| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Up | $5,277,056 | -40.6% | 718 | - | $7,349 | $16,537,304 | 2 | Walt Disney Pictures | false | false |
| 2 | - | G.I. Joe: The Rise of Cobra | $3,249,592 | - | 514 | - | $6,322 | $3,249,592 | - | Paramount Pictures International | - | false |
| 3 | 2 | Harry Potter and the Half-Blood Prince | $2,892,311 | -41% | 918 | -31 | $3,150 | $45,254,655 | 4 | Warner Bros. | false | false |
| 4 | 3 | Ice Age: Dawn of the Dinosaurs | $2,166,083 | -26% | 750 | -33 | $2,888 | $59,761,242 | 6 | 20th Century Fox International | false | false |
| 5 | 4 | The Taking of Pelham 123 | $1,263,183 | -47% | 396 | +3 | $3,189 | $4,202,749 | 3 | Sony Pictures Releasing | false | false |
| 6 | 7 | The Hangover | $736,987 | -9.2% | 240 | +7 | $3,070 | $13,301,273 | 7 | Warner Bros. | false | false |
| 7 | 5 | Public Enemies | $644,387 | -32.4% | 383 | -55 | $1,682 | $11,746,782 | 7 | Universal Pictures International (UPI) | false | false |
| 8 | 6 | Alternate Weeks (and Half the Vacation) | $550,369 | -35.9% | 331 | -9 | $1,662 | $3,381,923 | 3 | TFM Distribution | false | false |
| 9 | - | Queen to Play | $521,379 | - | 170 | - | $3,066 | $521,379 | - | StudioCanal | - | false |
| 10 | 8 | The Reader | $487,918 | -30.4% | 273 | -12 | $1,787 | $4,680,365 | 4 | TFM Distribution | false | false |
| 11 | - | Little New York | $385,483 | - | 170 | - | $2,267 | $385,483 | 1 | EuropaCorp | true | false |
| 12 | 11 | Whatever Works | $255,071 | -30.1% | 222 | -30 | $1,148 | $6,260,093 | 6 | Mars Distribution | false | false |
| 13 | 13 | The Hedgehog | $230,701 | -24% | 231 | -25 | $998 | $5,668,403 | 6 | Pathé | false | false |
| 14 | 9 | Ong Bak 2 | $159,281 | -63.4% | 165 | -86 | $965 | $2,079,995 | 3 | EuropaCorp | false | false |
| 15 | 12 | Every Jack Has a Jill | $148,133 | -54.7% | 82 | - | $1,806 | $570,693 | 2 | Mars Distribution | false | false |
| 16 | - | The Brothers Bloom | $145,460 | - | 55 | - | $2,644 | $145,460 | 1 | SND Films | true | false |
| 17 | 10 | Brüno | $145,365 | -63.3% | 77 | -137 | $1,887 | $1,811,379 | 3 | Sony Pictures Releasing | false | false |
| 18 | 14 | Transformers: Revenge of the Fallen | $141,524 | -51% | 118 | -80 | $1,199 | $19,478,323 | 7 | Paramount Pictures International | false | false |
| 19 | 16 | Goodbye Gary Cooper | $95,679 | -41.3% | 65 | -2 | $1,471 | $603,488 | 3 | StudioCanal | false | false |
| 20 | - | Silk | $89,720 | - | 37 | - | $2,424 | $89,720 | 1 | Metropolitan Filmexport | true | false |
| 21 | 15 | Totally Spies! The Movie | $89,106 | -54.7% | 202 | -70 | $441 | $1,108,184 | 3 | Mars Distribution | false | false |
| 22 | 19 | Park Benches | $79,056 | -23.3% | 98 | -11 | $806 | $1,776,361 | 5 | UGC Distribution | false | false |
| 23 | 18 | The Midnight Meat Train | $68,627 | -51.2% | 55 | -3 | $1,247 | $251,076 | 4 | Metropolitan Filmexport | false | false |
| 24 | 17 | The Young Victoria | $52,765 | -67% | 61 | -69 | $865 | $798,669 | 3 | Metropolitan Filmexport | false | false |
| 25 | 24 | The Boat That Rocked | $46,348 | -4.9% | 51 | -11 | $908 | $7,060,076 | 14 | StudioCanal | false | false |
| 26 | - | L'amour | $42,101 | - | 22 | - | $1,913 | $42,101 | 1 | N/A | true | false |
| 27 | - | Zion and His Brother | $39,083 | - | 15 | - | $2,605 | $39,083 | 5 | MK2 Diffusion | false | false |
| 28 | - | Marching Band | $38,106 | - | 34 | - | $1,120 | $38,106 | 8 | Les Films du Losange | false | false |
| 29 | 20 | Simon Konianski | $33,721 | -55.7% | 37 | -6 | $911 | $131,579 | 2 | N/A | false | false |
| 30 | 23 | Somers Town | $26,353 | -48.2% | 25 | +1 | $1,054 | $91,736 | 6 | Ad Vitam Distribution | false | false |
| 31 | 22 | State of Play | $25,452 | -54% | 51 | -9 | $499 | $5,924,105 | 6 | StudioCanal | false | false |
| 32 | - | Looking for Eric | $12,099 | - | 26 | - | $465 | $4,286,398 | 11 | Diaphana Distribution | false | false |
| 33 | - | Divorce Italian Style | $11,079 | - | 8 | - | $1,384 | $131,467 | 5 | Ad Vitam Distribution | false | false |
| 34 | - | Knitting | $10,144 | - | 3 | - | $3,381 | $10,144 | 1 | N/A | true | false |
| 35 | - | Liverpool | $9,167 | - | 3 | - | $3,055 | $9,167 | 1 | N/A | true | false |
