| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Up | $1,498,657 | -24.2% | 324 | -5 | $4,625 | $4,916,807 | 2 | Walt Disney Pictures | false | false |
| 2 | 2 | So Normal 2: The Craziest Night Ever | $1,030,795 | -27.5% | 393 | +9 | $2,622 | $6,123,301 | 3 | N/A | false | false |
| 3 | 3 | The Taking of Pelham 123 | $618,177 | -29.8% | 181 | - | $3,415 | $2,131,144 | 2 | Sony Pictures Releasing | false | false |
| 4 | 4 | The Hangover | $573,441 | -7.1% | 183 | - | $3,133 | $4,111,784 | 4 | Warner Bros. | false | false |
| 5 | - | My Sister's Keeper | $292,067 | - | 93 | - | $3,140 | $292,067 | 1 | PlayArte Pictures | true | false |
| 6 | - | My Life in Ruins | $275,044 | - | 121 | - | $2,273 | $275,044 | 1 | N/A | true | false |
| 7 | 5 | G-Force | $95,505 | -49.7% | 214 | -7 | $446 | $3,763,195 | 5 | Walt Disney Pictures | false | false |
| 8 | 6 | Orphan | $94,697 | -44.7% | 77 | -4 | $1,229 | $391,885 | 2 | Warner Bros. | false | false |
| 9 | - | Bandslam | $62,390 | - | 81 | - | $770 | $62,390 | 1 | Paris Filmes | true | false |
| 10 | 7 | Two Lovers | $49,448 | -43.7% | 41 | -6 | $1,206 | $396,516 | 3 | PlayArte Pictures | false | false |
| 11 | 8 | Drag Me to Hell | $27,944 | -65% | 108 | -38 | $258 | $1,614,937 | 5 | Universal Pictures International (UPI) | false | false |
| 12 | 9 | Brüno | $25,015 | -46% | 47 | -13 | $532 | $1,100,019 | 5 | Sony Pictures Releasing | false | false |
| 13 | 12 | The Proposal | $20,756 | -46.7% | 57 | -28 | $364 | $6,781,304 | 10 | Walt Disney Pictures | false | false |
| 14 | 15 | Antichrist | $20,703 | -27.9% | 11 | -3 | $1,882 | $138,290 | 3 | N/A | false | false |
| 15 | 10 | G.I. Joe: The Rise of Cobra | $18,011 | -58.6% | 61 | -71 | $295 | $3,241,724 | 6 | Paramount Pictures International | false | false |
| 16 | 19 | The Wave | $18,009 | +24% | 15 | -2 | $1,200 | $106,641 | 4 | N/A | false | false |
| 17 | 13 | Shorts | $17,478 | -51.8% | 59 | -1 | $296 | $193,216 | 3 | Warner Bros. | false | false |
| 18 | 11 | Ice Age: Dawn of the Dinosaurs | $16,647 | -61.4% | 75 | -27 | $221 | $42,278,634 | 11 | 20th Century Fox International | false | false |
| 19 | 14 | Harry Potter and the Half-Blood Prince | $16,631 | -51% | 30 | -15 | $554 | $18,861,509 | 9 | Warner Bros. | false | false |
| 20 | 22 | Time of Peace | $10,716 | +0.4% | 30 | +3 | $357 | $355,947 | 5 | N/A | false | false |
| 21 | 20 | Last Chance Harvey | $9,540 | -24.3% | 23 | +4 | $414 | $769,560 | 13 | N/A | false | false |
| 22 | 29 | Doomsday | $8,033 | +163.8% | 26 | +7 | $308 | $149,573 | 4 | Europa Filmes | false | false |
| 23 | 17 | The Story of Me | $6,745 | -57.7% | 34 | -18 | $198 | $520,086 | 6 | Warner Bros. | false | false |
| 24 | 18 | The Invisible Woman | $6,548 | -55% | 27 | -21 | $242 | $10,649,635 | 15 | Warner Bros. | false | false |
| 25 | 26 | The Butterfly Effect 3: Revelations | $6,447 | +4.8% | 24 | +6 | $268 | $590,571 | 7 | N/A | false | false |
| 26 | 28 | Giant | $5,469 | +48.9% | 8 | +1 | $683 | $48,080 | 4 | N/A | false | false |
| 27 | 21 | The Accidental Husband | $5,154 | -52% | 31 | -20 | $166 | $1,043,280 | 6 | PlayArte Pictures | false | false |
| 28 | 27 | Departures | $5,106 | +30.3% | 9 | +1 | $567 | $390,434 | 15 | Paris Filmes | false | false |
| 29 | 25 | Adrift | $4,699 | -24.6% | 18 | -1 | $261 | $405,680 | 7 | Universal Pictures International (UPI) | false | false |
| 30 | 23 | Veronika Decides to Die | $4,541 | -31.4% | 22 | +5 | $206 | $163,776 | 4 | N/A | false | false |
| 31 | 16 | The Wedding Song | $4,064 | -75.3% | 12 | -3 | $338 | $32,993 | 2 | Paris Filmes | false | false |
| 32 | 24 | Public Enemies | $2,484 | -60.4% | 15 | -8 | $165 | $2,694,614 | 8 | Universal Pictures International (UPI) | false | false |
| 33 | 30 | Halloween | $1,491 | -49.5% | 14 | -1 | $106 | $732,949 | 8 | PlayArte Pictures | false | false |
| 34 | 32 | The International | $496 | -68% | 5 | -5 | $99 | $622,126 | 13 | Sony Pictures Releasing | false | false |
| 35 | 34 | Hannah Montana: The Movie | $372 | -17% | 4 | -1 | $93 | $2,610,515 | 14 | Walt Disney Pictures | false | false |
| 36 | 38 | Frozen River | $97 | +27.6% | 2 | - | $48 | $49,253 | 30 | Sony Pictures Releasing | false | false |
| 37 | 37 | Waltz with Bashir | $29 | -68.5% | 1 | -1 | $29 | $111,048 | 24 | Sony Pictures Releasing | false | false |
