| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Time Traveler's Wife | $2,332,285 | - | 425 | - | $5,487 | $2,332,285 | 1 | Entertainment Film Distributors | true | false |
| 2 | - | Aliens in the Attic | $2,188,813 | - | 435 | - | $5,031 | $2,188,813 | 2 | 20th Century Fox International | false | false |
| 3 | 4 | G-Force | $1,557,546 | -23.7% | 468 | +42 | $3,328 | $14,719,868 | 3 | Walt Disney Pictures | false | false |
| 4 | 3 | Harry Potter and the Half-Blood Prince | $1,542,492 | -31.5% | 464 | -71 | $3,324 | $77,338,887 | 5 | Warner Bros. | false | false |
| 5 | 2 | G.I. Joe: The Rise of Cobra | $1,368,264 | -52% | 442 | - | $3,095 | $6,394,913 | 2 | Paramount Pictures International | false | false |
| 6 | 1 | The Ugly Truth | $1,338,498 | -59.4% | 398 | -2 | $3,363 | $6,749,307 | 2 | Sony Pictures Releasing | false | false |
| 7 | - | Bandslam | $1,040,114 | - | 377 | - | $2,758 | $1,040,114 | 1 | Entertainment One | true | false |
| 8 | 7 | Ice Age: Dawn of the Dinosaurs | $841,599 | -17.6% | 417 | -63 | $2,018 | $53,605,118 | 7 | 20th Century Fox International | false | false |
| 9 | 5 | The Proposal | $737,042 | -41.5% | 380 | -61 | $1,939 | $17,144,958 | 2 | Walt Disney Pictures | false | false |
| 10 | - | A Perfect Getaway | $692,414 | - | 214 | - | $3,235 | $692,414 | - | Momentum Pictures | - | false |
| 11 | 8 | Orphan | $627,053 | -34.1% | 278 | -7 | $2,255 | $2,604,506 | 2 | Optimum Releasing | false | false |
| 12 | 6 | The Taking of Pelham 123 | $536,198 | -51.4% | 338 | -43 | $1,586 | $7,139,406 | 3 | Sony Pictures Releasing | false | false |
| 13 | 10 | Coco Before Chanel | $294,925 | -29.2% | 111 | +13 | $2,656 | $2,531,728 | 3 | Optimum Releasing | false | false |
| 14 | 9 | The Hangover | $241,219 | -48.3% | 168 | -71 | $1,435 | $35,753,716 | 3 | Warner Bros. | false | false |
| 15 | - | Kaminey | $185,140 | - | 28 | - | $6,612 | $185,140 | 1 | UTV Motion Pictures | true | false |
| 16 | - | Imagine That | $181,449 | - | 226 | - | $802 | $181,449 | 3 | Paramount Pictures International | false | false |
| 17 | 14 | Mesrine: Killer Instinct | $148,783 | -34.4% | 61 | +6 | $2,439 | $566,975 | 3 | Momentum Pictures | false | false |
| 18 | - | Life Partner | $148,042 | - | 32 | - | $4,626 | $148,042 | 1 | Studio 18 | true | false |
| 19 | - | Sin Nombre | $107,556 | - | 23 | - | $4,676 | $107,556 | 1 | Revolver Entertainment | true | false |
| 20 | 13 | Love Aaj Kal | $89,587 | -66.7% | 33 | -18 | $2,714 | $1,571,584 | 3 | Eros Worldwide | false | false |
| 21 | 11 | Brüno | $86,989 | -74.4% | 123 | -149 | $707 | $25,740,336 | 6 | Universal Pictures International (UPI) | false | false |
| 22 | 15 | Moon | $81,005 | -37% | 47 | -8 | $1,723 | $1,664,179 | 5 | Warner Bros. | false | false |
| 23 | 12 | Land of the Lost | $50,342 | -83.8% | 167 | -171 | $301 | $2,725,214 | 3 | Universal Pictures International (UPI) | false | false |
| 24 | 24 | Night at the Museum: Battle of the Smithsonian | $48,080 | +240.2% | 118 | +54 | $407 | $32,837,817 | 13 | 20th Century Fox International | false | false |
| 25 | - | Mid-August Lunch | $36,959 | - | 7 | - | $5,279 | $36,959 | 1 | Artificial Eye | true | false |
| 26 | 16 | Transformers: Revenge of the Fallen | $26,666 | -71.2% | 38 | -95 | $701 | $44,409,914 | 9 | Paramount Pictures International | false | false |
| 27 | 17 | My Sister's Keeper | $22,877 | -65.9% | 27 | -62 | $847 | $10,379,152 | 8 | Entertainment Film Distributors | false | false |
| 28 | 19 | Antichrist | $19,975 | -49.6% | 25 | -16 | $799 | $554,989 | 4 | Artificial Eye | false | false |
| 29 | 21 | Monsters vs. Aliens | $19,600 | -16.7% | 81 | -9 | $241 | $35,001,776 | 20 | Paramount Pictures International | false | false |
| 30 | 18 | Public Enemies | $18,318 | -67.2% | 23 | -33 | $796 | $11,332,398 | 7 | Universal Pictures International (UPI) | false | false |
| 31 | 28 | Hannah Montana: The Movie | $17,404 | +181.1% | 83 | +57 | $209 | $13,919,780 | 16 | Walt Disney Pictures | false | false |
| 32 | 20 | Adam | $11,801 | -69.5% | 17 | -9 | $694 | $93,162 | 2 | 20th Century Fox International | false | false |
| 33 | 27 | Frozen River | $6,876 | +2.4% | 8 | +1 | $859 | $146,932 | 5 | Axiom Films | false | false |
| 34 | 25 | Home | $5,846 | -51.7% | 7 | - | $835 | $28,378 | 2 | Soda Pictures | false | false |
| 35 | 26 | 35 Shots of Rum | $5,446 | -53.1% | 4 | -3 | $1,361 | $305,131 | 6 | New Wave Films | false | false |
| 36 | 31 | Looking for Eric | $4,543 | +6.9% | 6 | -1 | $757 | $2,138,196 | 10 | Entertainment Film Distributors | false | false |
| 37 | 29 | Sunshine Cleaning | $4,525 | -24% | 3 | -2 | $1,508 | $668,593 | 8 | N/A | false | false |
| 38 | 30 | Angels & Demons | $3,618 | -23.2% | 1 | - | $3,618 | $30,726,140 | 14 | Sony Pictures Releasing | false | false |
| 39 | 22 | Coraline | $3,347 | -80.5% | 18 | -66 | $185 | $12,196,560 | 15 | Universal Pictures International (UPI) | false | false |
| 40 | 33 | The Private Lives of Pippa Lee | $3,192 | -21.9% | 4 | -8 | $798 | $302,439 | 6 | Icon Film Distribution | false | false |
| 41 | 37 | Skin | $2,896 | -17.2% | 2 | - | $1,448 | $38,312 | 4 | ICA Films | false | false |
| 42 | 39 | Drag Me to Hell | $2,795 | -5.4% | 1 | - | $2,795 | $10,519,347 | 12 | Lionsgate | false | false |
| 43 | 23 | The Yes Men Fix the World | $2,244 | -85.9% | 2 | -15 | $1,122 | $20,571 | 2 | Periscoop Film | false | false |
| 44 | 42 | Crossing Over | $1,975 | -8% | 1 | -1 | $1,975 | $17,589 | 3 | Entertainment Film Distributors | false | false |
| 45 | 34 | Last Chance Harvey | $1,859 | -53.8% | 2 | -3 | $929 | $3,393,178 | 11 | Momentum Pictures | false | false |
| 46 | 46 | Katyn | $1,553 | +39.4% | 3 | +1 | $517 | $232,872 | 9 | Artificial Eye | false | false |
| 47 | 52 | The End of the Line | $1,455 | +185.3% | 3 | +1 | $485 | $90,015 | 10 | Periscoop Film | false | false |
| 48 | - | Telstar: The Joe Meek Story | $1,176 | - | 1 | - | $1,176 | $108,360 | 9 | N/A | false | false |
| 49 | 43 | Beautiful Losers | $1,128 | -38% | 1 | - | $1,128 | $5,034 | 2 | Revolver Entertainment | false | false |
| 50 | - | Synecdoche, New York | $857 | - | 2 | - | $428 | $875,852 | 14 | Revolver Entertainment | false | false |
| 51 | 44 | Rudo y Cursi | $809 | -48.6% | 1 | -3 | $809 | $269,133 | 8 | Optimum Releasing | false | false |
| 52 | 54 | In the Loop | $526 | +204% | 1 | - | $526 | $3,549,102 | 18 | Optimum Releasing | false | false |
| 53 | - | Cloud 9 | $486 | - | 2 | - | $243 | $28,302 | 6 | Soda Pictures | false | false |
| 54 | - | Am I Black Enough for You | $461 | - | 2 | - | $230 | $3,931 | 7 | Verve Pictures | false | false |
| 55 | 50 | Rumba | $327 | -44.9% | 1 | - | $327 | $5,527 | 3 | - | false | false |
| 56 | 48 | Kisses | $296 | -65.1% | 2 | -1 | $148 | $26,504 | 39 | Element Films | false | false |
| 57 | - | Shirin | $141 | - | 1 | - | $141 | $26,302 | 8 | British Film Institute (BFI) | false | false |
| 58 | - | Blue Eyelids 2009 Re-release | $124 | - | 1 | - | $124 | $48,093 | 15 | Axiom Films | false | false |
| 59 | - | Lake Tahoe | $124 | - | 1 | - | $124 | $16,628 | 8 | - | false | false |
| 60 | 38 | The Meerkats | $61 | -98.2% | 2 | -53 | $30 | $9,960 | 2 | Momentum Pictures | false | false |
| 61 | - | Fermat's Room 2009 Re-release | $33 | - | 1 | - | $33 | $48,369 | 12 | Revolver Entertainment | false | false |
| 62 | - | A Girl Cut in Two | $33 | - | 1 | - | $33 | $125,515 | 13 | Artificial Eye | false | false |
| 63 | 40 | Is Anybody There? | $33 | -98.7% | 1 | -1 | $33 | $769,537 | 16 | Optimum Releasing | false | false |
| 64 | - | Anything for Her | $33 | - | 1 | - | $33 | $453,878 | 11 | - | false | false |
| 65 | - | Il Divo | $33 | - | 1 | - | $33 | $587,414 | 22 | Artificial Eye | false | false |
| 66 | - | Everlasting Moments | $33 | - | 1 | - | $33 | $115,791 | 13 | Icon Film Distribution | false | false |
| 67 | 51 | The Young Victoria | $33 | -94% | 1 | - | $33 | $8,195,004 | 24 | Momentum Pictures | false | false |
| 68 | 53 | Shifty | $31 | -87.2% | 1 | - | $31 | $244,204 | 17 | - | false | false |
