| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $6,249,331 | -6.8% | 635 | -109 | $9,841 | $66,657,075 | 5 | 20th Century Fox International | false | false |
| 2 | - | Sherlock Holmes | $5,257,980 | - | 428 | - | $12,285 | $5,257,980 | 1 | Warner Bros. | true | false |
| 3 | 2 | Did You Hear About the Morgans? | $1,156,850 | -37.2% | 346 | - | $3,343 | $3,309,692 | 2 | Sony Pictures Releasing | false | false |
| 4 | 3 | Alvin and the Chipmunks: The Squeakquel | $873,406 | -21.5% | 343 | -7 | $2,546 | $11,745,592 | 4 | 20th Century Fox International | false | false |
| 5 | - | My Sister's Keeper | $534,835 | - | 234 | - | $2,285 | $534,835 | 1 | TriPictures | true | false |
| 6 | 7 | Cell 211 | $498,300 | +14.8% | 206 | +18 | $2,418 | $14,959,592 | 11 | Paramount Pictures International | false | false |
| 7 | 4 | Solomon Kane | $453,986 | -47.3% | 289 | -6 | $1,570 | $4,622,437 | 3 | Aurum Films | false | false |
| 8 | 5 | Bad Lieutenant: Port of Call New Orleans | $450,623 | -47.3% | 224 | - | $2,011 | $1,511,012 | 2 | Aurum Films | false | false |
| 9 | 6 | It's Complicated | $422,032 | -31.7% | 248 | -57 | $1,701 | $6,147,328 | 4 | United International Pictures | false | false |
| 10 | 9 | A Serious Man | $316,325 | -24.3% | 77 | +17 | $4,108 | $848,875 | 2 | United International Pictures | false | false |
| 11 | - | The White Ribbon | $279,952 | - | 39 | - | $7,178 | $279,952 | 1 | Golem Distribución | true | false |
| 12 | - | Hierro | $224,456 | - | 104 | - | $2,158 | $224,456 | 1 | Paramount Pictures International | true | false |
| 13 | 8 | Ghosts of Girlfriends Past | $179,684 | -58.4% | 233 | -62 | $771 | $2,622,399 | 3 | TriPictures | false | false |
| 14 | 10 | Planet 51 | $157,827 | -38% | 178 | -73 | $886 | $16,403,531 | 8 | DeAPlaneta | false | false |
| 15 | 12 | Everybody's Fine | $102,735 | -54.4% | 148 | -40 | $694 | $1,337,124 | 3 | Walt Disney Pictures | false | false |
| 16 | 18 | Cloudy with a Chance of Meatballs | $96,829 | -18% | 115 | -44 | $841 | $6,832,475 | 7 | Sony Pictures Releasing | false | false |
| 17 | 13 | The Consul of Sodom | $90,491 | -46.8% | 82 | -8 | $1,103 | $334,859 | 2 | Aurum Films | false | false |
| 18 | - | Amreeka | $90,008 | - | 29 | - | $3,103 | $90,008 | 1 | N/A | true | false |
| 19 | 11 | Zombieland | $89,247 | -61.6% | 134 | -95 | $666 | $3,305,898 | 4 | Sony Pictures Releasing | false | false |
| 20 | 20 | The Hedgehog | $87,619 | -19.7% | 50 | -3 | $1,752 | $1,698,849 | 6 | Alta Films | false | false |
| 21 | 17 | The Flight Before Christmas | $76,390 | -38.5% | 111 | -21 | $688 | $1,278,651 | 4 | Filmax | false | false |
| 22 | - | A Perfect Getaway | $58,888 | - | 30 | - | $1,962 | $58,888 | 1 | Sony Pictures Releasing | true | false |
| 23 | 22 | Old Dogs | $57,309 | -27.3% | 63 | -48 | $909 | $5,742,813 | 7 | Walt Disney Pictures | false | false |
| 24 | 21 | Capitalism: A Love Story | $54,366 | -45.6% | 46 | - | $1,181 | $185,024 | 2 | Alta Films | false | false |
| 25 | 23 | Where the Wild Things Are | $51,668 | -27% | 61 | -21 | $847 | $1,368,315 | 5 | Warner Bros. | false | false |
| 26 | 15 | Spanish Movie | $50,024 | -64.1% | 79 | -85 | $633 | $10,875,184 | 7 | 20th Century Fox International | false | false |
| 27 | 19 | Fame | $39,879 | -65.4% | 76 | -136 | $524 | $2,502,695 | 4 | Filmax | false | false |
| 28 | 14 | Love Happens | $30,451 | -78.7% | 54 | -145 | $563 | $958,449 | 3 | N/A | false | false |
| 29 | 27 | Agora | $28,892 | -0.6% | 26 | +6 | $1,111 | $30,338,802 | 15 | 20th Century Fox International | false | false |
