| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Ugly Truth | $33,703 | - | 4 | - | $8,425 | $33,703 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | The Final Destination | $20,546 | -43% | 1 | - | $20,546 | $88,623 | 2 | - | false | false |
| 3 | 2 | High Security Vacation | $6,143 | -29.7% | 2 | - | $3,071 | $80,828 | 5 | ACME | false | false |
| 4 | 4 | Inglourious Basterds | $6,139 | -21.9% | 3 | - | $2,046 | $149,009 | 6 | - | false | false |
| 5 | 3 | Up | $4,986 | -41.1% | 9 | - | $554 | $235,559 | 8 | - | false | false |
| 6 | - | Fame | $4,563 | - | 2 | - | $2,281 | $4,563 | 1 | - | true | false |
| 7 | 8 | Taking Woodstock | $3,350 | -20.4% | 1 | - | $3,350 | $12,779 | 2 | ACME | false | false |
| 8 | 6 | Gamer | $3,195 | -39.7% | 2 | - | $1,597 | $33,199 | 3 | ACME | false | false |
| 9 | 9 | Broken Embraces | $3,092 | -13% | 2 | - | $1,546 | $44,256 | 5 | - | false | false |
| 10 | 7 | Spread | $2,865 | -36.2% | 1 | - | $2,865 | $86,641 | 6 | ACME | false | false |
| 11 | 5 | The Proposal | $2,401 | -55.6% | 3 | - | $800 | $204,986 | 12 | - | false | false |
| 12 | 11 | The Hangover | $2,191 | -24% | 3 | - | $730 | $235,435 | 16 | - | false | false |
| 13 | 13 | Whatever Works | $2,088 | -4.9% | 1 | - | $2,088 | $25,367 | 4 | - | false | false |
| 14 | 15 | Ice Age: Dawn of the Dinosaurs | $1,956 | -8.6% | 12 | - | $163 | $793,393 | 13 | - | false | false |
| 15 | 12 | Coraline | $1,778 | -38.3% | 1 | - | $1,778 | $26,736 | 4 | - | false | false |
| 16 | 14 | District 13: Ultimatum | $1,557 | -27.7% | 1 | - | $1,557 | $5,867 | 2 | N/A | false | false |
| 17 | 10 | District 9 | $1,044 | -68.1% | 5 | - | $208 | $75,314 | 5 | Sony Pictures Releasing | false | false |
| 18 | 16 | Harry Potter and the Half-Blood Prince | $741 | -48.5% | 6 | - | $123 | $249,048 | 10 | - | false | false |
