| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Up | $2,216,181 | +23.4% | 308 | +90 | $7,195 | $4,798,090 | 2 | Buena Vista International | false | false |
| 2 | - | Funny People | $1,546,090 | - | 241 | - | $6,415 | $1,555,577 | 1 | Universal Pictures International (UPI) | true | false |
| 3 | 2 | Inglourious Basterds | $810,281 | -35.6% | 260 | - | $3,116 | $8,952,172 | 4 | Universal Pictures International (UPI) | false | false |
| 4 | 4 | Aliens in the Attic | $532,875 | -25.5% | 215 | - | $2,478 | $1,406,711 | 2 | 20th Century Fox International | false | false |
| 5 | 5 | Charlie & Boots | $498,990 | -26.7% | 181 | -1 | $2,756 | $1,524,177 | 2 | Paramount Pictures International | false | false |
| 6 | 3 | The Taking of Pelham 123 | $482,552 | -48.6% | 243 | -5 | $1,985 | $3,813,471 | 3 | Sony Pictures Releasing | false | false |
| 7 | 6 | The Young Victoria | $399,796 | -28.6% | 124 | - | $3,224 | $2,384,139 | 3 | Roadshow Films | false | false |
| 8 | - | Push | $284,505 | - | 129 | - | $2,205 | $284,505 | 1 | Icon Film Distribution | true | false |
| 9 | 7 | District 9 | $283,463 | -46% | 126 | -42 | $2,249 | $6,294,100 | 5 | Sony Pictures Releasing | false | false |
| 10 | 8 | The Ugly Truth | $218,159 | -52.3% | 159 | -75 | $1,372 | $10,278,423 | 6 | Sony Pictures Releasing | false | false |
| 11 | - | Sorority Row | $184,761 | - | 119 | - | $1,552 | $184,761 | 1 | Hoyts Distribution | true | false |
| 12 | - | 500 Days of Summer | $148,122 | - | 200 | - | $740 | $148,122 | - | 20th Century Fox International | - | false |
| 13 | 9 | The Soloist | $144,863 | -50% | 97 | - | $1,493 | $573,226 | 2 | Universal Pictures International (UPI) | false | false |
| 14 | 10 | My Sister's Keeper | $140,606 | -43.4% | 134 | -45 | $1,049 | $7,864,680 | 7 | Roadshow Films | false | false |
| 15 | 14 | The September Issue | $131,231 | +3.9% | 37 | +12 | $3,546 | $801,698 | 4 | Madman Entertainment | false | false |
| 16 | 11 | G.I. Joe: The Rise of Cobra | $95,951 | -58.1% | 91 | -60 | $1,054 | $6,818,543 | 6 | Paramount Pictures International | false | false |
| 17 | 13 | Harry Potter and the Half-Blood Prince | $94,449 | -50.6% | 20 | -112 | $4,722 | $34,635,745 | 9 | Warner Bros. | false | false |
| 18 | 18 | Balibo | $92,536 | +28.1% | 49 | +14 | $1,888 | $818,902 | 5 | Paramount Pictures International | false | false |
| 19 | 12 | Fighting | $63,938 | -70.3% | 76 | -26 | $841 | $892,384 | 3 | Roadshow Films | false | false |
| 20 | 16 | Ponyo | $63,811 | -27.9% | 39 | +1 | $1,636 | $329,877 | 3 | Madman Entertainment | false | false |
| 21 | - | Blessed | $57,985 | - | 15 | - | $3,865 | $65,123 | 1 | Icon Film Distribution | true | false |
| 22 | - | Anvil: The Story of Anvil | $18,628 | - | 12 | - | $1,552 | $18,628 | 1 | Roadshow Films | true | false |
| 23 | - | Shorts | $949 | - | 5 | - | $189 | $1,918 | - | Warner Bros. | - | false |
