| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Haunting in Connecticut | $458,508 | - | 198 | - | $2,315 | $458,508 | 1 | Lucky Red | true | false |
| 2 | - | S. Darko | $351,906 | - | 212 | - | $1,659 | $351,906 | 1 | N/A | true | false |
| 3 | 1 | Sex Drive | $303,524 | -15.3% | 151 | - | $2,010 | $1,001,051 | 2 | Eagle Pictures | false | false |
| 4 | 2 | Harry Potter and the Half-Blood Prince | $227,062 | -13.3% | 359 | -118 | $632 | $25,625,362 | 6 | Warner Bros. | false | false |
| 5 | 3 | Aliens in the Attic | $208,048 | -19.5% | 210 | +5 | $990 | $700,798 | 2 | 20th Century Fox International | false | false |
| 6 | 4 | The Hangover | $120,949 | +11.3% | 93 | -15 | $1,300 | $5,413,795 | 10 | Warner Bros. | false | false |
| 7 | - | Shorts | $112,389 | - | 141 | - | $797 | $112,389 | 1 | Warner Bros. | true | false |
| 8 | 5 | Ghosts of Girlfriends Past | $65,200 | -1.5% | 57 | -24 | $1,143 | $2,747,681 | 8 | Warner Bros. | false | false |
| 9 | 7 | Coraline | $43,178 | +25.9% | 47 | +2 | $918 | $4,957,811 | 10 | United International Pictures | false | false |
| 10 | - | I Love You, Man | $42,059 | - | 49 | - | $858 | $42,059 | 1 | United International Pictures | true | false |
| 11 | 6 | Transformers: Revenge of the Fallen | $31,911 | -47.7% | 50 | -46 | $638 | $11,685,751 | 9 | United International Pictures | false | false |
| 12 | 13 | The Boat That Rocked | $28,421 | +59.5% | 31 | +9 | $916 | $1,117,126 | 11 | United International Pictures | false | false |
| 13 | 9 | The Girl with the Dragon Tattoo | $26,247 | +6.6% | 28 | -12 | $937 | $5,255,754 | 13 | BIM Distribuzione | false | false |
| 14 | 10 | Journey to the Center of the Earth | $21,980 | +4.5% | 21 | -1 | $1,046 | $11,724,131 | 32 | 01 Distribution | false | false |
| 15 | 15 | My Bloody Valentine | $19,282 | +58.2% | 13 | -1 | $1,483 | $8,725,914 | 16 | Medusa Distribuzione | false | false |
| 16 | 12 | Angels & Demons | $18,719 | -4.1% | 7 | -7 | $2,674 | $26,775,811 | 15 | Sony Pictures Releasing | false | false |
| 17 | 16 | Gran Torino | $18,574 | +55.1% | 22 | +5 | $844 | $12,993,866 | 24 | Warner Bros. | false | false |
| 18 | 8 | Outlander | $14,244 | -44.9% | 18 | -20 | $791 | $1,662,491 | 8 | Eagle Pictures | false | false |
| 19 | - | Different from Whom | $9,048 | - | 18 | - | $502 | $4,602,897 | 23 | United International Pictures | false | false |
| 20 | 24 | Ultimate Heist | $6,931 | +11.5% | 2 | - | $3,465 | $53,967 | 4 | Medusa Distribuzione | false | false |
| 21 | 20 | Imagine That | $6,719 | -25.1% | 7 | -4 | $959 | $86,182 | 4 | United International Pictures | false | false |
| 22 | 19 | Night at the Museum: Battle of the Smithsonian | $6,677 | -28.3% | 13 | -2 | $513 | $9,988,389 | 14 | 20th Century Fox International | false | false |
| 23 | 23 | State of Play | $6,673 | -7.7% | 7 | -4 | $953 | $3,559,324 | 17 | United International Pictures | false | false |
| 24 | 18 | Slumdog Millionaire | $5,777 | -39.7% | 9 | -12 | $641 | $8,901,023 | 38 | Lucky Red | false | false |
| 25 | - | Coco Before Chanel | $5,377 | - | 9 | - | $597 | $1,792,873 | 13 | Warner Bros. | false | false |
| 26 | - | The Friends at the Margherita Cafe | $4,628 | - | 6 | - | $771 | $4,326,733 | 21 | 01 Distribution | false | false |
| 27 | 32 | The Nightmare Before Christmas 2008 3D Release | $4,590 | +15.9% | 9 | - | $510 | $144,321 | 91 | Walt Disney Pictures | false | false |
| 28 | - | Easy Virtue | $4,216 | - | 7 | - | $602 | $3,590,951 | 33 | Eagle Pictures | false | false |
| 29 | - | Vincere | $4,193 | - | 9 | - | $465 | $2,991,766 | 14 | 01 Distribution | false | false |
| 30 | 29 | Bolt | $3,975 | -8.9% | 10 | -2 | $397 | $7,609,070 | 39 | Walt Disney Pictures | false | false |
| 31 | - | The Curious Case of Benjamin Button | $3,925 | - | 7 | - | $560 | $15,750,900 | 28 | Warner Bros. | false | false |
| 32 | - | Two Lovers | $3,790 | - | 4 | - | $947 | $1,339,026 | 22 | BIM Distribuzione | false | false |
| 33 | 30 | Monsters vs. Aliens | $3,688 | -13.1% | 8 | -1 | $461 | $10,546,331 | 21 | United International Pictures | false | false |
| 34 | 22 | Killshot | $3,685 | -53.4% | 6 | -4 | $614 | $75,474 | 4 | 01 Distribution | false | false |
| 35 | 33 | The Reader | $3,518 | -10.2% | 7 | -1 | $502 | $3,645,386 | 27 | 01 Distribution | false | false |
| 36 | 31 | Obsessed | $1,412 | -65.6% | 3 | -3 | $470 | $83,546 | 6 | Sony Pictures Releasing | false | false |
