| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Hangover | $795,984 | -22% | 391 | -7 | $2,035 | $4,967,532 | 3 | Warner Bros. | false | false |
| 2 | - | Aliens in the Attic | $545,562 | - | 300 | - | $1,818 | $545,562 | 1 | 20th Century Fox International | true | false |
| 3 | 2 | Drag Me to Hell | $512,225 | -27.8% | 307 | -11 | $1,668 | $1,626,267 | 2 | Universal Pictures International (UPI) | false | false |
| 4 | - | Recién Cazado | $447,921 | - | 200 | - | $2,239 | $447,921 | 1 | Warner Bros. | true | false |
| 5 | 5 | The Time Traveler's Wife | $362,048 | -28% | 258 | -4 | $1,403 | $1,183,246 | 2 | Gussi Films | false | false |
| 6 | 3 | G.I. Joe: The Rise of Cobra | $344,249 | -44.8% | 395 | -52 | $871 | $7,017,958 | 4 | Paramount Pictures International | false | false |
| 7 | 4 | G-Force | $313,801 | -38.2% | 398 | -162 | $788 | $9,764,012 | 5 | Walt Disney Pictures | false | false |
| 8 | - | Defiance | $247,627 | - | 178 | - | $1,391 | $247,627 | 1 | N/A | true | false |
| 9 | 6 | Land of the Lost | $218,633 | -40.2% | 233 | -23 | $938 | $1,715,673 | 3 | Universal Pictures International (UPI) | false | false |
| 10 | 7 | Imagine That | $161,108 | -50.6% | 270 | -3 | $596 | $618,053 | 2 | Paramount Pictures International | false | false |
| 11 | 11 | The Uninvited | $126,485 | +13.5% | 130 | +1 | $972 | $2,334,785 | 6 | Paramount Pictures International | false | false |
| 12 | 8 | Walking Vengeance | $123,445 | -53.7% | 264 | -1 | $467 | $578,352 | 2 | Videocine | false | false |
| 13 | 10 | Ice Age: Dawn of the Dinosaurs | $104,637 | -45.6% | 173 | -103 | $604 | $41,000,054 | 9 | 20th Century Fox International | false | false |
| 14 | 13 | My Sister's Keeper | $98,376 | -5.9% | 92 | -3 | $1,069 | $3,620,148 | 10 | Warner Bros. | false | false |
| 15 | 9 | Terminator Salvation | $81,185 | -59.7% | 181 | -213 | $448 | $7,407,792 | 5 | Sony Pictures Releasing | false | false |
| 16 | 12 | Shorts | $70,151 | -34% | 109 | -38 | $643 | $1,308,300 | 4 | Warner Bros. | false | false |
| 17 | 16 | El ratón Pérez 2 | $67,819 | +52.8% | 119 | -25 | $569 | $367,348 | 3 | Walt Disney Pictures | false | false |
| 18 | - | El Estudiante | $67,702 | - | 40 | - | $1,692 | $336,190 | 3 | N/A | false | false |
| 19 | 21 | How to Lose Friends & Alienate People | $53,793 | +276.7% | 62 | +33 | $867 | $389,716 | 6 | N/A | false | false |
| 20 | 15 | Crossing Over | $50,751 | -29.5% | 81 | -23 | $626 | $1,254,604 | 6 | N/A | false | false |
| 21 | 14 | Harry Potter and the Half-Blood Prince | $44,250 | -54.5% | 74 | -84 | $597 | $22,065,438 | 7 | Warner Bros. | false | false |
