| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | District 9 | $270,792 | - | 81 | - | $3,343 | $270,792 | 1 | Ster-Kinekor Pictures | true | false |
| 2 | 1 | G.I. Joe: The Rise of Cobra | $112,803 | -24.5% | 73 | -1 | $1,545 | $756,811 | 3 | United International Pictures | false | false |
| 3 | 2 | G-Force | $94,558 | -14.5% | 64 | - | $1,477 | $926,051 | 5 | Ster-Kinekor Pictures | false | false |
| 4 | 4 | The Proposal | $76,750 | -8.2% | 63 | -1 | $1,218 | $2,195,118 | 8 | Ster-Kinekor Pictures | false | false |
| 5 | 3 | My Sister's Keeper | $71,183 | -19% | 46 | +1 | $1,547 | $449,551 | 3 | NuMetro Distribution | false | false |
| 6 | 6 | The Hangover | $30,701 | -20.8% | 47 | -5 | $653 | $1,850,893 | 11 | NuMetro Distribution | false | false |
| 7 | 5 | Year One | $30,493 | -26.9% | 21 | +1 | $1,452 | $92,109 | 2 | Ster-Kinekor Pictures | false | false |
| 8 | - | Coco Before Chanel | $30,200 | - | 9 | - | $3,355 | $30,200 | 1 | NuMetro Distribution | true | false |
| 9 | 7 | Ice Age: Dawn of the Dinosaurs | $26,293 | -16.1% | 47 | -6 | $559 | $3,318,756 | 9 | NuMetro Distribution | false | false |
| 10 | 8 | Fired Up! | $25,736 | -9.5% | 31 | -4 | $830 | $232,490 | 4 | Ster-Kinekor Pictures | false | false |
| 11 | 10 | Orphan | $20,399 | -23% | 25 | - | $815 | $59,728 | 2 | NuMetro Distribution | false | false |
| 12 | 12 | My Life in Ruins | $19,862 | -14.6% | 31 | -2 | $640 | $313,664 | 5 | Ster-Kinekor Pictures | false | false |
| 13 | 11 | Not Easily Broken | $18,762 | -21.3% | 20 | - | $938 | $54,389 | 2 | NuMetro Distribution | false | false |
| 14 | 9 | Harry Potter and the Half-Blood Prince | $18,212 | -34.4% | 39 | -14 | $466 | $1,714,506 | 7 | NuMetro Distribution | false | false |
| 15 | 15 | Fighting | $8,873 | +31.7% | 21 | -1 | $422 | $231,609 | 6 | United International Pictures | false | false |
| 16 | 14 | Disgrace | $5,829 | -40.5% | 10 | - | $582 | $41,952 | 3 | United International Pictures | false | false |
| 17 | 13 | Izulu lami | $4,558 | -59.1% | 17 | -6 | $268 | $22,371 | 2 | Ster-Kinekor Pictures | false | false |
| 18 | 22 | Obsessed | $3,819 | +20.1% | 8 | - | $477 | $331,736 | 11 | Ster-Kinekor Pictures | false | false |
| 19 | 16 | A Summer in Genoa | $3,816 | -39.3% | 8 | - | $477 | $48,805 | 4 | United International Pictures | false | false |
| 20 | - | I Love You, Beth Cooper | $3,813 | - | 8 | - | $476 | $63,420 | 6 | NuMetro Distribution | false | false |
| 21 | 20 | Transformers: Revenge of the Fallen | $3,795 | -16.2% | 6 | -3 | $632 | $2,377,411 | 10 | United International Pictures | false | false |
| 22 | 19 | Knowing | $3,055 | -33.8% | 4 | -6 | $763 | $836,731 | 9 | United International Pictures | false | false |
| 23 | 23 | Brüno | $186 | -88.8% | 2 | -4 | $93 | $410,927 | 8 | United International Pictures | false | false |
| 24 | - | Heaven on Earth | $27 | - | 1 | - | $27 | $17,501 | 5 | Ster-Kinekor Pictures | false | false |
