| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $7,743,251 | -27.3% | 590 | +2 | $13,124 | $25,660,934 | 2 | 20th Century Fox International | false | false |
| 2 | - | Sherlock Holmes | $3,398,092 | - | 308 | - | $11,032 | $3,398,092 | 1 | Roadshow Films | true | false |
| 3 | - | Alvin and the Chipmunks: The Squeakquel | $2,935,754 | - | 363 | - | $8,087 | $2,935,754 | 1 | 20th Century Fox International | true | false |
| 4 | - | Old Dogs | $1,084,284 | - | 271 | - | $4,001 | $1,098,269 | 1 | Walt Disney Pictures | true | false |
| 5 | - | Did You Hear About the Morgans? | $996,597 | - | 196 | - | $5,084 | $996,597 | 1 | Sony Pictures Releasing | true | false |
| 6 | 2 | The Twilight Saga: New Moon | $435,734 | -49.2% | 311 | -27 | $1,401 | $32,212,895 | 6 | - | false | false |
| 7 | - | The Lovely Bones | $314,392 | - | 230 | - | $1,366 | $314,392 | 1 | Paramount Pictures International | true | false |
| 8 | - | Bright Star | $282,912 | - | 65 | - | $4,352 | $352,796 | 1 | Hopscotch Films | true | false |
| 9 | - | 3 Idiots | $264,502 | - | 20 | - | $13,225 | $264,502 | 1 | Mind Blowing Films | true | false |
| 10 | 4 | Paranormal Activity | $228,436 | -65.8% | 258 | - | $885 | $6,963,633 | 4 | Icon Film Distribution | false | false |
| 11 | 5 | Where the Wild Things Are | $216,339 | -64.9% | 251 | -11 | $861 | $4,915,522 | 4 | Roadshow Films | false | false |
| 12 | 3 | Cloudy with a Chance of Meatballs | $192,153 | -72.8% | 303 | - | $634 | $6,519,124 | 5 | Sony Pictures Releasing | false | false |
| 13 | 6 | Planet 51 | $141,388 | -72.6% | 205 | +4 | $689 | $2,105,162 | 3 | Hoyts Distribution | false | false |
| 14 | 7 | 2012 | $130,597 | -64.4% | 164 | -52 | $796 | $17,640,704 | 7 | Sony Pictures Releasing | false | false |
| 15 | - | Nowhere Boy | $90,217 | - | 33 | - | $2,733 | $142,758 | 1 | Icon Film Distribution | true | false |
| 16 | 11 | Broken Embraces | $83,405 | -26.8% | 24 | +2 | $3,475 | $241,596 | 2 | Paramount Pictures International | false | false |
| 17 | 8 | Zombieland | $55,554 | -77.3% | 145 | -7 | $383 | $2,467,594 | 4 | Sony Pictures Releasing | false | false |
| 18 | 10 | The Informant! | $50,597 | -65.2% | 55 | -1 | $919 | $1,096,358 | 4 | Warner Bros. | false | false |
| 19 | 12 | A Christmas Carol | $37,555 | -60.7% | 46 | -36 | $816 | $4,688,758 | 8 | Walt Disney Pictures | false | false |
| 20 | 9 | The Invention of Lying | $26,855 | -85.5% | 117 | - | $229 | $3,201,345 | 5 | Universal Pictures International (UPI) | false | false |
| 21 | - | The French Kissers | $25,373 | - | 16 | - | $1,585 | $57,539 | 1 | Palace Films | true | false |
