| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Inglourious Basterds | $1,787,553 | -30% | 266 | - | $6,720 | $5,487,087 | 2 | Universal Pictures International (UPI) | false | false |
| 2 | - | The Taking of Pelham 123 | $1,438,738 | - | 246 | - | $5,848 | $1,444,678 | 1 | Sony Pictures Releasing | true | false |
| 3 | 2 | The Ugly Truth | $783,282 | -34.9% | 259 | -8 | $3,024 | $8,908,293 | 4 | Sony Pictures Releasing | false | false |
| 4 | - | The Young Victoria | $730,892 | - | 124 | - | $5,894 | $730,892 | 1 | Roadshow Films | true | false |
| 5 | 3 | District 9 | $717,382 | -39.5% | 172 | -6 | $4,170 | $4,880,371 | 3 | Sony Pictures Releasing | false | false |
| 6 | 5 | My Sister's Keeper | $461,509 | -28.9% | 206 | -4 | $2,240 | $7,008,139 | 5 | Roadshow Films | false | false |
| 7 | 4 | G.I. Joe: The Rise of Cobra | $460,190 | -37% | 199 | -1 | $2,312 | $6,133,195 | 4 | Paramount Pictures International | false | false |
| 8 | - | Fighting | $404,113 | - | 102 | - | $3,961 | $404,113 | 1 | Roadshow Films | true | false |
| 9 | 6 | Harry Potter and the Half-Blood Prince | $380,054 | -28.4% | 214 | -59 | $1,775 | $33,302,812 | 7 | Warner Bros. | false | false |
| 10 | 7 | Coraline | $366,797 | -28.9% | 177 | -19 | $2,072 | $3,343,824 | 5 | Trafalgar Releasing | false | false |
| 11 | 8 | Public Enemies | $192,187 | -53.9% | 180 | -78 | $1,067 | $7,257,760 | 5 | Universal Pictures International (UPI) | false | false |
| 12 | 11 | The September Issue | $152,179 | +4.7% | 16 | +4 | $9,511 | $399,876 | 2 | Madman Entertainment | false | false |
| 13 | - | Ponyo | $111,216 | - | 36 | - | $3,089 | $113,231 | 1 | Madman Entertainment | true | false |
| 14 | 13 | Balibo | $110,053 | -10.6% | 33 | +8 | $3,334 | $547,221 | 3 | Paramount Pictures International | false | false |
| 15 | 9 | Dance Flick | $94,045 | -52.9% | 99 | -1 | $949 | $360,384 | 2 | Paramount Pictures International | false | false |
| 16 | 12 | Beautiful Kate | $93,894 | -30.4% | 29 | - | $3,237 | $960,978 | 5 | Roadshow Films | false | false |
| 17 | - | Bandslam | $87,553 | - | 156 | -36 | $561 | $642,090 | 3 | Hoyts Distribution | false | false |
| 18 | 10 | Orphan | $78,366 | -53.8% | 82 | -29 | $955 | $741,241 | 3 | Warner Bros. | false | false |
| 19 | - | Taking Woodstock | $77,391 | - | 44 | - | $1,758 | $85,796 | 1 | Universal Pictures International (UPI) | true | false |
| 20 | 14 | The Hangover | $38,230 | -50.6% | 43 | -28 | $889 | $17,934,378 | 12 | Warner Bros. | false | false |
| 21 | - | Apni Boli Apna Des | $5,168 | - | 4 | - | $1,292 | $5,168 | 1 | Mind Blowing Films | true | false |
