| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Up | $79,912 | - | 12 | - | $6,659 | $102,793 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | - | District 9 | $27,938 | - | 5 | - | $5,587 | $27,938 | 2 | Sony Pictures Releasing | false | false |
| 3 | 1 | Ice Age: Dawn of the Dinosaurs | $13,743 | -55.9% | 7 | -3 | $1,963 | $1,313,914 | 8 | Universal Pictures International (UPI) | false | false |
| 4 | 3 | My Sister's Keeper | $8,864 | -26.8% | 4 | - | $2,216 | $67,538 | 3 | Garsu Pasaulio Irasai | false | false |
| 5 | 2 | G.I. Joe: The Rise of Cobra | $6,293 | -56.7% | 4 | - | $1,573 | $31,882 | 2 | Universal Pictures International (UPI) | false | false |
| 6 | 5 | Harry Potter and the Half-Blood Prince | $4,764 | -41% | 5 | -3 | $952 | $292,589 | 5 | Garsu Pasaulio Irasai | false | false |
| 7 | - | Year One | $4,574 | - | 5 | - | $914 | $64,368 | - | Sony Pictures Releasing | - | false |
| 8 | 6 | The Taking of Pelham 123 | $3,016 | -52% | 3 | -4 | $1,005 | $65,278 | 4 | Sony Pictures Releasing | false | false |
| 9 | 7 | Brüno | $2,987 | -45.6% | 5 | -2 | $597 | $145,158 | 5 | ACME | false | false |
| 10 | 8 | Diary of a Nymphomaniac | $2,776 | -35.5% | 2 | - | $1,388 | $20,788 | 3 | ACME | false | false |
| 11 | - | Let the Right One In | $1,046 | - | 1 | - | $1,046 | $4,391 | 1 | Universal Pictures International (UPI) | true | false |
| 12 | 10 | Hannah Montana: The Movie | $1,032 | -51.4% | 3 | - | $344 | $26,686 | 4 | Universal Pictures International (UPI) | false | false |
| 13 | 13 | Easy Virtue | $886 | -30.2% | 2 | - | $443 | $17,121 | 4 | ACME | false | false |
| 14 | 12 | The Last House on the Left | $798 | -53.5% | 2 | -1 | $399 | $26,094 | 5 | Universal Pictures International (UPI) | false | false |
| 15 | 11 | The Hangover | $665 | -65.7% | 1 | -4 | $665 | $293,723 | 11 | Garsu Pasaulio Irasai | false | false |
| 16 | 14 | Public Enemies | $643 | -46% | 2 | -3 | $321 | $89,843 | 7 | Universal Pictures International (UPI) | false | false |
| 17 | 9 | Fly Me to the Moon 3D | $443 | -89.4% | 2 | -1 | $221 | $150,284 | 31 | Universal Pictures International (UPI) | false | false |
| 18 | 15 | Gomorrah | $104 | -88.6% | 1 | -1 | $104 | $23,978 | 6 | Universal Pictures International (UPI) | false | false |
