| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Couples Retreat | $38,292,965 | - | 3,000 | - | $12,764 | $38,292,965 | 1 | Universal Pictures | true | false |
| 2 | - | Zombieland | $16,735,741 | - | 3,038 | - | $5,508 | $49,536,822 | 2 | Sony Pictures Releasing | false | false |
| 3 | - | Cloudy with a Chance of Meatballs | $14,103,377 | - | 2,992 | - | $4,713 | $98,354,333 | 4 | Sony Pictures Releasing | false | false |
| 4 | - | Paranormal Activity | $9,217,720 | - | 160 | - | $57,610 | $10,430,961 | 3 | Paramount Pictures | false | false |
| 5 | - | Toy Story 2009 Re-release | $9,081,120 | - | 1,752 | - | $5,183 | $24,083,468 | 2 | Walt Disney Studios Motion Pictures | false | false |
| 6 | - | Surrogates | $4,858,538 | - | 2,992 | - | $1,623 | $33,316,005 | 3 | Walt Disney Studios Motion Pictures | false | false |
| 7 | - | The Invention of Lying | $3,797,317 | - | 1,743 | - | $2,178 | $12,753,922 | 2 | Warner Bros. | false | false |
| 8 | - | Whip It | $3,219,021 | - | 1,738 | - | $1,852 | $9,185,079 | 2 | - | false | false |
| 9 | - | Capitalism: A Love Story | $3,027,335 | - | 995 | - | $3,042 | $9,422,526 | 3 | Overture Films | false | false |
| 10 | - | Fame | $2,928,854 | - | 3,110 | - | $941 | $20,414,616 | 3 | Metro-Goldwyn-Mayer (MGM) | false | false |
| 11 | - | The Informant! | $2,518,536 | - | 2,202 | - | $1,143 | $30,161,684 | 4 | Warner Bros. | false | false |
| 12 | - | I Can Do Bad All by Myself | $1,697,757 | - | 1,313 | - | $1,293 | $50,569,414 | 5 | Lionsgate | false | false |
| 13 | - | Love Happens | $1,656,430 | - | 1,894 | - | $874 | $21,441,845 | 4 | Universal Pictures | false | false |
| 14 | - | Good Hair | $1,173,714 | - | 186 | - | $6,310 | $1,173,714 | 1 | Roadside Attractions | true | false |
| 15 | - | Inglourious Basterds | $993,705 | - | 968 | - | $1,026 | $118,442,404 | 8 | The Weinstein Company | false | false |
| 16 | - | 9 | $964,081 | - | 1,216 | - | $792 | $30,794,053 | 5 | Focus Features | false | false |
| 17 | - | Pandorum | $948,189 | - | 1,479 | - | $641 | $9,643,575 | 3 | Overture Films | false | false |
| 18 | - | G.I. Joe: The Rise of Cobra | $779,836 | - | 609 | - | $1,280 | $149,061,473 | 10 | Paramount Pictures | false | false |
| 19 | - | All About Steve | $731,795 | - | 1,200 | - | $609 | $32,814,360 | 6 | Twentieth Century Fox | false | false |
| 20 | - | Bright Star | $718,886 | - | 380 | - | $1,891 | $2,940,973 | 4 | Apparition | false | false |
| 21 | - | Jennifer's Body | $633,527 | - | 1,005 | - | $630 | $15,787,177 | 4 | Twentieth Century Fox | false | false |
| 22 | - | A Serious Man | $527,978 | - | 21 | - | $25,141 | $879,964 | 2 | Focus Features | false | false |
| 23 | - | The Hangover | $482,231 | - | 471 | - | $1,023 | $275,868,349 | 19 | Warner Bros. | false | false |
| 24 | - | Harry Potter and the Half-Blood Prince | $470,306 | - | 505 | - | $931 | $300,761,086 | 13 | Warner Bros. | false | false |
| 25 | - | Julie & Julia | $465,762 | - | 594 | - | $784 | $92,600,584 | 10 | Sony Pictures Releasing | false | false |
| 26 | - | From Mexico with Love | $363,361 | - | 279 | - | $1,302 | $363,361 | 1 | Roadside Attractions | true | false |
| 27 | - | The Final Destination | $312,015 | - | 365 | - | $854 | $65,917,219 | 7 | Warner Bros. | false | false |
| 28 | - | District 9 | $290,909 | - | 333 | - | $873 | $114,873,680 | 9 | TriStar Pictures | false | false |
| 29 | - | I Hope They Serve Beer in Hell | $218,577 | - | 266 | - | $821 | $1,216,447 | 3 | Freestyle Releasing | false | false |
| 30 | - | Wake Up Sid | $216,279 | - | 76 | - | $2,845 | $631,501 | 2 | UTV Motion Pictures | false | false |
| 31 | - | The Time Traveler's Wife | $205,631 | - | 263 | - | $781 | $62,515,933 | 9 | Warner Bros. | false | false |
| 32 | - | The Boys Are Back | $204,986 | - | 75 | - | $2,733 | $350,422 | 3 | Miramax | false | false |
| 33 | - | Sorority Row | $194,055 | - | 347 | - | $559 | $11,696,661 | 5 | Summit Entertainment | false | false |
| 34 | - | Ice Age: Dawn of the Dinosaurs | $187,933 | - | 227 | - | $827 | $195,945,497 | 15 | Twentieth Century Fox | false | false |
| 35 | - | The September Issue | $187,346 | - | 104 | - | $1,801 | $3,199,359 | 7 | Roadside Attractions | false | false |
| 36 | - | More Than a Game | $147,835 | - | 44 | - | $3,359 | $368,699 | 2 | Lionsgate | false | false |
| 37 | - | Halloween II | $130,142 | - | 192 | - | $677 | $32,506,652 | 7 | - | false | false |
| 38 | - | Under the Sea 3D | $128,294 | - | 35 | - | $3,665 | $17,985,837 | 35 | Warner Bros. | false | false |
| 39 | - | Aliens in the Attic | $117,215 | - | 154 | - | $761 | $24,983,204 | 11 | Twentieth Century Fox | false | false |
| 40 | - | 500 Days of Summer | $102,487 | - | 159 | - | $644 | $32,132,024 | 13 | - | false | false |
| 41 | - | Transformers: Revenge of the Fallen | $90,761 | - | 151 | - | $601 | $402,088,378 | 16 | DreamWorks | false | false |
| 42 | - | My One and Only | $81,039 | - | 149 | - | $543 | $2,325,123 | 8 | Freestyle Releasing | false | false |
| 43 | - | Do Knot Disturb | $58,711 | - | 42 | - | $1,397 | $213,525 | 2 | Adlabs Films | false | false |
| 44 | - | Whiteout | $48,929 | - | 150 | - | $326 | $10,148,142 | 5 | Warner Bros. | false | false |
| 45 | - | Shorts | $34,814 | - | 104 | - | $334 | $20,390,930 | 8 | Warner Bros. | false | false |
| 46 | - | Night at the Museum: Battle of the Smithsonian | $27,472 | - | 39 | - | $704 | $177,207,985 | 21 | Twentieth Century Fox | false | false |
| 47 | - | The Hurt Locker | $23,718 | - | 45 | - | $527 | $12,574,562 | 16 | Summit Entertainment | false | false |
| 48 | - | Adam | $17,283 | - | 26 | - | $664 | $2,240,869 | 11 | - | false | false |
| 49 | - | Extract | $16,967 | - | 46 | - | $368 | $10,816,348 | 6 | Miramax | false | false |
| 50 | - | What's Your Raashee? | $11,206 | - | 14 | - | $800 | $255,810 | 3 | UTV Motion Pictures | false | false |
| 51 | - | The Other Man | $7,583 | - | 9 | - | $842 | $142,291 | 5 | Image Entertainment | false | false |
| 52 | - | The Cove | $7,478 | - | 18 | - | $415 | $817,413 | 11 | Roadside Attractions | false | false |
| 53 | - | Chelsea on the Rocks | $3,224 | - | 1 | - | $3,224 | $9,912 | 2 | Aliquot Films | false | false |
| 54 | - | Paper Heart | $2,483 | - | 18 | - | $137 | $1,257,504 | 10 | Overture Films | false | false |
| 55 | - | American Casino | $920 | - | 1 | - | $920 | $45,752 | 9 | Argot Pictures | false | false |
| 56 | - | Goodbye Solo | $892 | - | 3 | - | $297 | $870,458 | 29 | Roadside Attractions | false | false |
| 57 | - | The Stoning of Soraya M. | $332 | - | 2 | - | $166 | $633,499 | 16 | Roadside Attractions | false | false |
