| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Up | $6,207,306 | -26.5% | 549 | +14 | $11,306 | $32,093,401 | 2 | Walt Disney Pictures | false | false |
| 2 | - | Saw VI | $2,831,010 | - | 375 | - | $7,549 | $2,831,010 | 1 | Lionsgate | true | false |
| 3 | - | Fantastic Mr. Fox | $2,473,972 | - | 481 | - | $5,143 | $2,473,972 | 1 | 20th Century Fox International | true | false |
| 4 | 2 | Couples Retreat | $1,519,902 | -49.1% | 379 | -2 | $4,010 | $5,851,560 | 2 | Universal Pictures International (UPI) | false | false |
| 5 | - | Cirque du Freak: The Vampire's Assistant | $1,302,182 | - | 385 | - | $3,382 | $1,302,182 | 1 | Universal Pictures International (UPI) | true | false |
| 6 | 3 | The Imaginarium of Doctor Parnassus | $1,005,558 | -32.1% | 268 | +3 | $3,752 | $3,373,033 | 2 | Lionsgate | false | false |
| 7 | 4 | The Invention of Lying | $591,479 | -38.7% | 307 | -60 | $1,926 | $9,031,211 | 4 | Universal Pictures International (UPI) | false | false |
| 8 | - | Zombieland | $527,979 | - | 279 | - | $1,892 | $4,893,458 | - | Sony Pictures Releasing | - | false |
| 9 | 6 | Fame | $355,628 | -52.3% | 373 | -53 | $953 | $13,551,716 | 5 | Entertainment Film Distributors | false | false |
| 10 | 11 | Cloudy with a Chance of Meatballs | $231,548 | -32.2% | 369 | -32 | $627 | $9,590,030 | 6 | Sony Pictures Releasing | false | false |
| 11 | 7 | Triangle | $158,333 | -62.8% | 180 | -37 | $879 | $894,985 | 2 | Icon Film Distribution | false | false |
| 12 | 10 | Blue | $131,402 | -62.8% | 51 | - | $2,576 | $616,713 | 2 | N/A | false | false |
| 13 | 8 | Halloween II | $106,912 | -72.5% | 164 | -119 | $651 | $2,105,571 | 3 | Entertainment Film Distributors | false | false |
| 14 | - | Ice Age: Dawn of the Dinosaurs | $92,524 | - | 237 | - | $390 | $56,859,040 | 17 | 20th Century Fox International | false | false |
| 15 | 9 | Love Happens | $77,719 | -78.2% | 93 | -264 | $835 | $2,176,055 | 3 | Entertainment One | false | false |
