| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Harry Potter and the Half-Blood Prince | $1,084,972 | - | 163 | - | $6,656 | $1,952,270 | 1 | Warner Bros. | true | false |
| 2 | 1 | Inglourious Basterds | $395,513 | -29.4% | 66 | -14 | $5,992 | $1,226,272 | 2 | United International Pictures | false | false |
| 3 | 3 | Ice Age: Dawn of the Dinosaurs | $75,960 | -17.1% | 54 | +15 | $1,406 | $3,833,007 | 9 | 20th Century Fox International | false | false |
| 4 | 2 | I Hate Valentine's Day | $67,773 | -45.3% | 22 | -4 | $3,080 | $250,005 | 2 | Odeon | false | false |
| 5 | 4 | The Hangover | $60,890 | -33.5% | 29 | -10 | $2,099 | $2,617,839 | 7 | Warner Bros. | false | false |
| 6 | - | Five Minutes of Heaven | $23,579 | - | 2 | - | $11,789 | $23,579 | 1 | Rosebud | true | false |
| 7 | 5 | The Taking of Pelham 123 | $17,272 | -34.4% | 12 | +4 | $1,439 | $492,606 | 6 | Sony Pictures Releasing | false | false |
| 8 | 6 | Transporter 3 | $17,214 | -32.1% | 10 | -6 | $1,721 | $308,104 | 5 | Audio Visual Enterprises | false | false |
| 9 | 10 | Mid-August Lunch | $14,355 | +2.8% | 2 | - | $7,177 | $70,794 | 3 | N/A | false | false |
| 10 | 7 | The Private Lives of Pippa Lee | $8,740 | -43.5% | 7 | -2 | $1,248 | $314,584 | 5 | Odeon | false | false |
| 11 | 11 | Brüno | $1,038 | -76.2% | 2 | -1 | $519 | $507,039 | 8 | Sony Pictures Releasing | false | false |
