| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Terminator Salvation | $2,662,787 | - | 771 | - | $3,453 | $2,898,260 | 1 | Sony Pictures Releasing | true | false |
| 2 | - | G-Force | $2,614,557 | - | 696 | - | $3,756 | $2,877,026 | 1 | Walt Disney Pictures | true | false |
| 3 | 1 | Harry Potter and the Half-Blood Prince | $1,243,506 | -53.1% | 498 | -511 | $2,497 | $19,738,373 | 3 | Warner Bros. | false | false |
| 4 | 2 | Ice Age: Dawn of the Dinosaurs | $1,113,784 | -47.7% | 473 | +6 | $2,354 | $38,154,758 | 5 | 20th Century Fox International | false | false |
| 5 | 3 | The Uninvited | $322,587 | -29.6% | 242 | -7 | $1,333 | $1,235,038 | 2 | Paramount Pictures International | false | false |
| 6 | 8 | My Sister's Keeper | $228,263 | +16.3% | 145 | +14 | $1,574 | $2,534,302 | 6 | Warner Bros. | false | false |
| 7 | 6 | Crossing Over | $169,220 | -38.5% | 167 | -25 | $1,013 | $672,603 | 2 | N/A | false | false |
| 8 | 5 | Public Enemies | $137,400 | -56.3% | 157 | -117 | $875 | $5,095,455 | 5 | Universal Pictures International (UPI) | false | false |
| 9 | 4 | Transformers: Revenge of the Fallen | $126,711 | -63% | 217 | -158 | $583 | $18,768,524 | 6 | Paramount Pictures International | false | false |
| 10 | 12 | The Code | $69,083 | -19.6% | 72 | -17 | $959 | $868,629 | 4 | Gussi Films | false | false |
| 11 | 10 | The Proposal | $51,407 | -56.5% | 52 | -48 | $988 | $6,567,257 | 7 | Walt Disney Pictures | false | false |
| 12 | 14 | Smother | $49,284 | +117.2% | 61 | +38 | $807 | $263,868 | 4 | Videocine | false | false |
| 13 | 9 | All Inclusive | $45,327 | -62% | 58 | -80 | $781 | $1,378,675 | 4 | Universal Pictures International (UPI) | false | false |
| 14 | 11 | How to Lose Friends & Alienate People | $37,486 | -59% | 66 | -33 | $567 | $221,067 | 2 | N/A | false | false |
| 15 | 13 | 17 Again | $27,546 | -55.7% | 45 | -30 | $612 | $2,564,912 | 7 | Gussi Films | false | false |
| 16 | 22 | Happy-Go-Lucky | $13,893 | +75.2% | 10 | +1 | $1,389 | $125,533 | 6 | N/A | false | false |
| 17 | 15 | Reprise | $11,704 | -32.1% | 9 | -3 | $1,300 | $44,051 | 2 | N/A | false | false |
| 18 | 16 | Up | $5,060 | -62.3% | 19 | -15 | $266 | $14,192,640 | 9 | Walt Disney Pictures | false | false |
| 19 | 21 | Gomorrah | $4,448 | -49.2% | 8 | - | $556 | $81,827 | 4 | N/A | false | false |
| 20 | 24 | Three Monkeys | $3,763 | -11.6% | 4 | - | $940 | $50,967 | 8 | N/A | false | false |
| 21 | 25 | I'm Gonna Explode | $2,914 | +31.7% | 20 | +3 | $145 | $62,360 | 116 | Videocine | false | false |
| 22 | 23 | Waltz with Bashir | $2,765 | -63.7% | 4 | -6 | $691 | $39,883 | 3 | N/A | false | false |
| 23 | 30 | Rachel Getting Married | $1,826 | +155% | 5 | +3 | $365 | $158,600 | 20 | Sony Pictures Releasing | false | false |
| 24 | 26 | Blame it on Fidel | $1,622 | -20.2% | 5 | - | $324 | $43,938 | 6 | N/A | false | false |
| 25 | 18 | Night at the Museum: Battle of the Smithsonian | $1,469 | -84.4% | 11 | -16 | $133 | $10,088,016 | 8 | 20th Century Fox International | false | false |
| 26 | 29 | Religulous | $1,139 | -13.8% | 3 | +1 | $379 | $32,283 | 4 | N/A | false | false |
| 27 | 19 | It's Alive | $620 | -93.4% | 2 | -32 | $310 | $138,068 | 3 | Gussi Films | false | false |
