| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Harry Potter and the Half-Blood Prince | $459,125 | -32.5% | 193 | -10 | $2,378 | $14,600,659 | 6 | Warner Bros. | false | false |
| 2 | - | The Taking of Pelham 123 | $357,274 | - | 70 | - | $5,103 | $413,061 | 1 | Sony Pictures Releasing | true | false |
| 3 | 3 | Ice Age: Dawn of the Dinosaurs | $236,104 | -37.5% | 196 | -20 | $1,204 | $11,622,876 | 8 | 20th Century Fox International | false | false |
| 4 | 2 | G.I. Joe: The Rise of Cobra | $223,733 | -50.8% | 82 | +1 | $2,728 | $871,340 | 2 | United International Pictures | false | false |
| 5 | 4 | Public Enemies | $169,655 | -33.3% | 80 | - | $2,120 | $1,986,295 | 4 | Universal Pictures International (UPI) | false | false |
| 6 | 5 | G-Force | $164,993 | -30.1% | 109 | -5 | $1,513 | $1,762,333 | 4 | Walt Disney Pictures | false | false |
| 7 | 6 | The Girl with the Dragon Tattoo | $113,480 | -21.4% | 38 | +3 | $2,986 | $614,553 | 3 | Benelux Film Distributors | false | false |
| 8 | 8 | The Hangover | $105,345 | -6.4% | 57 | -7 | $1,848 | $4,655,992 | 11 | Warner Bros. | false | false |
| 9 | 7 | The Proposal | $97,856 | -19.5% | 67 | -7 | $1,460 | $3,910,973 | 10 | Walt Disney Pictures | false | false |
| 10 | - | Hannah Montana: The Movie | $78,514 | - | 30 | - | $2,617 | $113,039 | 1 | Walt Disney Pictures | true | false |
| 11 | 9 | A Perfect Getaway | $63,397 | -39.3% | 52 | -2 | $1,219 | $477,393 | 3 | A-Film Distribution | false | false |
| 12 | 10 | Het geheim van Mega Mindy | $53,537 | -43.4% | 106 | -1 | $505 | $1,992,414 | 7 | Independent Films | false | false |
| 13 | - | Lilly the Witch: The Dragon and the Magic Book | $42,728 | - | 50 | - | $854 | $45,943 | 1 | RCV Film Distribution | true | false |
| 14 | 13 | Ghosts of Girlfriends Past | $37,940 | -40.2% | 39 | -11 | $972 | $966,774 | 5 | RCV Film Distribution | false | false |
| 15 | 11 | Luke and Lucy: The Texas Rangers | $35,520 | -46.8% | 87 | -1 | $408 | $674,350 | 5 | RCV Film Distribution | false | false |
| 16 | 12 | The Indian | $33,412 | -49% | 71 | +1 | $470 | $218,663 | 2 | A-Film Distribution | false | false |
| 17 | - | Mid-August Lunch | $32,314 | - | 11 | - | $2,937 | $54,997 | 1 | Cinemien | true | false |
| 18 | 14 | Brüno | $21,841 | -51.2% | 33 | -26 | $661 | $2,940,743 | 7 | Universal Pictures International (UPI) | false | false |
| 19 | 15 | Away We Go | $20,638 | -28% | 16 | - | $1,289 | $68,841 | 2 | A-Film Distribution | false | false |
| 20 | - | Fifty Dead Men Walking | $11,535 | - | 10 | - | $1,153 | $16,077 | 1 | - | true | false |
| 21 | 17 | Angels & Demons | $11,282 | -37% | 18 | -3 | $626 | $7,760,800 | 15 | Sony Pictures Releasing | false | false |
| 22 | - | Machan | $1,300 | - | 4 | - | $325 | $1,300 | 1 | Moonlight Films | true | false |
| 23 | - | Blind Pig Who Wants to Fly | $344 | - | 1 | - | $344 | $344 | 1 | Filmmuseum Distributie | true | false |
