| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Ugly Truth | $2,764,376 | - | 283 | - | $9,768 | $2,817,453 | 1 | Sony Pictures Releasing | true | false |
| 2 | - | G.I. Joe: The Rise of Cobra | $2,343,940 | - | 223 | - | $10,510 | $2,343,940 | 1 | Paramount Pictures International | true | false |
| 3 | 2 | Harry Potter and the Half-Blood Prince | $1,342,741 | -46.9% | 377 | -107 | $3,561 | $30,566,902 | 4 | Warner Bros. | false | false |
| 4 | 1 | Public Enemies | $1,338,573 | -49.1% | 283 | -1 | $4,729 | $4,886,172 | 2 | Universal Pictures International (UPI) | false | false |
| 5 | 3 | My Sister's Keeper | $1,244,011 | -33.8% | 210 | - | $5,923 | $3,911,604 | 2 | Roadshow Films | false | false |
| 6 | 10 | Coraline | $923,624 | +264.4% | 212 | +26 | $4,356 | $1,177,349 | 2 | Trafalgar Releasing | false | false |
| 7 | 4 | Ice Age: Dawn of the Dinosaurs | $282,553 | -54.1% | 235 | -71 | $1,202 | $24,442,590 | 6 | 20th Century Fox International | false | false |
| 8 | 5 | The Hangover | $247,977 | -49.4% | 141 | -39 | $1,758 | $17,424,623 | 9 | Warner Bros. | false | false |
| 9 | 18 | Beautiful Kate | $228,918 | +463% | 29 | - | $7,893 | $289,383 | 2 | Roadshow Films | false | false |
| 10 | 6 | Drag Me to Hell | $192,599 | -59.2% | 131 | -8 | $1,470 | $2,045,438 | 3 | Roadshow Films | false | false |
| 11 | 7 | Transformers: Revenge of the Fallen | $181,549 | -60.4% | 135 | -99 | $1,344 | $33,399,627 | 7 | Paramount Pictures International | false | false |
| 12 | 9 | The Proposal | $102,039 | -60.3% | 90 | -40 | $1,133 | $13,776,361 | 8 | Walt Disney Pictures | false | false |
| 13 | 8 | Brüno | $92,938 | -72.2% | 96 | -135 | $968 | $11,651,106 | 5 | Universal Pictures International (UPI) | false | false |
| 14 | 13 | Chéri | $86,341 | -40.2% | 55 | +1 | $1,569 | $669,158 | 3 | Icon Film Distribution | false | false |
| 15 | 11 | My Life in Ruins | $80,904 | -65.4% | 96 | -68 | $842 | $2,121,213 | 4 | 20th Century Fox International | false | false |
| 16 | 14 | Coco Before Chanel | $80,353 | -29.5% | 39 | +1 | $2,060 | $1,907,414 | 7 | Roadshow Films | false | false |
| 17 | 12 | Love Aaj Kal | $60,639 | -64.7% | 16 | - | $3,789 | $291,114 | 2 | Eros Worldwide | false | false |
| 18 | 15 | Red Cliff | $45,449 | -59.1% | 49 | -8 | $927 | $545,179 | 3 | Icon Film Distribution | false | false |
| 19 | 16 | Hannah Montana: The Movie | $37,481 | -66.2% | 62 | -70 | $604 | $8,715,937 | 7 | Walt Disney Pictures | false | false |
| 20 | 17 | Cedar Boys | $29,935 | -52.1% | 32 | -1 | $935 | $138,763 | 2 | Hoyts Distribution | false | false |
| 21 | - | Balibo | $28,525 | - | 14 | - | $2,037 | $28,525 | - | Paramount Pictures International | - | false |
| 22 | - | Tyson | $28,436 | - | 7 | - | $4,062 | $30,142 | 1 | Hopscotch Films | true | false |
| 23 | - | Bronson | $2,454 | - | 1 | - | $2,454 | $2,454 | 1 | Madman Entertainment | true | false |
