| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Harry Potter and the Half-Blood Prince | $1,114,446 | -50.5% | 813 | -57 | $1,370 | $22,760,410 | 3 | Warner Bros. | false | false |
| 2 | 3 | The Hangover | $192,067 | +3.7% | 142 | -1 | $1,352 | $4,551,523 | 7 | Warner Bros. | false | false |
| 3 | 4 | Ghosts of Girlfriends Past | $154,779 | -9.7% | 148 | -23 | $1,045 | $2,148,471 | 5 | Warner Bros. | false | false |
| 4 | 2 | Transformers: Revenge of the Fallen | $150,244 | -19.7% | 172 | -33 | $873 | $11,143,030 | 6 | United International Pictures | false | false |
| 5 | 6 | Coraline | $71,678 | -13.9% | 74 | -26 | $968 | $4,641,133 | 7 | United International Pictures | false | false |
| 6 | 5 | Outlander | $70,787 | -20.2% | 101 | -14 | $700 | $1,433,959 | 5 | Eagle Pictures | false | false |
| 7 | 11 | The Boat That Rocked | $38,120 | +15.4% | 41 | +4 | $929 | $954,655 | 8 | United International Pictures | false | false |
| 8 | 9 | The Girl with the Dragon Tattoo | $34,567 | -7.1% | 41 | +4 | $843 | $5,048,540 | 10 | BIM Distribuzione | false | false |
| 9 | 10 | Un'estate ai Caraibi | $30,634 | -16.7% | 57 | - | $537 | $5,156,631 | 8 | Medusa Distribuzione | false | false |
| 10 | 29 | Journey to the Center of the Earth | $29,907 | +543.2% | 25 | +20 | $1,196 | $11,503,190 | 29 | 01 Distribution | false | false |
| 11 | - | Imagine That | $23,132 | - | 12 | - | $1,927 | $23,132 | 1 | United International Pictures | true | false |
| 12 | 7 | Soul Men | $20,858 | -54.9% | 6 | -3 | $3,476 | $219,923 | 3 | 01 Distribution | false | false |
| 13 | - | Killshot | $20,188 | - | 12 | - | $1,682 | $20,188 | 1 | 01 Distribution | true | false |
| 14 | 13 | Angels & Demons | $20,105 | +2.9% | 14 | -1 | $1,436 | $26,101,009 | 12 | Sony Pictures Releasing | false | false |
| 15 | 8 | Baby Mama | $17,526 | -61% | 64 | -38 | $273 | $91,906 | 2 | United International Pictures | false | false |
| 16 | - | Ultimate Heist | $16,510 | - | 3 | - | $5,503 | $16,510 | 1 | Medusa Distribuzione | true | false |
| 17 | 12 | Notorious | $15,839 | -50.8% | 41 | -41 | $386 | $183,001 | 3 | 20th Century Fox International | false | false |
| 18 | 18 | Gran Torino | $14,735 | +31.4% | 28 | +9 | $526 | $12,981,863 | 21 | Warner Bros. | false | false |
| 19 | 14 | Towelhead | $13,428 | -23.1% | 20 | - | $671 | $70,295 | 3 | N/A | false | false |
| 20 | 23 | Slumdog Millionaire | $10,915 | +59.6% | 19 | +5 | $574 | $8,849,262 | 35 | Lucky Red | false | false |
| 21 | 24 | State of Play | $10,893 | +79.7% | 8 | +3 | $1,361 | $3,520,768 | 14 | United International Pictures | false | false |
| 22 | 21 | Vincere | $10,890 | +25.2% | 17 | +5 | $640 | $2,957,650 | 11 | 01 Distribution | false | false |
| 23 | 22 | Night at the Museum: Battle of the Smithsonian | $10,786 | +37.5% | 18 | +3 | $599 | $9,934,101 | 11 | 20th Century Fox International | false | false |
| 24 | 15 | My Best Friend's Girl | $10,717 | -26.1% | 20 | -9 | $535 | $1,506,434 | 7 | Eagle Pictures | false | false |
| 25 | - | 12 Rounds | $10,037 | - | 10 | - | $1,003 | $10,037 | 5 | 20th Century Fox International | false | false |
| 26 | - | We Can Do That | $9,305 | - | 9 | - | $1,033 | $2,759,692 | 40 | Warner Bros. | false | false |
| 27 | - | Coco Before Chanel | $9,005 | - | 17 | - | $529 | $1,765,122 | 10 | Warner Bros. | false | false |
| 28 | 16 | Obsessed | $8,852 | -29.2% | 8 | -4 | $1,106 | $57,615 | 3 | Sony Pictures Releasing | false | false |
| 29 | 17 | Ghost Town | $8,192 | -34.3% | 19 | -5 | $431 | $84,597 | 3 | United International Pictures | false | false |
| 30 | - | The Visitor | $7,176 | - | 7 | - | $1,025 | $2,185,026 | 35 | Bolero Film | false | false |
| 31 | - | Mamma Mia! | $6,821 | - | 9 | - | $757 | $12,919,298 | 44 | United International Pictures | false | false |
| 32 | 28 | The Friends at the Margherita Cafe | $6,059 | +28.6% | 17 | +10 | $356 | $4,300,957 | 18 | 01 Distribution | false | false |
| 33 | 27 | Adventureland | $5,853 | +14.3% | 7 | +1 | $836 | $21,759 | 4 | Walt Disney Pictures | false | false |
| 34 | 31 | Louise hires a contract killer | $5,716 | +29.1% | 4 | - | $1,429 | $803,171 | 18 | Fandango | false | false |
| 35 | 25 | Monsters vs. Aliens | $5,507 | +3.7% | 8 | -1 | $688 | $10,515,090 | 18 | United International Pictures | false | false |
