| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Final Destination | $202,863 | - | 23 | - | $8,820 | $202,863 | 1 | Roadshow Films | true | false |
| 2 | 3 | Couples Retreat | $171,277 | -27.4% | 40 | -1 | $4,281 | $476,727 | 2 | United International Pictures | false | false |
| 3 | 8 | An Education | $105,776 | +10.6% | 28 | - | $3,777 | $281,871 | 2 | Paramount Pictures International | false | false |
| 4 | 6 | 500 Days of Summer | $85,188 | -24.2% | 52 | - | $1,638 | $502,449 | 3 | 20th Century Fox International | false | false |
| 5 | 1 | Up | $78,920 | -78.4% | 82 | -3 | $962 | $2,927,344 | 6 | Walt Disney Pictures | false | false |
| 6 | 4 | Year One | $61,096 | -58% | 49 | -3 | $1,246 | $1,035,332 | 4 | Sony Pictures Releasing | false | false |
| 7 | 5 | Fighting | $51,264 | -60.4% | 33 | - | $1,553 | $209,274 | 2 | Roadshow Films | false | false |
| 8 | 2 | G-Force | $46,464 | -82.8% | 69 | -5 | $673 | $1,223,329 | 4 | Walt Disney Pictures | false | false |
| 9 | 9 | Fame | $37,641 | -60.5% | 51 | -6 | $738 | $742,531 | 4 | Hoyts Distribution | false | false |
| 10 | 10 | In the Loop | $37,074 | -23.3% | 15 | +2 | $2,471 | $215,241 | 3 | Madman Entertainment | false | false |
| 11 | - | Red Cliff | $28,003 | - | 18 | - | $1,555 | $69,051 | 1 | Hoyts Distribution | true | false |
| 12 | 12 | The Young Victoria | $22,871 | -14.2% | 39 | +4 | $586 | $695,704 | 7 | Roadshow Films | false | false |
| 13 | 7 | Aliens in the Attic | $18,747 | -82.3% | 45 | -5 | $416 | $550,582 | 5 | 20th Century Fox International | false | false |
| 14 | - | Blue | $18,634 | - | 6 | - | $3,105 | $18,634 | 1 | - | true | false |
| 15 | 13 | Inglourious Basterds | $16,370 | -15.4% | 26 | - | $629 | $1,200,866 | 9 | United International Pictures | false | false |
| 16 | - | A Pain in the Ass | $14,726 | - | 21 | - | $701 | $14,726 | 1 | Rialto Distribution | true | false |
| 17 | 15 | The September Issue | $13,392 | -20.2% | 16 | - | $837 | $296,916 | 6 | Madman Entertainment | false | false |
| 18 | 19 | North Face | $9,994 | -5% | 21 | +10 | $475 | $93,462 | 4 | Rialto Distribution | false | false |
| 19 | 14 | Funny People | $8,862 | -52.2% | 19 | -13 | $466 | $419,658 | 5 | United International Pictures | false | false |
| 20 | 16 | District 9 | $8,693 | -42.7% | 17 | -10 | $511 | $1,825,366 | 10 | Sony Pictures Releasing | false | false |
| 21 | 11 | Shorts | $7,891 | -79.8% | 25 | -8 | $315 | $194,967 | 4 | Warner Bros. | false | false |
| 22 | 18 | Samson & Delilah | $6,443 | -40.5% | 3 | -2 | $2,147 | $92,647 | 3 | Paramount Pictures International | false | false |
| 23 | - | The Damned United | $5,276 | - | 3 | - | $1,758 | $5,276 | 1 | Sony Pictures Releasing | true | false |
| 24 | 22 | Disgrace | $5,233 | -31.5% | 13 | -4 | $402 | $88,299 | 4 | Hoyts Distribution | false | false |
| 25 | 28 | Departures | $5,068 | +34.1% | 8 | -2 | $633 | $160,590 | 9 | Madman Entertainment | false | false |
| 26 | 20 | The Taking of Pelham 123 | $4,859 | -44.8% | 12 | -8 | $404 | $445,131 | 6 | Sony Pictures Releasing | false | false |
| 27 | 21 | Coco Before Chanel | $4,658 | -45.3% | 6 | -1 | $776 | $526,546 | 11 | Warner Bros. | false | false |
| 28 | 24 | Sunshine Cleaning | $4,531 | +5.9% | 21 | +2 | $215 | $445,877 | 10 | Madman Entertainment | false | false |
| 29 | 26 | Is Anybody There? | $3,825 | -3.9% | 12 | - | $318 | $113,604 | 6 | Hopscotch Films | false | false |
| 30 | 30 | Moon | $2,842 | -18% | 2 | - | $1,421 | $62,438 | 5 | Sony Pictures Releasing | false | false |
| 31 | - | Me and Mrs. Khanna | $2,593 | - | 2 | - | $1,296 | $2,593 | 1 | Mind Blowing Films | true | false |
| 32 | 25 | Chéri | $2,393 | -42.2% | 16 | -1 | $149 | $119,744 | 5 | Hoyts Distribution | false | false |
| 33 | 31 | The Strength of Water | $2,331 | -31.1% | 9 | -3 | $259 | $156,533 | 8 | Hopscotch Films | false | false |
| 34 | - | All the Best: Fun Begins | $1,822 | - | 2 | - | $911 | $1,822 | 1 | Forum Hungary | true | false |
| 35 | 43 | The Cove | $1,294 | +171.8% | 1 | -2 | $1,294 | $32,097 | 7 | Madman Entertainment | false | false |
| 36 | 27 | Do Knot Disturb | $1,052 | -72.9% | 1 | - | $1,052 | $22,452 | 3 | - | false | false |
| 37 | 35 | Ponyo | $1,006 | -22.9% | 2 | - | $503 | $55,225 | 4 | Madman Entertainment | false | false |
| 38 | 47 | Orphan | $575 | +75.8% | 3 | - | $191 | $160,436 | 8 | Warner Bros. | false | false |
| 39 | 32 | Wake Up Sid | $540 | -83.6% | 1 | -1 | $540 | $11,070 | 3 | Mind Blowing Films | false | false |
| 40 | 17 | The Founding of a Republic | $372 | -97.5% | 1 | -2 | $372 | $3,224 | 3 | Vendetta Films | false | false |
| 41 | 39 | The Hangover | $366 | -63.9% | 4 | - | $91 | $2,329,884 | 19 | Warner Bros. | false | false |
| 42 | 36 | Separation City | $318 | -75.1% | 4 | -2 | $79 | $413,233 | 11 | Hoyts Distribution | false | false |
| 43 | 50 | Bride Flight | $196 | +43.1% | 1 | -1 | $196 | $198,959 | 17 | Hopscotch Films | false | false |
| 44 | 38 | Harry Potter and the Half-Blood Prince | $86 | -92.9% | 2 | -3 | $43 | $4,390,310 | 14 | Warner Bros. | false | false |
