| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Harry Potter and the Half-Blood Prince | $866,682 | -37% | 212 | -3 | $4,088 | $12,398,911 | 4 | Warner Bros. | false | false |
| 2 | 2 | Ice Age: Dawn of the Dinosaurs | $395,429 | -47.4% | 232 | -7 | $1,704 | $10,317,297 | 6 | 20th Century Fox International | false | false |
| 3 | 3 | Public Enemies | $363,539 | -41.8% | 80 | - | $4,544 | $1,243,487 | 2 | Universal Pictures International (UPI) | false | false |
| 4 | 4 | G-Force | $247,282 | -43.6% | 113 | +2 | $2,188 | $961,885 | 2 | Walt Disney Pictures | false | false |
| 5 | - | The Girl with the Dragon Tattoo | $160,424 | - | 30 | - | $5,347 | $183,029 | 1 | Benelux Film Distributors | true | false |
| 6 | - | A Perfect Getaway | $144,013 | - | 54 | - | $2,666 | $167,690 | 1 | A-Film Distribution | true | false |
| 7 | 8 | The Hangover | $128,621 | -16.5% | 65 | - | $1,978 | $4,252,274 | 9 | Warner Bros. | false | false |
| 8 | 5 | The Proposal | $127,236 | -28.2% | 81 | -1 | $1,570 | $3,490,499 | 8 | Walt Disney Pictures | false | false |
| 9 | 7 | Brüno | $85,506 | -49.8% | 84 | -8 | $1,017 | $2,764,890 | 5 | Universal Pictures International (UPI) | false | false |
| 10 | 10 | Ghosts of Girlfriends Past | $81,404 | -37.4% | 50 | - | $1,628 | $758,822 | 3 | RCV Film Distribution | false | false |
| 11 | 6 | Het geheim van Mega Mindy | $71,589 | -58.8% | 106 | - | $675 | $1,659,133 | 5 | Independent Films | false | false |
| 12 | 9 | Luke and Lucy: The Texas Rangers | $65,942 | -50% | 88 | - | $749 | $453,958 | 3 | RCV Film Distribution | false | false |
| 13 | 11 | Transformers: Revenge of the Fallen | $26,442 | -46.2% | 19 | -10 | $1,391 | $3,694,676 | 7 | Universal Pictures International (UPI) | false | false |
| 14 | 14 | Drag Me to Hell | $22,473 | -28.1% | 15 | +2 | $1,498 | $716,723 | 6 | RCV Film Distribution | false | false |
| 15 | 13 | Angels & Demons | $21,292 | -35.8% | 20 | -6 | $1,064 | $7,867,942 | 13 | Sony Pictures Releasing | false | false |
| 16 | 15 | The Private Lives of Pippa Lee | $16,641 | -34.2% | 12 | - | $1,386 | $58,273 | 2 | RCV Film Distribution | false | false |
| 17 | - | Red Cliff | $16,035 | - | 4 | - | $4,008 | $18,332 | 1 | Independent Films | true | false |
| 18 | 12 | Sunshine Barry and the Disco Worms | $15,246 | -61.4% | 55 | - | $277 | $68,060 | 2 | Independent Films | false | false |
| 19 | 16 | Coco Before Chanel | $12,020 | -50.3% | 22 | -3 | $546 | $966,553 | 11 | RCV Film Distribution | false | false |
| 20 | 17 | Welcome | $10,316 | -40.3% | 8 | - | $1,289 | $36,684 | 2 | Cinéart | false | false |
