| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Harry Potter and the Half-Blood Prince | $4,875,246 | -42.7% | 568 | -18 | $8,583 | $67,733,092 | 3 | Warner Bros. | false | false |
| 2 | - | G-Force | $4,141,296 | - | 426 | - | $9,721 | $4,141,296 | 1 | Walt Disney Pictures | true | false |
| 3 | - | The Taking of Pelham 123 | $2,982,036 | - | 380 | - | $7,847 | $2,982,036 | 1 | Sony Pictures Releasing | true | false |
| 4 | - | The Proposal | $2,488,376 | - | 430 | - | $5,786 | $11,506,874 | - | Walt Disney Pictures | - | false |
| 5 | 3 | Ice Age: Dawn of the Dinosaurs | $1,910,159 | -45.9% | 498 | -9 | $3,835 | $48,713,828 | 5 | 20th Century Fox International | false | false |
| 6 | - | Land of the Lost | $1,073,624 | - | 339 | - | $3,167 | $1,073,624 | 1 | Universal Pictures International (UPI) | true | false |
| 7 | 4 | Brüno | $1,023,538 | -48.6% | 396 | -49 | $2,584 | $24,611,466 | 4 | Universal Pictures International (UPI) | false | false |
| 8 | - | The Hangover | $865,336 | - | 297 | - | $2,913 | $34,425,787 | 1 | Warner Bros. | true | false |
| 9 | - | Coco Before Chanel | $707,227 | - | 91 | - | $7,771 | $707,227 | 1 | Optimum Releasing | true | false |
| 10 | - | Love Aaj Kal | $677,828 | - | 52 | - | $13,035 | $677,828 | 1 | Eros Worldwide | true | false |
| 11 | 6 | Transformers: Revenge of the Fallen | $364,593 | -46.7% | 266 | -94 | $1,370 | $44,344,731 | 7 | Paramount Pictures International | false | false |
| 12 | 9 | Moon | $196,914 | -13.1% | 56 | -3 | $3,516 | $1,170,269 | 3 | Warner Bros. | false | false |
| 13 | 8 | My Sister's Keeper | $193,804 | -47.4% | 154 | -129 | $1,258 | $10,097,679 | 6 | Entertainment Film Distributors | false | false |
| 14 | 7 | Public Enemies | $181,358 | -60.2% | 132 | -145 | $1,373 | $11,173,035 | 5 | Universal Pictures International (UPI) | false | false |
| 15 | 10 | Antichrist | $81,371 | -50% | 35 | -3 | $2,324 | $394,197 | 2 | Artificial Eye | false | false |
| 16 | 12 | Night at the Museum: Battle of the Smithsonian | $70,011 | +19.1% | 155 | +17 | $451 | $33,038,754 | 11 | 20th Century Fox International | false | false |
| 17 | 35 | Coraline | $35,347 | +595.7% | 103 | +78 | $343 | $12,242,702 | 13 | Universal Pictures International (UPI) | false | false |
| 18 | 14 | 35 Shots of Rum | $24,918 | -25.2% | 10 | -9 | $2,491 | $263,025 | 4 | New Wave Films | false | false |
| 19 | 11 | Luck | $20,316 | -85.7% | 23 | -12 | $883 | $256,424 | 2 | Studio 18 | false | false |
| 20 | 16 | The Private Lives of Pippa Lee | $11,778 | -51.7% | 8 | -11 | $1,472 | $278,753 | 4 | Icon Film Distribution | false | false |
| 21 | 18 | Frozen River | $11,730 | -51% | 7 | -1 | $1,675 | $113,253 | 3 | Axiom Films | false | false |
| 22 | 19 | Hannah Montana: The Movie | $9,218 | -34.1% | 33 | -9 | $279 | $14,028,360 | 14 | Walt Disney Pictures | false | false |
| 23 | 22 | Star Trek | $8,202 | -36.5% | 4 | -8 | $2,050 | $35,442,021 | 13 | Paramount Pictures International | false | false |
| 24 | 21 | Looking for Eric | $7,332 | -43.4% | 11 | -3 | $666 | $2,102,047 | 8 | Entertainment Film Distributors | false | false |
| 25 | 30 | Katyn | $6,724 | +3.7% | 7 | +1 | $960 | $225,217 | 7 | Artificial Eye | false | false |
| 26 | 26 | Angels & Demons | $6,536 | -15.1% | 2 | -3 | $3,268 | $31,021,917 | 12 | Sony Pictures Releasing | false | false |
| 27 | 20 | Terminator Salvation | $5,988 | -56% | 4 | -18 | $1,497 | $23,719,222 | 9 | Sony Pictures Releasing | false | false |
| 28 | 24 | Sunshine Cleaning | $5,943 | -33.2% | 5 | -2 | $1,188 | $653,399 | 6 | N/A | false | false |
| 29 | 27 | Skin | $5,462 | -22.1% | 2 | - | $2,731 | $21,364 | 2 | ICA Films | false | false |
| 30 | 33 | Monsters vs. Aliens | $5,385 | +4.6% | 21 | -7 | $256 | $35,313,382 | 18 | Paramount Pictures International | false | false |
| 31 | - | Crossing Over | $5,370 | - | 4 | - | $1,342 | $5,370 | 1 | Entertainment Film Distributors | true | false |
| 32 | 36 | Last Chance Harvey | $5,307 | +6.5% | 4 | +1 | $1,326 | $3,398,744 | 9 | Momentum Pictures | false | false |
| 33 | 31 | Rudo y Cursi | $5,178 | -9.3% | 5 | -1 | $1,035 | $262,556 | 6 | Optimum Releasing | false | false |
| 34 | 32 | Drag Me to Hell | $5,011 | -4.2% | 2 | -1 | $2,505 | $10,615,325 | 10 | Lionsgate | false | false |
| 35 | 28 | Once Upon a Time in the West 2009 Re-release | $4,800 | -30.7% | 1 | -1 | $4,800 | $19,180 | 2 | British Film Institute (BFI) | false | false |
| 36 | 15 | Kambakkht Ishq | $4,774 | -85% | 3 | -20 | $1,591 | $1,170,803 | 5 | Eros Worldwide | false | false |
| 37 | 17 | Year One | $4,306 | -82.3% | 12 | -56 | $358 | $4,781,390 | 7 | Sony Pictures Releasing | false | false |
| 38 | 42 | Cloud 9 | $2,774 | +14.8% | 2 | -1 | $1,387 | $24,964 | 4 | Soda Pictures | false | false |
| 39 | 44 | Burma VJ: Reporting from a Closed Country | $2,495 | +29.7% | 3 | - | $831 | $68,977 | 3 | Periscoop Film | false | false |
| 40 | 34 | Just Another Love Story | $2,304 | -55% | 4 | - | $576 | $12,687 | 2 | Revolver Entertainment | false | false |
| 41 | - | Rumba | $1,935 | - | 2 | - | $967 | $1,935 | 1 | - | true | false |
| 42 | - | Mad Sad & Bad | $1,928 | - | 2 | - | $964 | $1,928 | 1 | Soda Pictures | true | false |
| 43 | - | A Girl Cut in Two | $1,529 | - | 1 | - | $1,529 | $125,529 | 11 | Artificial Eye | false | false |
| 44 | 41 | Kisses | $1,444 | -54.2% | 4 | -2 | $361 | $22,291 | 37 | Element Films | false | false |
| 45 | 47 | Synecdoche, New York | $1,347 | -14.2% | 1 | - | $1,347 | $882,494 | 12 | Revolver Entertainment | false | false |
| 46 | - | Let the Right One In | $1,069 | - | 1 | - | $1,069 | $1,830,884 | 17 | Momentum Pictures | false | false |
| 47 | 25 | New York | $979 | -87.3% | 2 | -5 | $489 | $666,935 | 6 | Yash Raj Films | false | false |
| 48 | - | The 400 Blows 2009 Re-release | $874 | - | 1 | - | $874 | $117,270 | 17 | British Film Institute (BFI) | false | false |
| 49 | 46 | Telstar: The Joe Meek Story | $867 | -50.3% | 2 | -1 | $433 | $108,024 | 7 | N/A | false | false |
| 50 | 52 | Shadows in the Sun | $358 | -26.8% | 1 | - | $358 | $16,652 | 9 | Artificial Eye | false | false |
| 51 | 54 | The End of the Line | $175 | +430.3% | 1 | - | $175 | $88,469 | 8 | Periscoop Film | false | false |
