| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Taking of Pelham 123 | $61,957 | -25.9% | 33 | - | $1,877 | $184,590 | 2 | Sony Pictures Releasing | false | false |
| 2 | 3 | Orphan | $54,020 | -22.3% | 23 | - | $2,348 | $428,370 | 4 | Warner Bros. | false | false |
| 3 | 2 | Dawson Isla 10 | $52,250 | -34.2% | 20 | -1 | $2,612 | $166,355 | 2 | N/A | false | false |
| 4 | - | Cloudy with a Chance of Meatballs | $39,449 | - | 10 | - | $3,944 | $39,449 | 1 | Sony Pictures Releasing | true | false |
| 5 | 4 | The Ugly Truth | $36,398 | -26.3% | 25 | - | $1,455 | $195,722 | 3 | Sony Pictures Releasing | false | false |
| 6 | 5 | The Hangover | $31,925 | -23.4% | 26 | -3 | $1,227 | $404,257 | 5 | Warner Bros. | false | false |
| 7 | 6 | Tinker Bell and the Lost Treasure | $26,430 | -35.4% | 33 | - | $800 | $171,530 | 3 | Walt Disney Pictures | false | false |
| 8 | 8 | G-Force | $24,447 | -20.3% | 32 | -10 | $763 | $1,453,693 | 9 | Walt Disney Pictures | false | false |
| 9 | 7 | Aliens in the Attic | $22,618 | -38.9% | 31 | -1 | $729 | $229,628 | 4 | 20th Century Fox International | false | false |
| 10 | 9 | The Maid | $14,541 | -30% | 19 | -1 | $765 | $372,383 | 6 | Andes Films | false | false |
| 11 | 10 | Last Chance Harvey | $11,959 | -31.3% | 10 | -2 | $1,195 | $106,248 | 4 | N/A | false | false |
| 12 | 12 | The Time Traveler's Wife | $8,111 | -31.8% | 6 | - | $1,351 | $25,356 | 2 | Warner Bros. | false | false |
| 13 | 14 | Boogeyman 2 | $7,786 | -11.8% | 12 | -3 | $648 | $44,619 | 3 | N/A | false | false |
| 14 | 13 | New in Town | $5,497 | -44.6% | 8 | - | $687 | $20,168 | 2 | N/A | false | false |
| 15 | - | Lorna's Silence | $5,272 | - | 3 | - | $1,757 | $5,353 | 1 | N/A | true | false |
| 16 | - | The Class | $3,868 | - | 2 | - | $1,934 | $3,931 | 1 | N/A | true | false |
| 17 | 26 | Transporter 3 | $3,180 | +133.7% | 6 | +2 | $530 | $33,191 | 4 | N/A | false | false |
| 18 | 15 | The Proposal | $2,576 | -63.5% | 2 | -8 | $1,288 | $286,819 | 7 | Walt Disney Pictures | false | false |
| 19 | 11 | Ice Age: Dawn of the Dinosaurs | $2,300 | -82.1% | 10 | -14 | $230 | $6,878,436 | 12 | 20th Century Fox International | false | false |
| 20 | 17 | Shorts | $2,261 | -63.3% | 6 | -6 | $376 | $227,735 | 7 | Warner Bros. | false | false |
| 21 | 19 | Che: Part Two | $2,121 | -44.9% | 3 | -3 | $707 | $18,613 | 3 | N/A | false | false |
| 22 | 22 | Harry Potter and the Half-Blood Prince | $2,120 | -9.4% | 4 | -3 | $530 | $3,487,581 | 10 | Warner Bros. | false | false |
| 23 | 16 | Public Enemies | $2,083 | -69.2% | 5 | -4 | $416 | $494,603 | 8 | United International Pictures | false | false |
| 24 | 21 | The Visitor | $1,586 | -44.5% | 2 | -1 | $793 | $14,677 | 3 | N/A | false | false |
| 25 | 27 | Up | $1,036 | +272.7% | 4 | +3 | $259 | $3,644,680 | 15 | Walt Disney Pictures | false | false |
| 26 | 18 | My Bloody Valentine | $734 | -85.5% | 2 | -7 | $367 | $101,865 | 5 | N/A | false | false |
| 27 | 25 | G.I. Joe: The Rise of Cobra | $653 | -53.8% | 2 | -4 | $326 | $418,868 | 7 | United International Pictures | false | false |
| 28 | 23 | Bangkok Dangerous | $285 | -86.8% | 3 | -9 | $95 | $84,599 | 6 | N/A | false | false |
| 29 | 20 | The Edge of Heaven | $237 | -93.6% | 1 | -2 | $237 | $4,615 | 2 | Transeuropa | false | false |
