| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Inglourious Basterds | $2,551,864 | - | 266 | - | $9,593 | $2,628,541 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | 1 | The Ugly Truth | $1,202,872 | -36.8% | 267 | -17 | $4,505 | $7,666,356 | 3 | Sony Pictures Releasing | false | false |
| 3 | 2 | District 9 | $1,185,192 | -34.4% | 178 | - | $6,658 | $3,717,495 | 2 | Sony Pictures Releasing | false | false |
| 4 | 3 | G.I. Joe: The Rise of Cobra | $730,320 | -41.6% | 200 | -23 | $3,651 | $5,436,139 | 3 | Paramount Pictures International | false | false |
| 5 | 5 | My Sister's Keeper | $649,263 | -25.1% | 210 | - | $3,091 | $6,264,055 | 4 | Roadshow Films | false | false |
| 6 | 4 | Harry Potter and the Half-Blood Prince | $531,029 | -40.1% | 273 | -46 | $1,945 | $32,543,452 | 6 | Warner Bros. | false | false |
| 7 | 7 | Coraline | $515,959 | -31.4% | 196 | -16 | $2,632 | $2,864,556 | 4 | Trafalgar Releasing | false | false |
| 8 | 6 | Public Enemies | $416,718 | -48% | 258 | - | $1,615 | $6,869,356 | 4 | Universal Pictures International (UPI) | false | false |
| 9 | - | Dance Flick | $199,690 | - | 100 | - | $1,996 | $199,690 | 1 | Paramount Pictures International | true | false |
| 10 | 8 | Orphan | $169,792 | -43.9% | 111 | +1 | $1,529 | $596,644 | 2 | Warner Bros. | false | false |
| 11 | - | The September Issue | $145,406 | - | 12 | - | $12,117 | $167,823 | 1 | Madman Entertainment | true | false |
| 12 | 10 | Beautiful Kate | $134,971 | -32% | 29 | - | $4,654 | $807,453 | 4 | Roadshow Films | false | false |
| 13 | 11 | Balibo | $123,064 | -28.3% | 25 | +2 | $4,922 | $392,592 | 2 | Paramount Pictures International | false | false |
| 14 | 12 | The Hangover | $77,400 | -50.3% | 71 | -35 | $1,090 | $17,743,661 | 11 | Warner Bros. | false | false |
| 15 | 13 | Ice Age: Dawn of the Dinosaurs | $75,785 | -51.4% | 100 | -61 | $757 | $24,725,499 | 8 | 20th Century Fox International | false | false |
| 16 | - | Subdivision | $72,297 | - | 66 | - | $1,095 | $83,630 | 1 | Walt Disney Pictures | true | false |
| 17 | - | Adam | $55,722 | - | 25 | - | $2,228 | $55,917 | - | 20th Century Fox International | - | false |
| 18 | 16 | Coco Before Chanel | $52,405 | -30.7% | 37 | -2 | $1,416 | $2,108,680 | 9 | Roadshow Films | false | false |
| 19 | 14 | Kaminey | $41,134 | -62% | 12 | - | $3,427 | $188,107 | 2 | Mind Blowing Films | false | false |
| 20 | 15 | Transformers: Revenge of the Fallen | $40,861 | -51% | 37 | -29 | $1,104 | $33,554,033 | 9 | Paramount Pictures International | false | false |
| 21 | 19 | My Life in Ruins | $33,571 | -14.3% | 61 | +9 | $550 | $2,273,373 | 6 | 20th Century Fox International | false | false |
| 22 | 17 | Chéri | $32,250 | -42.2% | 62 | +16 | $520 | $815,029 | 5 | Icon Film Distribution | false | false |
| 23 | - | Eden Is West | $28,331 | - | 11 | - | $2,575 | $28,331 | 1 | Jump Street Films | true | false |
| 24 | - | The Cove | $17,157 | - | 20 | - | $857 | $17,157 | 1 | Gil Scrine Films | true | false |
| 25 | - | Spread | $16,390 | - | 14 | - | $1,170 | $16,390 | 1 | N/A | true | false |
| 26 | 20 | The Proposal | $14,577 | -60.5% | 3 | -33 | $4,859 | $13,971,668 | 10 | Walt Disney Pictures | false | false |
| 27 | 18 | Drag Me to Hell | $10,329 | -77.2% | 17 | -33 | $607 | $2,197,202 | 5 | Roadshow Films | false | false |
| 28 | - | Metallic Attraction: Kungfu Cyborg | $4,397 | - | 7 | - | $628 | $4,397 | 1 | Arkles Entertainment | true | false |
| 29 | - | Mummies: Secrets of the Pharaohs | $3,547 | - | 1 | - | $3,547 | $3,547 | 1 | IMAX | true | false |
| 30 | - | Dinosaurs Alive | $1,161 | - | 1 | - | $1,161 | $1,161 | - | IMAX | - | false |
| 31 | 23 | Every Little Step | $834 | -55.6% | 1 | -2 | $834 | $99,813 | 8 | Sony Pictures Releasing | false | false |
