| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 4 | Cloudy with a Chance of Meatballs | $164,873 | +317.9% | 50 | +40 | $3,297 | $354,487 | 2 | Sony Pictures Releasing | false | false |
| 2 | 1 | The Taking of Pelham 123 | $69,578 | +12.3% | 33 | - | $2,108 | $278,137 | 3 | Sony Pictures Releasing | false | false |
| 3 | 2 | Orphan | $63,571 | +17.7% | 25 | +2 | $2,542 | $514,489 | 5 | Warner Bros. | false | false |
| 4 | 3 | Dawson Isla 10 | $59,482 | +13.8% | 20 | - | $2,974 | $246,594 | 3 | N/A | false | false |
| 5 | 5 | The Ugly Truth | $45,330 | +24.5% | 23 | -2 | $1,970 | $256,233 | 4 | Sony Pictures Releasing | false | false |
| 6 | 6 | The Hangover | $40,569 | +27.1% | 27 | +1 | $1,502 | $458,204 | 6 | Warner Bros. | false | false |
| 7 | 7 | Tinker Bell and the Lost Treasure | $27,481 | +4% | 31 | -2 | $886 | $205,135 | 4 | Walt Disney Pictures | false | false |
| 8 | - | My Sister's Keeper | $22,781 | - | 8 | - | $2,847 | $22,859 | 1 | Warner Bros. | true | false |
| 9 | 8 | G-Force | $20,675 | -15.4% | 25 | -7 | $827 | $1,480,444 | 10 | Walt Disney Pictures | false | false |
| 10 | 9 | Aliens in the Attic | $20,617 | -8.8% | 28 | -3 | $736 | $255,466 | 5 | 20th Century Fox International | false | false |
| 11 | 10 | The Maid | $18,039 | +24.1% | 19 | - | $949 | $395,645 | 7 | Andes Films | false | false |
| 12 | 13 | Boogeyman 2 | $13,322 | +71.1% | 4 | -8 | $3,330 | $60,737 | 4 | N/A | false | false |
| 13 | 11 | Last Chance Harvey | $12,902 | +7.9% | 7 | -3 | $1,843 | $122,956 | 5 | N/A | false | false |
| 14 | 12 | The Time Traveler's Wife | $9,327 | +15% | 6 | - | $1,554 | $37,655 | 3 | Warner Bros. | false | false |
| 15 | 15 | Lorna's Silence | $5,951 | +12.9% | 3 | - | $1,983 | $13,289 | 2 | N/A | false | false |
| 16 | 14 | New in Town | $5,837 | +6.2% | 6 | -2 | $972 | $27,507 | 3 | N/A | false | false |
| 17 | - | Goodbye Bafana | $5,382 | - | 4 | - | $1,345 | $5,382 | 1 | N/A | true | false |
| 18 | 16 | The Class | $4,694 | +21.4% | 2 | - | $2,347 | $9,517 | 2 | N/A | false | false |
| 19 | 19 | Ice Age: Dawn of the Dinosaurs | $3,331 | +44.8% | 14 | +4 | $237 | $7,059,357 | 13 | 20th Century Fox International | false | false |
| 20 | 21 | Che: Part Two | $3,089 | +45.6% | 6 | +3 | $514 | $22,483 | 4 | N/A | false | false |
| 21 | 17 | Transporter 3 | $2,936 | -7.7% | 5 | -1 | $587 | $37,638 | 5 | N/A | false | false |
| 22 | 18 | The Proposal | $2,782 | +8% | 2 | - | $1,391 | $290,226 | 8 | Walt Disney Pictures | false | false |
| 23 | 22 | Harry Potter and the Half-Blood Prince | $2,161 | +1.9% | 4 | - | $540 | $3,490,188 | 11 | Warner Bros. | false | false |
| 24 | 23 | Public Enemies | $1,815 | -12.9% | 3 | -2 | $605 | $497,563 | 9 | United International Pictures | false | false |
| 25 | 28 | Bangkok Dangerous | $1,787 | +527% | 6 | +3 | $297 | $86,710 | 7 | N/A | false | false |
| 26 | 24 | The Visitor | $1,457 | -8.1% | 2 | - | $728 | $16,794 | 4 | N/A | false | false |
| 27 | 20 | Shorts | $1,070 | -52.7% | 4 | -2 | $267 | $229,068 | 8 | Warner Bros. | false | false |
| 28 | 27 | G.I. Joe: The Rise of Cobra | $969 | +48.4% | 2 | - | $484 | $420,139 | 8 | United International Pictures | false | false |
| 29 | 25 | Up | $867 | -16.3% | 4 | - | $216 | $3,645,572 | 16 | Walt Disney Pictures | false | false |
| 30 | 26 | My Bloody Valentine | $808 | +10.1% | 3 | +1 | $269 | $102,971 | 6 | N/A | false | false |
