| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Up | $1,795,243 | - | 218 | - | $8,235 | $2,084,047 | 1 | Buena Vista International | true | false |
| 2 | 1 | Inglourious Basterds | $1,257,928 | -29.6% | 260 | -6 | $4,838 | $7,516,401 | 3 | Universal Pictures International (UPI) | false | false |
| 3 | 2 | The Taking of Pelham 123 | $939,567 | -34.7% | 248 | +2 | $3,788 | $2,934,019 | 2 | Sony Pictures Releasing | false | false |
| 4 | - | Aliens in the Attic | $715,479 | - | 215 | - | $3,327 | $716,611 | 1 | 20th Century Fox International | true | false |
| 5 | - | Charlie & Boots | $680,519 | - | 182 | - | $3,739 | $685,056 | 1 | Paramount Pictures International | true | false |
| 6 | 4 | The Young Victoria | $559,731 | -23.4% | 124 | - | $4,513 | $1,676,299 | 2 | Roadshow Films | false | false |
| 7 | 5 | District 9 | $524,476 | -26.9% | 168 | -4 | $3,121 | $5,724,574 | 4 | Sony Pictures Releasing | false | false |
| 8 | 3 | The Ugly Truth | $457,835 | -41.5% | 234 | -25 | $1,956 | $9,736,832 | 5 | Sony Pictures Releasing | false | false |
| 9 | - | The Soloist | $289,779 | - | 97 | - | $2,987 | $294,889 | 1 | Universal Pictures International (UPI) | true | false |
| 10 | 6 | My Sister's Keeper | $248,338 | -46.2% | 179 | -27 | $1,387 | $7,504,922 | 6 | Roadshow Films | false | false |
| 11 | 7 | G.I. Joe: The Rise of Cobra | $229,214 | -50.2% | 151 | -48 | $1,517 | $6,551,281 | 5 | Paramount Pictures International | false | false |
| 12 | 8 | Fighting | $215,416 | -46.7% | 102 | - | $2,111 | $742,188 | 2 | Roadshow Films | false | false |
| 13 | 9 | Harry Potter and the Half-Blood Prince | $191,269 | -49.7% | 132 | -82 | $1,449 | $33,975,717 | 8 | Warner Bros. | false | false |
| 14 | 12 | The September Issue | $126,306 | -17% | 25 | +9 | $5,052 | $596,678 | 3 | Madman Entertainment | false | false |
| 15 | 10 | Coraline | $115,506 | -68.5% | 121 | -56 | $954 | $3,553,861 | 6 | Trafalgar Releasing | false | false |
| 16 | 13 | Ponyo | $88,457 | -20.5% | 38 | +2 | $2,327 | $232,805 | 2 | Madman Entertainment | false | false |
| 17 | 11 | Public Enemies | $76,062 | -60.4% | 74 | -106 | $1,027 | $7,484,127 | 6 | Universal Pictures International (UPI) | false | false |
| 18 | 14 | Balibo | $72,250 | -34.3% | 35 | +2 | $2,064 | $677,699 | 4 | Paramount Pictures International | false | false |
| 19 | 16 | Beautiful Kate | $56,889 | -39.4% | 27 | -2 | $2,107 | $1,065,656 | 6 | Roadshow Films | false | false |
| 20 | 19 | Taking Woodstock | $46,845 | -39.5% | 43 | -1 | $1,089 | $169,345 | 2 | Universal Pictures International (UPI) | false | false |
| 21 | - | Dinosaurs Alive | $16,983 | - | 1 | - | $16,983 | $18,144 | 2 | IMAX | false | false |
| 22 | - | Tidal Wave | $16,869 | - | 1 | - | $16,869 | $16,869 | 1 | Madman Entertainment | true | false |
| 23 | - | The Girlfriend Experience | $13,767 | - | 8 | - | $1,720 | $13,767 | 1 | Icon Film Distribution | true | false |
| 24 | - | Blessed | $7,138 | - | 14 | - | $509 | $7,138 | - | Icon Film Distribution | - | false |
| 25 | - | Kisaan | $1,569 | - | 2 | - | $784 | $1,569 | 1 | N/A | true | false |
| 26 | - | Shorts | $969 | - | 5 | - | $193 | $969 | - | Warner Bros. | - | false |
