| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Up | $8,440,826 | - | 535 | - | $15,777 | $22,756,206 | 1 | Walt Disney Pictures | true | false |
| 2 | - | Couples Retreat | $2,984,257 | - | 381 | - | $7,832 | $2,984,257 | 1 | Universal Pictures International (UPI) | true | false |
| 3 | - | The Imaginarium of Doctor Parnassus | $1,481,035 | - | 265 | - | $5,588 | $1,481,035 | 1 | Lionsgate | true | false |
| 4 | 3 | The Invention of Lying | $964,558 | -43.8% | 367 | -2 | $2,628 | $7,925,527 | 3 | Universal Pictures International (UPI) | false | false |
| 5 | - | Zombieland | $943,331 | - | 302 | - | $3,123 | $3,827,061 | - | Sony Pictures Releasing | - | false |
| 6 | 4 | Fame | $745,105 | -48.1% | 426 | -22 | $1,749 | $12,877,923 | 4 | Entertainment Film Distributors | false | false |
| 7 | - | Triangle | $426,145 | - | 217 | - | $1,963 | $426,145 | 1 | Icon Film Distribution | true | false |
| 8 | 6 | Halloween II | $388,216 | -53.1% | 283 | -3 | $1,371 | $1,744,808 | 2 | Entertainment Film Distributors | false | false |
| 9 | 5 | Love Happens | $355,951 | -59.9% | 357 | -5 | $997 | $1,838,093 | 2 | Entertainment One | false | false |
| 10 | - | Blue | $353,116 | - | 51 | - | $6,923 | $353,116 | 1 | N/A | true | false |
| 11 | 7 | Cloudy with a Chance of Meatballs | $341,387 | -40.1% | 401 | -10 | $851 | $9,294,421 | 5 | Sony Pictures Releasing | false | false |
| 12 | 8 | Surrogates | $178,077 | -65.4% | 209 | -127 | $852 | $4,940,897 | 4 | Walt Disney Pictures | false | false |
| 13 | - | Me and Mrs. Khanna | $146,011 | - | 42 | - | $3,476 | $146,011 | 1 | UTV Motion Pictures | true | false |
| 14 | 9 | District 9 | $125,218 | -63.1% | 121 | -130 | $1,034 | $14,511,508 | 7 | Sony Pictures Releasing | false | false |
| 15 | - | Aadhavan | $94,151 | - | 11 | - | $8,559 | $94,151 | 1 | Ayngaran International | true | false |
| 16 | 16 | Creation | $43,840 | -42.9% | 51 | -24 | $859 | $1,160,359 | 4 | Icon Film Distribution | false | false |
| 17 | 15 | Dorian Gray | $26,743 | -72.5% | 40 | -62 | $668 | $4,700,705 | 6 | Momentum Pictures | false | false |
