| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $6,704,235 | -30.5% | 744 | -50 | $9,011 | $57,818,985 | 4 | 20th Century Fox International | false | false |
| 2 | - | Did You Hear About the Morgans? | $1,842,503 | - | 346 | - | $5,325 | $1,848,123 | 1 | Sony Pictures Releasing | true | false |
| 3 | 2 | Alvin and the Chipmunks: The Squeakquel | $1,113,153 | -61% | 350 | -5 | $3,180 | $10,670,960 | 3 | 20th Century Fox International | false | false |
| 4 | 3 | Solomon Kane | $861,561 | -59.8% | 295 | -1 | $2,920 | $3,955,313 | 2 | - | false | false |
| 5 | - | Bad Lieutenant: Port of Call New Orleans | $855,761 | - | 224 | - | $3,820 | $855,761 | 1 | - | true | false |
| 6 | 4 | It's Complicated | $618,077 | -55.5% | 305 | -22 | $2,026 | $5,538,919 | 3 | United International Pictures | false | false |
| 7 | 9 | Cell 211 | $434,058 | -27.8% | 188 | -4 | $2,308 | $14,311,367 | 10 | Paramount Pictures International | false | false |
| 8 | 5 | Ghosts of Girlfriends Past | $431,717 | -67.6% | 295 | -3 | $1,463 | $2,365,297 | 2 | TriPictures | false | false |
| 9 | - | A Serious Man | $418,099 | - | 60 | - | $6,968 | $418,099 | 1 | United International Pictures | true | false |
| 10 | 7 | Planet 51 | $254,505 | -58.1% | 251 | -36 | $1,013 | $16,226,757 | 7 | DeAPlaneta | false | false |
| 11 | 6 | Zombieland | $232,236 | -63.1% | 229 | -21 | $1,014 | $3,176,388 | 3 | Sony Pictures Releasing | false | false |
| 12 | 8 | Everybody's Fine | $225,066 | -62.8% | 188 | -1 | $1,197 | $1,162,186 | 2 | Walt Disney Pictures | false | false |
| 13 | - | The Consul of Sodom | $170,175 | - | 90 | - | $1,890 | $170,175 | 1 | - | true | false |
| 14 | 10 | Love Happens | $143,259 | -69.6% | 199 | +1 | $719 | $894,503 | 2 | N/A | false | false |
| 15 | 13 | Spanish Movie | $139,250 | -65.6% | 164 | -78 | $849 | $10,799,323 | 6 | 20th Century Fox International | false | false |
| 16 | 11 | 9 | $124,879 | -72.3% | 202 | - | $618 | $798,512 | 2 | United International Pictures | false | false |
| 17 | 14 | The Flight Before Christmas | $124,147 | -52.4% | 132 | -2 | $940 | $1,194,695 | 3 | Filmax | false | false |
| 18 | 15 | Cloudy with a Chance of Meatballs | $118,150 | -46.8% | 159 | -80 | $743 | $6,731,009 | 6 | Sony Pictures Releasing | false | false |
| 19 | 12 | Fame | $115,411 | -72.3% | 212 | -57 | $544 | $2,418,230 | 3 | Filmax | false | false |
| 20 | 18 | The Hedgehog | $109,080 | -41.1% | 53 | -10 | $2,058 | $1,570,847 | 5 | Alta Films | false | false |
| 21 | - | Capitalism: A Love Story | $99,866 | - | 46 | - | $2,171 | $99,866 | 1 | Alta Films | true | false |
| 22 | 17 | Old Dogs | $78,806 | -58.4% | 111 | -48 | $709 | $5,674,375 | 6 | Walt Disney Pictures | false | false |
| 23 | 20 | Where the Wild Things Are | $70,779 | -47.1% | 82 | -42 | $863 | $1,301,144 | 4 | Warner Bros. | false | false |
| 24 | 16 | The Greatest | $54,251 | -74.1% | 92 | -1 | $589 | $364,636 | 2 | N/A | false | false |
| 25 | 21 | The Twilight Saga: New Moon | $49,106 | -51.1% | 63 | -62 | $779 | $28,617,897 | 8 | - | false | false |
| 26 | 19 | Ninja Assassin | $32,919 | -78.7% | 91 | -113 | $361 | $1,147,360 | 3 | Warner Bros. | false | false |
| 27 | 24 | Agora | $29,070 | -39.3% | 20 | -2 | $1,453 | $30,299,481 | 14 | 20th Century Fox International | false | false |
| 28 | 22 | 2012 | $25,740 | -70.3% | 34 | -63 | $757 | $22,564,790 | 9 | Sony Pictures Releasing | false | false |
| 29 | 27 | Garbo: The Spy | $24,015 | -23.5% | 5 | -1 | $4,803 | $237,287 | 6 | N/A | false | false |
