| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $8,991,441 | +17.6% | 441 | -52 | $20,388 | $80,322,948 | 5 | 20th Century Fox International | false | false |
| 2 | 2 | Sherlock Holmes | $3,299,629 | +1.6% | 494 | +8 | $6,679 | $30,631,419 | 4 | Warner Bros. | false | false |
| 3 | 4 | Alvin and the Chipmunks: The Squeakquel | $2,510,119 | +28.3% | 492 | +3 | $5,101 | $27,432,409 | 4 | 20th Century Fox International | false | false |
| 4 | 5 | It's Complicated | $2,115,796 | +20.2% | 439 | +5 | $4,819 | $5,354,249 | 2 | Universal Pictures International (UPI) | false | false |
| 5 | - | Up in the Air | $2,111,637 | - | 325 | - | $6,497 | $2,111,637 | 1 | Paramount Pictures International | true | false |
| 6 | - | The Book of Eli | $2,004,231 | - | 385 | - | $5,205 | $2,004,231 | 1 | Entertainment Film Distributors | true | false |
| 7 | 3 | Daybreakers | $1,309,195 | -39.3% | 377 | -1 | $3,472 | $4,453,189 | 2 | Lionsgate | false | false |
| 8 | 6 | The Road | $765,661 | -23.8% | 157 | - | $4,876 | $2,456,442 | 2 | Icon Film Distribution | false | false |
| 9 | - | Did You Hear About the Morgans? | $644,389 | - | 339 | - | $1,900 | $4,825,461 | - | Sony Pictures Releasing | - | false |
| 10 | 9 | St Trinian's 2: The Legend of Fritton's Gold | $458,837 | -2.6% | 366 | -24 | $1,253 | $10,648,892 | 5 | Entertainment Film Distributors | false | false |
| 11 | - | All About Steve | $447,508 | - | 189 | - | $2,367 | $447,508 | 20 | 20th Century Fox International | false | false |
| 12 | - | 44 Inch Chest 2010 Re-release | $247,553 | - | 75 | - | $3,300 | $247,553 | 1 | Momentum Pictures | true | false |
| 13 | 8 | Nine | $243,361 | -55.1% | 185 | -184 | $1,315 | $4,573,141 | 8 | Entertainment Film Distributors | false | false |
| 14 | 10 | Sex & Drugs & Rock & Roll | $217,623 | -21.9% | 121 | -10 | $1,798 | $696,203 | 2 | Entertainment Film Distributors | false | false |
| 15 | - | 3 Idiots | $194,322 | - | 49 | - | $3,965 | $2,531,879 | - | - | - | false |
| 16 | 13 | Planet 51 | $147,353 | +16.1% | 203 | -57 | $725 | $7,368,928 | 9 | Entertainment Film Distributors | false | false |
