| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | This Is It | $8,018,372 | - | 498 | - | $16,101 | $8,018,372 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Up | $5,660,622 | -8.8% | 540 | -9 | $10,482 | $47,933,744 | 3 | Walt Disney Pictures | false | false |
| 3 | 3 | Fantastic Mr. Fox | $2,540,567 | +2.7% | 483 | +2 | $5,259 | $9,189,301 | 2 | 20th Century Fox International | false | false |
| 4 | 2 | Saw VI | $1,546,222 | -45.4% | 381 | +6 | $4,058 | $6,211,045 | 2 | Lionsgate | false | false |
| 5 | 5 | Cirque du Freak: The Vampire's Assistant | $895,466 | -31.2% | 386 | +1 | $2,319 | $3,789,067 | 2 | Universal Pictures International (UPI) | false | false |
| 6 | 4 | Couples Retreat | $822,441 | -45.9% | 359 | -20 | $2,290 | $8,017,665 | 3 | Universal Pictures International (UPI) | false | false |
| 7 | - | 9 | $770,156 | - | 300 | - | $2,567 | $770,156 | 1 | Universal Pictures International (UPI) | true | false |
| 8 | - | An Education | $656,170 | - | 93 | - | $7,055 | $656,170 | 1 | Entertainment One | true | false |
| 9 | 6 | The Imaginarium of Doctor Parnassus | $531,506 | -47.1% | 256 | -12 | $2,076 | $4,754,003 | 3 | Lionsgate | false | false |
| 10 | - | Dead Man Running | $326,245 | - | 80 | - | $4,078 | $326,245 | 1 | Revolver Entertainment | true | false |
| 11 | - | London Dreams | $234,640 | - | 48 | - | $4,888 | $234,640 | 1 | Studio 18 | true | false |
| 12 | - | Zombieland | $230,099 | - | 213 | - | $1,080 | $5,549,291 | 1 | Sony Pictures Releasing | true | false |
| 13 | 7 | The Invention of Lying | $229,311 | -61.2% | 203 | -104 | $1,129 | $9,814,497 | 5 | Universal Pictures International (UPI) | false | false |
| 14 | 10 | Cloudy with a Chance of Meatballs | $190,662 | -17.7% | 248 | -121 | $768 | $10,330,809 | 7 | Sony Pictures Releasing | false | false |
| 15 | 9 | Fame | $147,013 | -58.7% | 235 | -138 | $625 | $14,308,999 | 6 | Entertainment Film Distributors | false | false |
