| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $521,796 | -24.4% | 98 | -1 | $5,324 | $5,117,155 | 6 | 20th Century Fox International | false | false |
| 2 | - | Legion | $363,193 | - | 50 | - | $7,263 | $363,193 | 1 | Sony Pictures Releasing | true | false |
| 3 | - | Tooth Fairy | $185,552 | - | 50 | - | $3,711 | $185,552 | 1 | 20th Century Fox International | true | false |
| 4 | 4 | The Spy Next Door | $167,504 | -45.9% | 60 | - | $2,791 | $552,426 | 2 | Viva International Pictures | false | false |
| 5 | 2 | Sherlock Holmes | $150,148 | -56.9% | 55 | - | $2,729 | $1,077,538 | 3 | Warner Bros. | false | false |
| 6 | 3 | Alvin and the Chipmunks: The Squeakquel | $113,403 | -66% | 50 | - | $2,268 | $1,011,275 | 3 | 20th Century Fox International | false | false |
| 7 | - | Old Dogs | $93,717 | - | 50 | - | $1,874 | $93,717 | 1 | Walt Disney Pictures | true | false |
| 8 | 5 | Daybreakers | $53,575 | -23.7% | 18 | - | $2,976 | $170,667 | 2 | Pioneer Films | false | false |
| 9 | - | The Imaginarium of Doctor Parnassus | $29,853 | - | 17 | - | $1,756 | $29,853 | 1 | Pioneer Films | true | false |
| 10 | 6 | Zombieland | $14,666 | -66.8% | 27 | -22 | $543 | $185,795 | 3 | Sony Pictures Releasing | false | false |
