| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Ugly Truth | $3,295,877 | - | 400 | - | $8,239 | $3,295,877 | 1 | Sony Pictures Releasing | true | false |
| 2 | - | G.I. Joe: The Rise of Cobra | $2,850,071 | - | 442 | - | $6,448 | $2,850,071 | 1 | Paramount Pictures International | true | false |
| 3 | 1 | Harry Potter and the Half-Blood Prince | $2,250,209 | -53.8% | 535 | -33 | $4,205 | $74,016,873 | 4 | Warner Bros. | false | false |
| 4 | 2 | G-Force | $2,041,349 | -50.7% | 426 | - | $4,791 | $10,460,062 | 2 | Walt Disney Pictures | false | false |
| 5 | - | The Proposal | $1,259,681 | - | 441 | - | $2,856 | $15,105,753 | 1 | Walt Disney Pictures | true | false |
| 6 | 3 | The Taking of Pelham 123 | $1,103,051 | -63% | 381 | +1 | $2,895 | $5,757,938 | 2 | Sony Pictures Releasing | false | false |
| 7 | 5 | Ice Age: Dawn of the Dinosaurs | $1,021,716 | -46.5% | 480 | -18 | $2,128 | $51,745,729 | 6 | 20th Century Fox International | false | false |
| 8 | - | Orphan | $950,957 | - | 285 | - | $3,336 | $950,957 | 1 | Optimum Releasing | true | false |
| 9 | 8 | The Hangover | $466,235 | -46.1% | 239 | -58 | $1,950 | $35,460,539 | 2 | Warner Bros. | false | false |
| 10 | 9 | Coco Before Chanel | $416,532 | -41.1% | 98 | +7 | $4,250 | $1,764,010 | 2 | Optimum Releasing | false | false |
| 11 | 7 | Brüno | $340,010 | -66.8% | 272 | -124 | $1,250 | $25,635,011 | 5 | Universal Pictures International (UPI) | false | false |
| 12 | 6 | Land of the Lost | $311,178 | -71% | 338 | -1 | $920 | $2,351,760 | 2 | Universal Pictures International (UPI) | false | false |
| 13 | 10 | Love Aaj Kal | $269,357 | -60.3% | 51 | -1 | $5,281 | $1,306,136 | 2 | Eros Worldwide | false | false |
| 14 | - | Mesrine: Killer Instinct | $226,835 | - | 55 | - | $4,124 | $226,835 | 2 | Momentum Pictures | false | false |
| 15 | 12 | Moon | $128,555 | -34.7% | 55 | -1 | $2,337 | $1,469,052 | 4 | Warner Bros. | false | false |
| 16 | 11 | Transformers: Revenge of the Fallen | $92,508 | -74.6% | 133 | -133 | $695 | $44,669,317 | 8 | Paramount Pictures International | false | false |
| 17 | 13 | My Sister's Keeper | $67,060 | -65.4% | 89 | -65 | $753 | $10,354,281 | 7 | Entertainment Film Distributors | false | false |
| 18 | 14 | Public Enemies | $55,882 | -69.2% | 56 | -76 | $997 | $11,360,212 | 6 | Universal Pictures International (UPI) | false | false |
| 19 | 15 | Antichrist | $39,601 | -51.3% | 41 | +6 | $965 | $501,586 | 3 | Artificial Eye | false | false |
| 20 | - | Adam | $38,697 | - | 26 | - | $1,488 | $38,697 | 1 | 20th Century Fox International | true | false |
| 21 | 30 | Monsters vs. Aliens | $23,531 | +337% | 90 | +69 | $261 | $35,279,535 | 19 | Paramount Pictures International | false | false |
| 22 | 17 | Coraline | $17,148 | -51.5% | 84 | -19 | $204 | $12,277,612 | 14 | Universal Pictures International (UPI) | false | false |
| 23 | - | The Yes Men Fix the World | $15,922 | - | 17 | - | $936 | $15,922 | 1 | Periscoop Film | true | false |
| 24 | 16 | Night at the Museum: Battle of the Smithsonian | $14,131 | -79.8% | 64 | -91 | $220 | $33,071,394 | 12 | 20th Century Fox International | false | false |
| 25 | - | Home | $12,096 | - | 7 | - | $1,728 | $12,096 | 1 | Soda Pictures | true | false |
| 26 | 18 | 35 Shots of Rum | $11,604 | -53.4% | 7 | -3 | $1,657 | $291,909 | 5 | New Wave Films | false | false |
| 27 | 21 | Frozen River | $6,718 | -42.7% | 7 | - | $959 | $129,537 | 4 | Axiom Films | false | false |
| 28 | 22 | Hannah Montana: The Movie | $6,191 | -32.8% | 26 | -7 | $238 | $14,019,109 | 15 | Walt Disney Pictures | false | false |
| 29 | 28 | Sunshine Cleaning | $5,953 | +0.2% | 5 | - | $1,190 | $663,746 | 7 | N/A | false | false |
| 30 | 26 | Angels & Demons | $4,710 | -27.9% | 1 | -1 | $4,710 | $30,980,937 | 13 | Sony Pictures Releasing | false | false |
| 31 | 24 | Looking for Eric | $4,250 | -42% | 7 | -4 | $607 | $2,133,930 | 9 | Entertainment Film Distributors | false | false |
| 32 | 19 | Luck | $4,098 | -79.8% | 6 | -17 | $683 | $273,447 | 3 | Studio 18 | false | false |
| 33 | 20 | The Private Lives of Pippa Lee | $4,085 | -65.3% | 12 | +4 | $340 | $294,478 | 5 | Icon Film Distribution | false | false |
| 34 | 32 | Last Chance Harvey | $4,025 | -24.2% | 5 | +1 | $805 | $3,415,782 | 10 | Momentum Pictures | false | false |
| 35 | 35 | Once Upon a Time in the West 2009 Re-release | $3,983 | -17% | 1 | - | $3,983 | $27,629 | 3 | British Film Institute (BFI) | false | false |
| 36 | 23 | Star Trek | $3,766 | -54.1% | 1 | -3 | $3,766 | $35,392,062 | 14 | Paramount Pictures International | false | false |
| 37 | 29 | Skin | $3,498 | -36% | 2 | - | $1,749 | $30,083 | 3 | ICA Films | false | false |
| 38 | - | The Meerkats | $3,423 | - | 55 | - | $62 | $3,423 | 1 | Momentum Pictures | true | false |
| 39 | 34 | Drag Me to Hell | $2,956 | -41% | 1 | -1 | $2,956 | $10,603,539 | 11 | Lionsgate | false | false |
| 40 | - | Is Anybody There? | $2,464 | - | 2 | - | $1,232 | $775,650 | 15 | Optimum Releasing | false | false |
| 41 | 27 | Terminator Salvation | $2,225 | -62.8% | 3 | -1 | $741 | $23,688,598 | 10 | Sony Pictures Releasing | false | false |
| 42 | 31 | Crossing Over | $2,147 | -60% | 2 | -2 | $1,073 | $13,192 | 2 | Entertainment Film Distributors | false | false |
| 43 | - | Beautiful Losers | $1,820 | - | 1 | - | $1,820 | $1,820 | 1 | Revolver Entertainment | true | false |
| 44 | 33 | Rudo y Cursi | $1,573 | -69.6% | 4 | -1 | $393 | $268,346 | 7 | Optimum Releasing | false | false |
| 45 | - | North by Northwest 2009 Re-release | $1,269 | - | 1 | - | $1,269 | $48,611 | 8 | British Film Institute (BFI) | false | false |
| 46 | 25 | Katyn | $1,114 | -83.4% | 2 | -5 | $557 | $230,915 | 8 | Artificial Eye | false | false |
| 47 | 42 | Mad Sad & Bad | $907 | -53% | 3 | +1 | $302 | $4,507 | 2 | Soda Pictures | false | false |
| 48 | 44 | Kisses | $849 | -41.2% | 3 | -1 | $283 | $24,785 | 38 | Element Films | false | false |
| 49 | - | Mega Shark vs. Giant Octopus | $722 | - | 1 | - | $722 | $722 | 1 | - | true | false |
| 50 | 41 | Rumba | $594 | -69.3% | 1 | -1 | $594 | $4,563 | 2 | - | false | false |
| 51 | - | The Young Victoria | $552 | - | 1 | - | $552 | $8,265,000 | 23 | Momentum Pictures | false | false |
| 52 | 51 | The End of the Line | $510 | +191.4% | 2 | +1 | $255 | $89,320 | 9 | Periscoop Film | false | false |
| 53 | - | Shifty | $242 | - | 1 | - | $242 | $245,362 | 16 | - | false | false |
| 54 | - | In the Loop | $173 | - | 1 | - | $173 | $3,577,393 | 17 | Optimum Releasing | false | false |
