| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Inglourious Basterds | $953,860 | -16.2% | 80 | +2 | $11,923 | $2,710,517 | 2 | Universal Pictures International (UPI) | false | false |
| 2 | - | The Final Destination | $652,536 | - | 57 | - | $11,448 | $691,759 | 1 | Warner Bros. | true | false |
| 3 | 2 | Harry Potter and the Half-Blood Prince | $269,734 | -30.1% | 162 | -12 | $1,665 | $15,552,850 | 8 | Warner Bros. | false | false |
| 4 | 4 | My Sister's Keeper | $201,264 | -18.9% | 38 | +1 | $5,296 | $567,826 | 2 | Warner Bros. | false | false |
| 5 | 6 | G-Force | $191,526 | +15% | 105 | +1 | $1,824 | $2,260,843 | 6 | Walt Disney Pictures | false | false |
| 6 | 3 | The Taking of Pelham 123 | $179,706 | -32.9% | 70 | - | $2,567 | $1,095,134 | 3 | Sony Pictures Releasing | false | false |
| 7 | 5 | Ice Age: Dawn of the Dinosaurs | $175,907 | -17.6% | 140 | -28 | $1,256 | $12,170,240 | 10 | 20th Century Fox International | false | false |
| 8 | 8 | The Girl with the Dragon Tattoo | $126,040 | <0.1% | 40 | +1 | $3,151 | $984,009 | 5 | Benelux Film Distributors | false | false |
| 9 | - | Funny People | $107,646 | - | 30 | - | $3,588 | $141,977 | 1 | Universal Pictures International (UPI) | true | false |
| 10 | 9 | Public Enemies | $91,127 | -25.3% | 75 | -5 | $1,215 | $2,334,196 | 6 | Universal Pictures International (UPI) | false | false |
| 11 | 10 | The Hangover | $82,677 | -12.2% | 47 | -5 | $1,759 | $4,915,451 | 13 | Warner Bros. | false | false |
| 12 | 12 | Broken Embraces | $76,083 | +0.2% | 23 | - | $3,307 | $197,801 | 2 | Cinéart | false | false |
| 13 | 7 | G.I. Joe: The Rise of Cobra | $75,514 | -47.2% | 67 | -13 | $1,127 | $1,246,290 | 4 | United International Pictures | false | false |
| 14 | 11 | The Proposal | $65,120 | -23.1% | 55 | -5 | $1,184 | $4,135,553 | 12 | Walt Disney Pictures | false | false |
| 15 | 15 | Lilly the Witch: The Dragon and the Magic Book | $59,449 | +20.7% | 50 | - | $1,188 | $199,849 | 3 | RCV Film Distribution | false | false |
| 16 | 16 | Het geheim van Mega Mindy | $52,876 | +9.8% | 93 | -2 | $568 | $2,138,347 | 9 | Independent Films | false | false |
| 17 | 13 | Bandslam | $50,521 | -28.3% | 40 | - | $1,263 | $178,583 | 2 | Independent Films | false | false |
| 18 | 20 | Luke and Lucy: The Texas Rangers | $40,136 | +16.3% | 83 | -3 | $483 | $780,997 | 7 | RCV Film Distribution | false | false |
| 19 | 19 | The Indian | $35,634 | -0.7% | 70 | +1 | $509 | $315,630 | 4 | A-Film Distribution | false | false |
| 20 | 14 | Hannah Montana: The Movie | $34,784 | -41.1% | 30 | - | $1,159 | $268,539 | 3 | Walt Disney Pictures | false | false |
