $16,108 | - | 1 | - | $16,108 | $16,108 | 1 | Janus Films | true | false |
| 52 | - | The Private Lives of Pippa Lee | $14,166 | - | 11 | - | $1,287 | $282,107 | 8 | Screen Media Films | false | false |
| 53 | - | The Maid | $12,917 | - | 11 | - | $1,174 | $520,203 | 14 | Elephant Eye Films | false | false |
| 54 | - | Coco Before Chanel | $10,144 | - | 18 | - | $563 | $6,058,566 | 17 | Sony Pictures Classics | false | false |
| 55 | - | Red Cliff | $7,922 | - | 11 | - | $720 | $562,668 | 9 | Magnolia Pictures | false | false |
| 56 | - | Killing Kasztner | $7,285 | - | 3 | - | $2,428 | $59,342 | 13 | Sky Island Films | false | false |
| 57 | - | Paranormal Activity | $6,148 | - | 52 | - | $118 | $107,917,283 | 17 | Paramount Pictures | false | false |
| 58 | - | 44 Inch Chest 2010 Re-release | $5,187 | - | 1 | - | $5,187 | $5,187 | 1 | Image Entertainment | true | false |
| 59 | - | Until the Light Takes Us | $5,041 | - | 2 | - | $2,520 | $58,804 | 7 | Variance Films | false | false |
| 60 | - | The Little Traitor | $3,765 | - | 1 | - | $3,765 | $100,696 | 13 | N/A | false | false |
| 61 | - | A Town Called Panic | $3,368 | - | 1 | - | $3,368 | $24,530 | 5 | Zeitgeist Films | false | false |
| 62 | - | The Missing Person | $2,424 | - | 3 | - | $808 | $13,521 | 9 | Strand Releasing | false | false |
| 63 | - | Wonderful World | $1,923 | - | 2 | - | $961 | $8,622 | 2 | Magnolia Pictures | false | false |
| 64 | - | The Yes Men Fix the World | $1,865 | - | 4 | - | $466 | $170,570 | 17 | Shadow Distribution | false | false |
| 65 | - | Mystery Team | $1,726 | - | 1 | - | $1,726 | $55,467 | 21 | Roadside Attractions | false | false |
| 66 | - | Four Seasons Lodge | $1,674 | - | 2 | - | $837 | $47,959 | 10 | First Run | false | false |
| 67 | - | Good Hair | $1,591 | - | 2 | - | $795 | $4,151,039 | 15 | Roadside Attractions | false | false |
| 68 | - | Seraphine | $1,521 | - | 1 | - | $1,521 | $860,807 | 33 | Music Box Films | false | false |
| 69 | - | Cloud 9 | $990 | - | 1 | - | $990 | $88,368 | 23 | Music Box Films | false | false |
| 70 | - | Crude | $861 | - | 2 | - | $430 | $165,452 | 19 | First Run | false | false |
| 71 | - | The Damned United | $811 | - | 6 | - | $135 | $442,740 | 15 | Sony Pictures Classics | false | false |
| 72 | - | The Slammin' Salmon | $660 | - | 1 | - | $660 | $41,023 | 6 | Anchor Bay Films | false | false |
| 73 | - | Bitch Slap | $577 | - | 2 | - | $288 | $17,365 | 2 | Freestyle Releasing | false | false |
| 74 | - | Youssou Ndour: I Bring What I Love | $550 | - | 1 | - | $550 | $165,555 | 32 | Shadow Distribution | false | false |
| 75 | - | $9.99 | $544 | - | 1 | - | $544 | $52,107 | 58 | Regent Releasing | false | false |
| 76 | - | Peter and Vandy | $515 | - | 1 | - | $515 | $11,276 | 15 | Strand Releasing | false | false |
| 77 | - | Le combat dans l'île | $407 | - | 1 | - | $407 | $38,237 | - | The Film Desk | - | false |
| 78 | - | That Evening Sun | $393 | - | 1 | - | $393 | $48,503 | 11 | Freestyle Releasing | false | false |
| 79 | - | Waiting for Armageddon | $369 | - | 1 | - | $369 | $4,583 | 2 | First Run | false | false |
| 80 | - | The September Issue | $270 | - | 2 | - | $135 | $3,818,522 | 21 | Roadside Attractions | false | false |
| 81 | - | The Headless Woman | $236 | - | 1 | - | $236 | $96,191 | 22 | Strand Releasing | false | false |
| 82 | - | Under Our Skin | $175 | - | 1 | - | $175 | $93,557 | 31 | Shadow Distribution | false | false |
| 83 | - | Departures | $156 | - | 1 | - | $156 | $1,493,537 | 34 | Regent Releasing | false | false |
