| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Up | $648,726 | - | 91 | - | $7,128 | $648,726 | 1 | Walt Disney Pictures | true | false |
| 2 | - | The Final Destination | $424,403 | - | 34 | - | $12,482 | $424,403 | 1 | Roadshow Films | true | false |
| 3 | 1 | Harry Potter and the Half-Blood Prince | $199,757 | -59.2% | 94 | -50 | $2,125 | $3,189,240 | 3 | Warner Bros. | false | false |
| 4 | 3 | Inglourious Basterds | $164,457 | -31.9% | 57 | -9 | $2,885 | $1,915,314 | 4 | United International Pictures | false | false |
| 5 | 2 | Gamer | $140,084 | -51.9% | 35 | -9 | $4,002 | $564,409 | 2 | Odeon | false | false |
| 6 | - | Drag Me to Hell | $72,988 | - | 17 | - | $4,293 | $72,988 | 1 | Spentzos Films | true | false |
| 7 | - | 9 | $66,560 | - | 21 | - | $3,169 | $66,560 | 1 | Odeon | true | false |
| 8 | 4 | Ice Age: Dawn of the Dinosaurs | $50,249 | -50.6% | 43 | -1 | $1,168 | $4,583,462 | 11 | 20th Century Fox International | false | false |
| 9 | - | Spread | $40,773 | - | 10 | - | $4,077 | $40,773 | 1 | Hollywood Entertainment | true | false |
| 10 | 5 | The Soloist | $31,550 | -68.3% | 26 | - | $1,213 | $158,575 | 2 | United International Pictures | false | false |
| 11 | 11 | The Taking of Pelham 123 | $2,799 | -28.7% | 5 | - | $559 | $510,166 | 8 | Sony Pictures Releasing | false | false |
