| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Sex Drive | $358,412 | - | 151 | - | $2,373 | $358,412 | 1 | Eagle Pictures | true | false |
| 2 | 1 | Harry Potter and the Half-Blood Prince | $262,027 | -56.3% | 477 | -130 | $549 | $24,905,096 | 5 | Warner Bros. | false | false |
| 3 | - | Aliens in the Attic | $258,452 | - | 205 | - | $1,260 | $258,452 | 1 | 20th Century Fox International | true | false |
| 4 | 2 | The Hangover | $108,645 | -42.2% | 108 | -26 | $1,005 | $5,132,641 | 9 | Warner Bros. | false | false |
| 5 | 3 | Ghosts of Girlfriends Past | $66,209 | -54.8% | 81 | -42 | $817 | $2,589,932 | 7 | Warner Bros. | false | false |
| 6 | 4 | Transformers: Revenge of the Fallen | $60,969 | -48.1% | 96 | -52 | $635 | $11,495,229 | 8 | United International Pictures | false | false |
| 7 | 6 | Coraline | $34,286 | -41.4% | 45 | -20 | $761 | $4,832,387 | 9 | United International Pictures | false | false |
| 8 | 5 | Outlander | $25,869 | -57.5% | 38 | -38 | $680 | $1,613,460 | 7 | Eagle Pictures | false | false |
| 9 | 8 | The Girl with the Dragon Tattoo | $24,632 | -37.1% | 40 | -4 | $615 | $5,155,438 | 12 | BIM Distribuzione | false | false |
| 10 | 7 | Journey to the Center of the Earth | $21,040 | -48.7% | 22 | -12 | $956 | $11,583,062 | 31 | 01 Distribution | false | false |
| 11 | 13 | I Know Who Killed Me | $20,352 | -19% | 18 | -3 | $1,130 | $152,633 | 50 | Moviemax | false | false |
| 12 | 12 | Angels & Demons | $19,515 | -33% | 14 | - | $1,393 | $26,182,977 | 14 | Sony Pictures Releasing | false | false |
| 13 | 9 | The Boat That Rocked | $17,822 | -46.8% | 22 | -13 | $810 | $1,073,233 | 10 | United International Pictures | false | false |
| 14 | 10 | Un'estate ai Caraibi | $15,078 | -50.2% | 31 | -18 | $486 | $5,311,857 | 10 | Medusa Distribuzione | false | false |
| 15 | 15 | My Bloody Valentine | $12,186 | -34.8% | 14 | -9 | $870 | $8,749,598 | 15 | Medusa Distribuzione | false | false |
| 16 | 14 | Gran Torino | $11,975 | -44.5% | 17 | -13 | $704 | $13,046,063 | 23 | Warner Bros. | false | false |
| 17 | 11 | Flash of Genius | $9,813 | -67% | 32 | -20 | $306 | $60,891 | 2 | United International Pictures | false | false |
| 18 | - | Slumdog Millionaire | $9,586 | - | 21 | - | $456 | $8,882,863 | 37 | Lucky Red | false | false |
| 19 | 24 | Night at the Museum: Battle of the Smithsonian | $9,308 | +30.8% | 15 | +1 | $620 | $9,968,396 | 13 | 20th Century Fox International | false | false |
| 20 | 16 | Imagine That | $8,967 | -39.8% | 11 | -1 | $815 | $71,572 | 3 | United International Pictures | false | false |
| 21 | - | Mid-August Lunch | $7,956 | - | 7 | - | $1,136 | $3,083,179 | 50 | Fandango | false | false |
| 22 | 17 | Killshot | $7,905 | -43.1% | 10 | - | $790 | $65,013 | 3 | 01 Distribution | false | false |
| 23 | 21 | State of Play | $7,231 | -24.8% | 11 | +2 | $657 | $3,547,170 | 16 | United International Pictures | false | false |
| 24 | 18 | Ultimate Heist | $6,215 | -45.7% | 2 | -1 | $3,107 | $43,924 | 3 | Medusa Distribuzione | false | false |
| 25 | 19 | Towelhead | $4,500 | -55.9% | 12 | -4 | $375 | $103,106 | 5 | N/A | false | false |
| 26 | 20 | My Best Friend's Girl | $4,453 | -54% | 10 | -6 | $445 | $1,537,633 | 9 | Eagle Pictures | false | false |
| 27 | - | Brideshead Revisited | $4,451 | - | 5 | - | $890 | $71,921 | 8 | Walt Disney Pictures | false | false |
| 28 | - | The Man Who Loves | $4,432 | - | 22 | - | $201 | $1,997,433 | 43 | Medusa Distribuzione | false | false |
| 29 | - | Bolt | $4,361 | - | 12 | - | $363 | $7,599,176 | 38 | Walt Disney Pictures | false | false |
| 30 | - | Monsters vs. Aliens | $4,243 | - | 9 | - | $471 | $10,537,748 | 20 | United International Pictures | false | false |
| 31 | 28 | Obsessed | $4,105 | -37.2% | 6 | - | $684 | $79,067 | 5 | Sony Pictures Releasing | false | false |
| 32 | - | The Nightmare Before Christmas 2008 3D Release | $3,959 | - | 9 | - | $439 | $133,424 | 90 | Walt Disney Pictures | false | false |
| 33 | - | The Reader | $3,919 | - | 8 | - | $489 | $3,638,551 | 26 | 01 Distribution | false | false |
| 34 | - | Questione di cuore | $3,835 | - | 11 | - | $348 | $3,919,677 | 18 | 01 Distribution | false | false |
| 35 | - | Chef's Special 2009 Re-release | $3,256 | - | 5 | - | $651 | $514,692 | 17 | N/A | false | false |
