| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Gamer | $12,196 | - | 2 | - | $6,098 | $12,196 | 1 | ACME | true | false |
| 2 | 1 | Inglourious Basterds | $11,343 | -37% | 3 | - | $3,781 | $120,010 | 4 | - | false | false |
| 3 | 3 | Up | $10,423 | -18.6% | 9 | - | $1,158 | $215,838 | 6 | - | false | false |
| 4 | 2 | High Security Vacation | $8,346 | -41.2% | 2 | -1 | $4,173 | $55,931 | 3 | ACME | false | false |
| 5 | 4 | District 9 | $6,312 | -49.2% | 5 | - | $1,262 | $65,136 | 3 | Sony Pictures Releasing | false | false |
| 6 | 6 | Spread | $6,262 | -20.9% | 1 | - | $6,262 | $69,212 | 4 | ACME | false | false |
| 7 | 8 | The Proposal | $5,531 | -23.6% | 3 | - | $1,843 | $188,973 | 10 | - | false | false |
| 8 | 5 | Coraline | $4,784 | -48.5% | 1 | - | $4,784 | $17,312 | 2 | - | false | false |
| 9 | 10 | Whatever Works | $4,261 | -33.6% | 1 | - | $4,261 | $14,711 | 2 | - | false | false |
| 10 | 9 | Ice Age: Dawn of the Dinosaurs | $3,883 | -45.8% | 12 | - | $323 | $791,984 | 11 | - | false | false |
| 11 | 7 | Broken Embraces | $3,726 | -51.1% | 2 | - | $1,863 | $29,507 | 3 | - | false | false |
| 12 | 14 | The Hangover | $3,149 | +7.9% | 3 | - | $1,049 | $226,172 | 14 | - | false | false |
| 13 | 11 | Harry Potter and the Half-Blood Prince | $2,547 | -37% | 6 | - | $424 | $246,074 | 8 | - | false | false |
| 14 | 13 | The Taking of Pelham 123 | $1,704 | -48.8% | 2 | - | $852 | $52,074 | 6 | Sony Pictures Releasing | false | false |
| 15 | 12 | G.I. Joe: The Rise of Cobra | $1,359 | -60.4% | 3 | - | $453 | $64,299 | 5 | - | false | false |
