| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $6,464,957 | -16.2% | 451 | -55 | $14,334 | $69,498,217 | 5 | 20th Century Fox International | false | false |
| 2 | - | Tooth Fairy | $2,409,913 | - | 243 | - | $9,917 | $2,409,913 | 1 | 20th Century Fox International | true | false |
| 3 | 2 | It's Complicated | $2,230,657 | -28.1% | 303 | -1 | $7,361 | $7,089,071 | 2 | Universal Pictures International (UPI) | false | false |
| 4 | 3 | Sherlock Holmes | $1,620,239 | -34.2% | 288 | -19 | $5,625 | $19,370,956 | 4 | Roadshow Films | false | false |
| 5 | - | Up in the Air | $1,603,818 | - | 173 | - | $9,270 | $1,603,818 | 1 | Paramount Pictures International | true | false |
| 6 | - | Bran Nue Dae | $1,487,999 | - | 231 | - | $6,441 | $1,563,507 | 1 | Roadshow Films | true | false |
| 7 | 4 | Alvin and the Chipmunks: The Squeakquel | $1,324,389 | -37.7% | 323 | -22 | $4,100 | $17,949,332 | 4 | 20th Century Fox International | false | false |
| 8 | 6 | The Princess and the Frog | $643,586 | -36.4% | 228 | +3 | $2,822 | $4,570,415 | 3 | Walt Disney Pictures | false | false |
| 9 | 5 | Old Dogs | $565,816 | -52.4% | 236 | -19 | $2,397 | $7,775,586 | 4 | Walt Disney Pictures | false | false |
| 10 | 7 | The Lovely Bones | $503,648 | -45.9% | 182 | +4 | $2,767 | $4,972,088 | 4 | Paramount Pictures International | false | false |
| 11 | 8 | Fantastic Mr. Fox | $361,941 | -41% | 216 | -6 | $1,675 | $2,772,458 | 9 | 20th Century Fox International | false | false |
| 12 | 9 | Did You Hear About the Morgans? | $218,010 | -62.8% | 166 | -42 | $1,313 | $5,451,233 | 4 | Sony Pictures Releasing | false | false |
| 13 | 10 | Bright Star | $149,840 | -43% | 64 | -2 | $2,341 | $2,089,812 | 4 | Hopscotch Films | false | false |
| 14 | 11 | The Twilight Saga: New Moon | $113,128 | -43.5% | 62 | -62 | $1,824 | $35,164,930 | 9 | - | false | false |
| 15 | 12 | Nowhere Boy | $59,276 | -38.4% | 34 | - | $1,743 | $731,603 | 4 | Icon Film Distribution | false | false |
| 16 | 14 | Broken Embraces | $37,930 | -47.2% | 19 | -4 | $1,996 | $679,307 | 5 | Paramount Pictures International | false | false |
| 17 | 15 | Cloudy with a Chance of Meatballs | $33,480 | -41.8% | 40 | -23 | $837 | $7,487,784 | 8 | Sony Pictures Releasing | false | false |
| 18 | 13 | 3 Idiots | $32,946 | -59% | 14 | -4 | $2,353 | $994,639 | 4 | Mind Blowing Films | false | false |
| 19 | 20 | Dinosaurs Alive | $31,937 | +0.6% | 2 | - | $15,968 | $638,150 | 21 | IMAX | false | false |
| 20 | - | Chance Pe Dance | $27,705 | - | 12 | - | $2,308 | $27,705 | 1 | Mind Blowing Films | true | false |
| 21 | - | Peaceful Times | $25,744 | - | 1 | - | $25,744 | $25,744 | 1 | Potential Films | true | false |
| 22 | - | A Heavenly Vintage | $872 | - | 2 | - | $436 | $872 | 1 | Icon Film Distribution | true | false |
