| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Harry Potter and the Half-Blood Prince | $286,464 | -42.5% | 93 | - | $3,080 | $3,311,601 | 3 | Warner Bros. | false | false |
| 2 | - | Public Enemies | $252,784 | - | 48 | - | $5,266 | $259,067 | 1 | United International Pictures | true | false |
| 3 | 2 | Ice Age: Dawn of the Dinosaurs | $93,592 | -27.3% | 75 | +3 | $1,247 | $3,423,942 | 5 | 20th Century Fox International | false | false |
| 4 | 3 | Transformers: Revenge of the Fallen | $80,345 | -37.5% | 72 | -13 | $1,115 | $5,112,283 | 6 | Paramount Pictures International | false | false |
| 5 | 4 | Brüno | $76,663 | -39.3% | 50 | - | $1,533 | $1,435,057 | 4 | United International Pictures | false | false |
| 6 | 6 | The Hangover | $63,397 | -7.6% | 43 | +6 | $1,474 | $1,897,217 | 8 | Warner Bros. | false | false |
| 7 | 5 | Drag Me to Hell | $56,318 | -37% | 34 | - | $1,656 | $186,903 | 2 | Roadshow Films | false | false |
| 8 | 7 | The Proposal | $39,270 | -32.1% | 39 | -1 | $1,006 | $1,494,995 | 7 | Walt Disney Pictures | false | false |
| 9 | 9 | My Life in Ruins | $38,762 | -5.9% | 25 | - | $1,550 | $179,416 | 3 | 20th Century Fox International | false | false |
| 10 | - | Love Aaj Kal | $32,061 | - | 6 | - | $5,343 | $32,061 | 1 | - | true | false |
| 11 | 8 | Hannah Montana: The Movie | $30,629 | -31.2% | 65 | -3 | $471 | $1,233,332 | 6 | Walt Disney Pictures | false | false |
| 12 | 10 | Stone of Destiny | $20,437 | -36% | 26 | -1 | $786 | $66,753 | 2 | Rialto Distribution | false | false |
| 13 | - | Coco Before Chanel | $13,503 | - | 3 | - | $4,501 | $13,503 | - | Warner Bros. | - | false |
| 14 | 15 | I've Loved You So Long | $8,683 | +5.6% | 11 | +2 | $789 | $310,126 | 12 | Palace Films | false | false |
| 15 | 11 | The Sicilian Girl | $7,795 | -28.7% | 11 | -1 | $708 | $62,227 | 4 | Vendetta Films | false | false |
| 16 | 14 | Bride Flight | $7,782 | -14.3% | 21 | -6 | $370 | $136,541 | 6 | Hopscotch Films | false | false |
| 17 | 12 | Easy Virtue | $7,692 | -18.7% | 21 | -5 | $366 | $587,223 | 10 | Hopscotch Films | false | false |
| 18 | - | Faintheart | $5,090 | - | 8 | - | $636 | $5,090 | 1 | Rialto Distribution | true | false |
| 19 | 17 | The Reader | $4,458 | -17% | 16 | - | $278 | $866,562 | 17 | Roadshow Films | false | false |
| 20 | 16 | A Bunch of Amateurs | $3,327 | -48.6% | 7 | -11 | $475 | $173,799 | 116 | Rialto Distribution | false | false |
| 21 | 20 | Angels & Demons | $1,840 | -33.3% | 6 | -3 | $306 | $1,875,626 | 12 | Sony Pictures Releasing | false | false |
| 22 | 19 | Terminator Salvation | $1,433 | -52.4% | 4 | -2 | $358 | $1,647,499 | 9 | Sony Pictures Releasing | false | false |
| 23 | - | The Class | $485 | - | 2 | - | $242 | $66,219 | 15 | Sony Pictures Releasing | false | false |
